Mechanical Unloading in Heart Failure

Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means...

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Veröffentlicht in:Journal of the American College of Cardiology Jg. 72; H. 5; S. 569
Hauptverfasser: Uriel, Nir, Sayer, Gabriel, Annamalai, Shiva, Kapur, Navin K, Burkhoff, Daniel
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 31.07.2018
Schlagworte:
Heart Failure - diagnosis
Heart Failure - physiopathology
Heart Failure - therapy
Hemodynamics - physiology
Humans
Myocardial Infarction - diagnosis
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Ventricular Function, Left - physiology
Ventricular Remodeling - physiology
mechanical circulatory support
remodeling
LVAD
acute myocardial infarction
hemodynamics
ISSN:1558-3597, 1558-3597
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Zusammenfassung:Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or reversing cardiac remodeling. In acute myocardial infarction, cardiac unloading is used to reduce oxygen demand and limit infarct size. Research has demonstrated the benefits of short-term unloading with mechanical circulatory support devices before reperfusion in the context of acute myocardial infarction with cardiogenic shock, and a confirmatory trial is ongoing. In chronic heart failure, ventricular unloading using mechanical circulatory support can reverse many of the cellular and anatomic changes that accompany ventricular remodeling. Ongoing research is evaluating the ability of left ventricular assist devices to promote myocardial recovery and remission from clinical heart failure.
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ISSN:1558-3597
1558-3597
DOI:10.1016/j.jacc.2018.05.038