Delayed Diagnosis of Hidradenitis Suppurativa and Its Effect on Patients and Healthcare System
Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders. Objectives: To determine the del...
Uložené v:
| Vydané v: | Dermatology (Basel) Ročník 236; číslo 5; s. 421 - 430 |
|---|---|
| Hlavní autori: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Basel, Switzerland
2020
|
| Predmet: | |
| ISSN: | 1018-8665, 1421-9832, 1421-9832 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders. Objectives: To determine the delay in HS diagnosis and its consequences for patients and the healthcare system. Methods: This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated. Results: The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians – most frequently general practitioners, dermatologists, surgeons, gynecologists – and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed. Conclusion: This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. |
|---|---|
| AbstractList | Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders.
To determine the delay in HS diagnosis and its consequences for patients and the healthcare system.
This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated.
The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians - most frequently general practitioners, dermatologists, surgeons, gynecologists - and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed.
This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders. Objectives: To determine the delay in HS diagnosis and its consequences for patients and the healthcare system. Methods: This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated. Results: The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians – most frequently general practitioners, dermatologists, surgeons, gynecologists – and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed. Conclusion: This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders.BACKGROUNDHidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of skin architecture, HS patients experience metabolic, musculoskeletal, and psychological disorders.To determine the delay in HS diagnosis and its consequences for patients and the healthcare system.OBJECTIVESTo determine the delay in HS diagnosis and its consequences for patients and the healthcare system.This was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated.METHODSThis was a prospective, multicenter, epidemiologic, non-interventional cross-sectional trial carried out in Germany and based on self-reported questionnaires and medical examinations performed by dermatologists. In total, data of 394 adult HS patients were evaluated.The average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians - most frequently general practitioners, dermatologists, surgeons, gynecologists - and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed.RESULTSThe average duration from manifestation of first symptoms until HS diagnosis was 10.0 ± 9.6 (mean ± SD) years. During this time, HS patients consulted on average more than 3 different physicians - most frequently general practitioners, dermatologists, surgeons, gynecologists - and faced more than 3 misdiagnoses. Diagnosis delay was longer in younger and non-smoking patients. In most cases, HS was correctly diagnosed by dermatologists. The longer the delay of diagnosis, the greater the disease severity at diagnosis. Delayed HS diagnosis was also associated with an increased number of surgically treated sites, concomitant diseases, and days of work missed.This study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people.CONCLUSIONThis study demonstrates an enormous delay in the diagnosis of HS, which results in more severe disease. It also shows for the first time that a delay in diagnosis of a chronic inflammatory disease leads to a higher number of concomitant systemic disorders. In addition to the impaired health status, delayed diagnosis of HS was associated with impairment of the professional life of affected people. |
| Author | Barbus, Sebastian Kalus, Stefanie Gomis-Kleindienst, Susana Kokolakis, Georgios Sabat, Robert Wolk, Kerstin Schneider-Burrus, Sylke |
| Author_xml | – sequence: 1 givenname: Georgios surname: Kokolakis fullname: Kokolakis, Georgios – sequence: 2 givenname: Kerstin surname: Wolk fullname: Wolk, Kerstin – sequence: 3 givenname: Sylke surname: Schneider-Burrus fullname: Schneider-Burrus, Sylke – sequence: 4 givenname: Stefanie surname: Kalus fullname: Kalus, Stefanie – sequence: 5 givenname: Sebastian surname: Barbus fullname: Barbus, Sebastian – sequence: 6 givenname: Susana surname: Gomis-Kleindienst fullname: Gomis-Kleindienst, Susana – sequence: 7 givenname: Robert surname: Sabat fullname: Sabat, Robert email: *Robert Sabat, Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité – Universitätsmedizin Berlin, Charitéplatz 1, DE–10117 Berlin (Germany), robert.sabat@charite.de |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32610312$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkD1PwzAQhi1URD9gYEfIEgtLwB-J44yoLbRSEYjCSuTYlxJInRAnSP33GKUwMd3d-zy64R2jga0sIHRKyRWlUXJNCImIjGV8gEY0ZDRIJGcDvxMqAylENERj5969xmScHKEhZ4ISTtkIvc6gVDsweFaoja1c4XCV40VhGmXAFq2_111dd41qiy-FlTV42To8z3PQLa4sfvQArI9-0AJU2b5p1QBe71wL22N0mKvSwcl-TtDL7fx5ughWD3fL6c0q0GFC2kACoXGseJJRJSPGtYgIy4nIOFPMEBoCFybMhJCGag2QZFEc6UgACBkylfAJuuz_1k312YFr023hNJSlslB1LmUhTWLKJWVePd-rXbYFk9ZNsVXNLv3txAtnvfChmg00f0JfsccX_-LZ031vpLXJ-TdhKXiQ |
| CitedBy_id | crossref_primary_10_1007_s00105_021_04843_z crossref_primary_10_3389_fimmu_2023_1281685 crossref_primary_10_1111_jdv_20861 crossref_primary_10_1186_s12913_024_11923_y crossref_primary_10_1093_bjd_ljae469 crossref_primary_10_1007_s40271_021_00539_7 crossref_primary_10_1007_s00403_024_03716_4 crossref_primary_10_1177_1759720X20975915 crossref_primary_10_1111_bjd_20523 crossref_primary_10_1111_apm_70049 crossref_primary_10_1155_2023_3640285 crossref_primary_10_1177_12034754231223451 crossref_primary_10_1111_ddg_15411 crossref_primary_10_1111_ddg_15412 crossref_primary_10_1111_ijcp_14186 crossref_primary_10_1111_1346_8138_17874 crossref_primary_10_1111_ddg_15412_g crossref_primary_10_1016_j_jaad_2023_04_058 crossref_primary_10_1016_j_jaci_2020_12_651 crossref_primary_10_2147_CCID_S301794 crossref_primary_10_1007_s13555_025_01496_x crossref_primary_10_1159_000540359 crossref_primary_10_1111_ddg_15541 crossref_primary_10_1111_jdv_20575 crossref_primary_10_1111_ddg_15541_g crossref_primary_10_36290_der_2025_008 crossref_primary_10_3389_fmedt_2024_1200400 crossref_primary_10_1007_s00403_024_03622_9 crossref_primary_10_20344_amp_18916 crossref_primary_10_1093_bjd_ljaf277 crossref_primary_10_1002_jvc2_70071 crossref_primary_10_1016_j_jemermed_2022_08_001 crossref_primary_10_3389_fmed_2022_875492 crossref_primary_10_1016_j_ad_2024_10_019 crossref_primary_10_1111_bjd_20654 crossref_primary_10_1097_DSS_0000000000004349 crossref_primary_10_4081_jphr_2021_2706 crossref_primary_10_1007_s13555_024_01259_0 crossref_primary_10_1002_jvc2_237 crossref_primary_10_1111_ijd_16835 crossref_primary_10_3390_clinpract14050135 crossref_primary_10_1159_000538444 crossref_primary_10_1111_jdv_20044 crossref_primary_10_1111_ajd_13672 crossref_primary_10_1177_12034754231188452 crossref_primary_10_3390_jcm11237240 crossref_primary_10_2196_69030 crossref_primary_10_3389_fmed_2024_1403455 crossref_primary_10_1016_j_jaad_2024_10_073 crossref_primary_10_1002_der2_125 crossref_primary_10_1159_000542381 crossref_primary_10_1016_j_det_2024_12_015 crossref_primary_10_3390_healthcare11243139 crossref_primary_10_2340_actadv_v104_32746 crossref_primary_10_1111_jdv_20607 crossref_primary_10_1016_j_clindermatol_2023_08_022 crossref_primary_10_1016_S0140_6736_23_00022_3 crossref_primary_10_1097_JW9_0000000000000130 crossref_primary_10_1111_ijd_16428 crossref_primary_10_3389_fmed_2025_1626345 crossref_primary_10_1007_s40257_024_00911_x crossref_primary_10_1016_j_jnma_2022_08_002 crossref_primary_10_1016_j_ad_2023_10_051 crossref_primary_10_1111_ddg_14934_g crossref_primary_10_2147_CCID_S463861 crossref_primary_10_1093_bjd_ljad028 crossref_primary_10_1007_s00403_025_04016_1 crossref_primary_10_1111_exd_14338 crossref_primary_10_1016_j_jid_2024_04_014 crossref_primary_10_18553_jmcp_2025_24317 crossref_primary_10_4103_NJM_NJM_67_23 crossref_primary_10_1055_a_2225_7983 crossref_primary_10_1159_000540423 crossref_primary_10_1007_s13555_025_01426_x crossref_primary_10_1016_j_xjidi_2025_100362 crossref_primary_10_1159_000543130 crossref_primary_10_1016_j_jdin_2022_08_023 crossref_primary_10_1111_ddg_14886_g crossref_primary_10_3389_fmed_2022_1028943 crossref_primary_10_1159_000540422 crossref_primary_10_1111_ddg_14886 crossref_primary_10_1111_ced_14468 crossref_primary_10_1016_j_amjmed_2022_09_025 crossref_primary_10_1001_jamadermatol_2022_4610 crossref_primary_10_1016_j_jaad_2024_09_008 crossref_primary_10_1159_000516308 crossref_primary_10_1007_s00105_021_04853_x crossref_primary_10_1089_jir_2023_0105 crossref_primary_10_3389_fgene_2022_962449 crossref_primary_10_1016_j_det_2024_12_002 crossref_primary_10_1093_ced_llae353 crossref_primary_10_1007_s13555_024_01291_0 crossref_primary_10_1016_j_jid_2024_04_035 crossref_primary_10_1093_bjd_ljae262 crossref_primary_10_3390_jcm14082625 crossref_primary_10_3390_polym13162770 crossref_primary_10_1080_14656566_2022_2070429 crossref_primary_10_1007_s00403_024_03787_3 crossref_primary_10_1007_s13555_025_01462_7 crossref_primary_10_1111_exd_70163 crossref_primary_10_1007_s13555_025_01407_0 crossref_primary_10_1371_journal_pone_0310651 crossref_primary_10_3389_fmed_2024_1499509 crossref_primary_10_1111_ddg_14934 crossref_primary_10_1007_s11136_020_02732_x crossref_primary_10_1111_apm_13304 crossref_primary_10_1001_jamadermatol_2022_4564 crossref_primary_10_17116_klinderma202524031255 crossref_primary_10_1111_jdv_16783 crossref_primary_10_1111_pde_16033 crossref_primary_10_1111_1346_8138_17386 crossref_primary_10_2340_actadv_v103_6569 crossref_primary_10_3389_fmed_2024_1384055 crossref_primary_10_1111_bjd_21247 crossref_primary_10_1111_pde_15983 crossref_primary_10_1093_bjd_ljac027 crossref_primary_10_1111_ajd_13870 crossref_primary_10_7759_cureus_56231 crossref_primary_10_1016_S0140_6736_24_02475_9 crossref_primary_10_3390_ijms23169057 crossref_primary_10_1007_s10875_023_01518_3 crossref_primary_10_1111_bjd_19556 crossref_primary_10_1111_ddg_15411_g crossref_primary_10_12968_jowc_2025_34_Sup7b_S1 crossref_primary_10_3390_nu15173797 crossref_primary_10_1159_000542343 crossref_primary_10_1007_s40271_022_00614_7 crossref_primary_10_2340_1651_226X_2024_26182 crossref_primary_10_1016_j_jid_2025_04_009 crossref_primary_10_1007_s00105_024_05321_y crossref_primary_10_1016_j_clindermatol_2025_05_007 crossref_primary_10_1002_cpt_3632 crossref_primary_10_1007_s00403_023_02578_6 crossref_primary_10_1016_j_jdcr_2023_11_012 crossref_primary_10_1111_jdv_20234 crossref_primary_10_3390_healthcare12181849 crossref_primary_10_1093_bjd_ljad345 crossref_primary_10_3390_life13081630 crossref_primary_10_1159_000518540 crossref_primary_10_12968_bjon_2022_31_4_S34 crossref_primary_10_1136_bmj_2021_068383 crossref_primary_10_3390_jcm14093171 crossref_primary_10_1097_JW9_0000000000000064 crossref_primary_10_1111_jdv_18163 |
| ContentType | Journal Article |
| Copyright | 2020 The Author(s) Published by S. Karger AG, Basel 2020 The Author(s) Published by S. Karger AG, Basel. |
| Copyright_xml | – notice: 2020 The Author(s) Published by S. Karger AG, Basel – notice: 2020 The Author(s) Published by S. Karger AG, Basel. |
| DBID | M-- CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1159/000508787 |
| DatabaseName | Karger Open Access Journals Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: M-- name: Karger Open Access Journals url: https://www.karger.com/OpenAccess sourceTypes: Enrichment Source Publisher – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1421-9832 |
| EndPage | 430 |
| ExternalDocumentID | 32610312 508787 |
| Genre | Multicenter Study Journal Article |
| GeographicLocations | Germany |
| GeographicLocations_xml | – name: Germany |
| GroupedDBID | --- .55 .GJ 0R~ 0~5 0~B 1CY 29F 30W 328 34G 36B 39C 3O- 3O. 3V. 4.4 53G 5GY 5RE 7RV 7X7 88E 8AO 8FI 8FJ 8FW 8G5 8UI AAWTL AAYIC ABJNI ABPAZ ABUWG ACGFS ACPRK ACPSR ADAGL ADBBV AENEX AEYAO AFDXO AFFNX AFJJK AFKRA AFRAH AHMBA ALDHI ALIPV ALMA_UNASSIGNED_HOLDINGS AZPMC AZQEC BENPR BKEYQ BPHCQ BVXVI CAG CCPQU COF CS3 CYUIP DU5 DWQXO E0A EBS EJD EMB EMOBN EX3 F5P FB. FYUFA GNUQQ GUQSH HMCUK HZ~ IY7 KUZGX L7B M-- M1P M2O N9A NAPCQ O1H O9- P2P PQQKQ PROAC PSQYO RIG RKO RXVBD SV3 UJ6 UKHRP WOW X7M ZGI ZXP ABBTS ABWCG ACQXL AFSIO AHFRZ CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c490t-8e0177a39b1a8523c6502f06b32a2d014e36d4b668d1ccee9b575c56ee6842a93 |
| IEDL.DBID | M-- |
| ISICitedReferencesCount | 163 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000565796100003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1018-8665 1421-9832 |
| IngestDate | Thu Oct 02 10:51:28 EDT 2025 Wed Feb 19 02:06:50 EST 2025 Thu Sep 05 17:58:08 EDT 2024 Thu Aug 29 12:04:43 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Healthcare system Diagnosis Acne inversa Hidradenitis suppurativa Comorbidity |
| Language | English |
| License | This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. 2020 The Author(s) Published by S. Karger AG, Basel. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c490t-8e0177a39b1a8523c6502f06b32a2d014e36d4b668d1ccee9b575c56ee6842a93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://karger.com/doi/10.1159/000508787 |
| PMID | 32610312 |
| PQID | 2419713812 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_2419713812 pubmed_primary_32610312 karger_primary_508787 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-00-00 |
| PublicationDateYYYYMMDD | 2020-01-01 |
| PublicationDate_xml | – year: 2020 text: 2020-00-00 |
| PublicationDecade | 2020 |
| PublicationPlace | Basel, Switzerland |
| PublicationPlace_xml | – name: Basel, Switzerland – name: Switzerland |
| PublicationTitle | Dermatology (Basel) |
| PublicationTitleAlternate | Dermatology |
| PublicationYear | 2020 |
| References | Theut Riis P, Thorlacius L, Knudsen List E, Jemec GB. A pilot study of unemployment in patients with hidradenitis suppurativa in Denmark. Br J Dermatol. 2017Apr;176(4):1083–5. 10.1111/bjd.14922274806110007-0963 Miller IM, Ellervik C, Vinding GR, Zarchi K, Ibler KS, Knudsen KM, et al.. Association of metabolic syndrome and hidradenitis suppurativa. JAMA Dermatol. 2014Dec;150(12):1273–80. 10.1001/jamadermatol.2014.1165252299962168-6068 Sabat R, Jemec GB, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020Mar;6(1):18. 10.1038/s41572-020-0149-1321656202056-676X Schneider-Burrus S, Jost A, Peters EM, Witte-Haendel E, Sterry W, Sabat R. Association of Hidradenitis Suppurativa With Body Image. JAMA Dermatol. 2018Apr;154(4):447–51. 10.1001/jamadermatol.2017.6058294665462168-6068 Richette P, Molto A, Viguier M, Dawidowicz K, Hayem G, Nassif A, et al.. Hidradenitis suppurativa associated with spondyloarthritis— results from a multicenter national prospective study. J Rheumatol. 2014Mar;41(3):490–4. 10.3899/jrheum.130977244291660315-162X Boehncke WH. Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: causes and Consequences. Front Immunol. 2018Apr;9:579. 10.3389/fimmu.2018.00579296750201664-3224 Kromann CB, Deckers IE, Esmann S, Boer J, Prens EP, Jemec GB. Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study. Br J Dermatol. 2014Oct;171(4):819–24. 10.1111/bjd.13090248046040007-0963 Ritz JP, Runkel N, Haier J, Buhr HJ. Extent of surgery and recurrence rate of hidradenitis suppurativa. Int J Colorectal Dis. 1998;13(4):164–8. 10.1007/s00384005015998105200179-1958 Garg A, Papagermanos V, Midura M, Strunk A. Incidence of hidradenitis suppurativa among tobacco smokers: a population-based retrospective analysis in the U.S.A. Br J Dermatol. 2018Mar;178(3):709–14. 10.1111/bjd.15939289602350007-0963 Taams LS, Steel KJ, Srenathan U, Burns LA, Kirkham BW. IL-17 in the immunopathogenesis of spondyloarthritis. Nat Rev Rheumatol. 2018Aug;14(8):453–66. 10.1038/s41584-018-0044-2300066011759-4790 Saunte DM, Boer J, Stratigos A, Szepietowski JC, Hamzavi I, Kim KH, et al.. Diagnostic delay in hidradenitis suppurativa is a global problem. Br J Dermatol. 2015Dec;173(6):1546–9. 10.1111/bjd.14038261981910007-0963 Ingram JR, Jenkins-Jones S, Knipe DW, Morgan CL, Cannings-John R, Piguet V. Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa. Br J Dermatol. 2018Apr;178(4):917–24. 10.1111/bjd.16101290943460007-0963 Karagiannidis I, Nikolakis G, Sabat R, Zouboulis CC. Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder. Rev Endocr Metab Disord. 2016Sep;17(3):335–41. 10.1007/s11154-016-9366-z272945931389-9155 Wolk K, Wenzel J, Tsaousi A, Witte-Händel E, Babel N, Zelenak C, et al.. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Br J Dermatol. 2017Nov;177(5):1385–93. 10.1111/bjd.15424282567180007-0963 Khalsa A, Liu G, Kirby JS. Increased utilization of emergency department and inpatient care by patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Oct;73(4):609–14. 10.1016/j.jaad.2015.06.053261902410190-9622 Kurek A, Peters EM, Chanwangpong A, Sabat R, Sterry W, Schneider-Burrus S. Profound disturbances of sexual health in patients with acne inversa. J Am Acad Dermatol. 2012;67(3):422-8, 8 e1. Matusiak L, Bieniek A, Szepietowski JC. Hidradenitis suppurativa markedly decreases quality of life and professional activity. J Am Acad Dermatol. 2010;62(4):706-8, 8 e1. Hessam S, Sand M, Gambichler T, Skrygan M, Rüddel I, Bechara FG. Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop. Br J Dermatol. 2018Mar;178(3):761–7. 10.1111/bjd.16019289756260007-0963 Schneider-Burrus S, Witte-Haendel E, Christou D, Rigoni B, Sabat R, Diederichs G. High Prevalence of Back Pain and Axial Spondyloarthropathy in Patients with Hidradenitis Suppurativa. Dermatology. 2016;232(5):606–12. 10.1159/000448838276494171018-8665 Tsaousi A, Witte E, Witte K, Röwert-Huber HJ, Volk HD, Sterry W, et al.. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators Inflamm. 2016;2016:4097574. 10.1155/2016/4097574278432000962-9351 van der Zee HH, de Ruiter L, van den Broecke DG, Dik WA, Laman JD, Prens EP. Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β. Br J Dermatol. 2011Jun;164(6):1292–8. 10.1111/j.1365-2133.2011.10254.x213324640007-0963 Lima AL, Karl I, Giner T, Poppe H, Schmidt M, Presser D, et al.. Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa. Br J Dermatol. 2016Mar;174(3):514–21. 10.1111/bjd.14214264365220007-0963 Elnabawi YA, Dey AK, Goyal A, Groenendyk JW, Chung JH, Belur AD, et al.. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovasc Res. 2019Mar;115(4):721–8. 10.1093/cvr/cvz009307219330008-6363 Wolkenstein P, Loundou A, Barrau K, Auquier P, Revuz J; Quality of Life Group of the French Society of Dermatology. Quality of life impairment in hidradenitis suppurativa: a study of 61 cases. J Am Acad Dermatol. 2007Apr;56(4):621–3. 10.1016/j.jaad.2006.08.061170973660190-9622 Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, et al.. Increased prevalence of metabolic syndrome in patients with acne inversa. PLoS One. 2012;7(2):e31810. 10.1371/journal.pone.0031810223596341932-6203 Deckers IE, Janse IC, van der Zee HH, Nijsten T, Boer J, Horvath B, et al. Hidradenitis suppurativa (HS) is associated with low socioeconomic status (SES): A cross-sectional reference study. J Am Acad Dermatol. 2016;75(4):755-9 e1. Piaserico S, Osto E, Famoso G, Zanetti I, Gregori D, Poretto A, et al.. Treatment with tumor necrosis factor inhibitors restores coronary microvascular function in young patients with severe psoriasis. Atherosclerosis. 2016Aug;251:25–30. 10.1016/j.atherosclerosis.2016.05.036272363530021-9150 Loget J, Saint-Martin C, Guillem P, Kanagaratnam L, Becherel PA, Nassif A, et al.; sous l’égide de « ResoVerneil ». [Misdiagnosis of hidradenitis suppurativa continues to be a major issue. The R-ENS Verneuil study]. Ann Dermatol Venereol. 2018May;145(5):331–8. 10.1016/j.annder.2018.01.043297049580151-9638 Egeberg A, Gislason GH, Hansen PR. Risk of Major Adverse Cardiovascular Events and All-Cause Mortality in Patients With Hidradenitis Suppurativa. JAMA Dermatol. 2016Apr;152(4):429–34. 10.1001/jamadermatol.2015.6264268857282168-6068 Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S, Witte K, et al.. Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. J Immunol. 2011Jan;186(2):1228–39. 10.4049/jimmunol.0903907211480410022-1767 Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mößner R, Shomroni O, et al.. The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction. J Invest Dermatol. 2019Jun;139(6):1294–305. 10.1016/j.jid.2018.11.018305288240022-202X Horváth B, Janse IC, Sibbald GR. Pain management in patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Nov;73(5Suppl 1):S47–51. 10.1016/j.jaad.2015.07.046264706160190-9622 Sabat R, Wolk K, Loyal L, Döcke WD, Ghoreschi K. T cell pathology in skin inflammation. Semin Immunopathol. 2019May;41(3):359–77. 10.1007/s00281-019-00742-7310284341863-2297 |
| References_xml | – reference: Schneider-Burrus S, Jost A, Peters EM, Witte-Haendel E, Sterry W, Sabat R. Association of Hidradenitis Suppurativa With Body Image. JAMA Dermatol. 2018Apr;154(4):447–51. 10.1001/jamadermatol.2017.6058294665462168-6068 – reference: Ritz JP, Runkel N, Haier J, Buhr HJ. Extent of surgery and recurrence rate of hidradenitis suppurativa. Int J Colorectal Dis. 1998;13(4):164–8. 10.1007/s00384005015998105200179-1958 – reference: Wolk K, Wenzel J, Tsaousi A, Witte-Händel E, Babel N, Zelenak C, et al.. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Br J Dermatol. 2017Nov;177(5):1385–93. 10.1111/bjd.15424282567180007-0963 – reference: Kromann CB, Deckers IE, Esmann S, Boer J, Prens EP, Jemec GB. Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: a cross-sectional study. Br J Dermatol. 2014Oct;171(4):819–24. 10.1111/bjd.13090248046040007-0963 – reference: Hessam S, Sand M, Gambichler T, Skrygan M, Rüddel I, Bechara FG. Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop. Br J Dermatol. 2018Mar;178(3):761–7. 10.1111/bjd.16019289756260007-0963 – reference: Kurek A, Peters EM, Chanwangpong A, Sabat R, Sterry W, Schneider-Burrus S. Profound disturbances of sexual health in patients with acne inversa. J Am Acad Dermatol. 2012;67(3):422-8, 8 e1. – reference: Karagiannidis I, Nikolakis G, Sabat R, Zouboulis CC. Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder. Rev Endocr Metab Disord. 2016Sep;17(3):335–41. 10.1007/s11154-016-9366-z272945931389-9155 – reference: Ingram JR, Jenkins-Jones S, Knipe DW, Morgan CL, Cannings-John R, Piguet V. Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa. Br J Dermatol. 2018Apr;178(4):917–24. 10.1111/bjd.16101290943460007-0963 – reference: Tsaousi A, Witte E, Witte K, Röwert-Huber HJ, Volk HD, Sterry W, et al.. MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations. Mediators Inflamm. 2016;2016:4097574. 10.1155/2016/4097574278432000962-9351 – reference: Miller IM, Ellervik C, Vinding GR, Zarchi K, Ibler KS, Knudsen KM, et al.. Association of metabolic syndrome and hidradenitis suppurativa. JAMA Dermatol. 2014Dec;150(12):1273–80. 10.1001/jamadermatol.2014.1165252299962168-6068 – reference: Boehncke WH. Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: causes and Consequences. Front Immunol. 2018Apr;9:579. 10.3389/fimmu.2018.00579296750201664-3224 – reference: Elnabawi YA, Dey AK, Goyal A, Groenendyk JW, Chung JH, Belur AD, et al.. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovasc Res. 2019Mar;115(4):721–8. 10.1093/cvr/cvz009307219330008-6363 – reference: Wolkenstein P, Loundou A, Barrau K, Auquier P, Revuz J; Quality of Life Group of the French Society of Dermatology. Quality of life impairment in hidradenitis suppurativa: a study of 61 cases. J Am Acad Dermatol. 2007Apr;56(4):621–3. 10.1016/j.jaad.2006.08.061170973660190-9622 – reference: Schneider-Burrus S, Witte-Haendel E, Christou D, Rigoni B, Sabat R, Diederichs G. High Prevalence of Back Pain and Axial Spondyloarthropathy in Patients with Hidradenitis Suppurativa. Dermatology. 2016;232(5):606–12. 10.1159/000448838276494171018-8665 – reference: Horváth B, Janse IC, Sibbald GR. Pain management in patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Nov;73(5Suppl 1):S47–51. 10.1016/j.jaad.2015.07.046264706160190-9622 – reference: Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S, Witte K, et al.. Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. J Immunol. 2011Jan;186(2):1228–39. 10.4049/jimmunol.0903907211480410022-1767 – reference: Loget J, Saint-Martin C, Guillem P, Kanagaratnam L, Becherel PA, Nassif A, et al.; sous l’égide de « ResoVerneil ». [Misdiagnosis of hidradenitis suppurativa continues to be a major issue. The R-ENS Verneuil study]. Ann Dermatol Venereol. 2018May;145(5):331–8. 10.1016/j.annder.2018.01.043297049580151-9638 – reference: van der Zee HH, de Ruiter L, van den Broecke DG, Dik WA, Laman JD, Prens EP. Elevated levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-α and IL-1β. Br J Dermatol. 2011Jun;164(6):1292–8. 10.1111/j.1365-2133.2011.10254.x213324640007-0963 – reference: Lima AL, Karl I, Giner T, Poppe H, Schmidt M, Presser D, et al.. Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa. Br J Dermatol. 2016Mar;174(3):514–21. 10.1111/bjd.14214264365220007-0963 – reference: Piaserico S, Osto E, Famoso G, Zanetti I, Gregori D, Poretto A, et al.. Treatment with tumor necrosis factor inhibitors restores coronary microvascular function in young patients with severe psoriasis. Atherosclerosis. 2016Aug;251:25–30. 10.1016/j.atherosclerosis.2016.05.036272363530021-9150 – reference: Deckers IE, Janse IC, van der Zee HH, Nijsten T, Boer J, Horvath B, et al. Hidradenitis suppurativa (HS) is associated with low socioeconomic status (SES): A cross-sectional reference study. J Am Acad Dermatol. 2016;75(4):755-9 e1. – reference: Sabat R, Wolk K, Loyal L, Döcke WD, Ghoreschi K. T cell pathology in skin inflammation. Semin Immunopathol. 2019May;41(3):359–77. 10.1007/s00281-019-00742-7310284341863-2297 – reference: Theut Riis P, Thorlacius L, Knudsen List E, Jemec GB. A pilot study of unemployment in patients with hidradenitis suppurativa in Denmark. Br J Dermatol. 2017Apr;176(4):1083–5. 10.1111/bjd.14922274806110007-0963 – reference: Khalsa A, Liu G, Kirby JS. Increased utilization of emergency department and inpatient care by patients with hidradenitis suppurativa. J Am Acad Dermatol. 2015Oct;73(4):609–14. 10.1016/j.jaad.2015.06.053261902410190-9622 – reference: Garg A, Papagermanos V, Midura M, Strunk A. Incidence of hidradenitis suppurativa among tobacco smokers: a population-based retrospective analysis in the U.S.A. Br J Dermatol. 2018Mar;178(3):709–14. 10.1111/bjd.15939289602350007-0963 – reference: Matusiak L, Bieniek A, Szepietowski JC. Hidradenitis suppurativa markedly decreases quality of life and professional activity. J Am Acad Dermatol. 2010;62(4):706-8, 8 e1. – reference: Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mößner R, Shomroni O, et al.. The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction. J Invest Dermatol. 2019Jun;139(6):1294–305. 10.1016/j.jid.2018.11.018305288240022-202X – reference: Egeberg A, Gislason GH, Hansen PR. Risk of Major Adverse Cardiovascular Events and All-Cause Mortality in Patients With Hidradenitis Suppurativa. JAMA Dermatol. 2016Apr;152(4):429–34. 10.1001/jamadermatol.2015.6264268857282168-6068 – reference: Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, et al.. Increased prevalence of metabolic syndrome in patients with acne inversa. PLoS One. 2012;7(2):e31810. 10.1371/journal.pone.0031810223596341932-6203 – reference: Saunte DM, Boer J, Stratigos A, Szepietowski JC, Hamzavi I, Kim KH, et al.. Diagnostic delay in hidradenitis suppurativa is a global problem. Br J Dermatol. 2015Dec;173(6):1546–9. 10.1111/bjd.14038261981910007-0963 – reference: Richette P, Molto A, Viguier M, Dawidowicz K, Hayem G, Nassif A, et al.. Hidradenitis suppurativa associated with spondyloarthritis— results from a multicenter national prospective study. J Rheumatol. 2014Mar;41(3):490–4. 10.3899/jrheum.130977244291660315-162X – reference: Sabat R, Jemec GB, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020Mar;6(1):18. 10.1038/s41572-020-0149-1321656202056-676X – reference: Taams LS, Steel KJ, Srenathan U, Burns LA, Kirkham BW. IL-17 in the immunopathogenesis of spondyloarthritis. Nat Rev Rheumatol. 2018Aug;14(8):453–66. 10.1038/s41584-018-0044-2300066011759-4790 |
| SSID | ssj0002879 |
| Score | 2.6055841 |
| Snippet | Background: Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and... Hidradenitis suppurativa (HS) is a neglected chronic inflammatory disease with long delay in diagnosis. Besides pain, purulent discharge, and destruction of... |
| SourceID | proquest pubmed karger |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 421 |
| SubjectTerms | Adolescent Adult Age of Onset Aged Comorbidity Cross-Sectional Studies Delayed Diagnosis - psychology Delayed Diagnosis - statistics & numerical data Delivery of Health Care Depression - etiology Dermatologic Surgical Procedures - statistics & numerical data Diagnostic Errors - statistics & numerical data Employment - statistics & numerical data Female Germany - epidemiology Hidradenitis Suppurativa - diagnosis Hidradenitis Suppurativa - epidemiology Hidradenitis Suppurativa - surgery Humans Male Middle Aged Non-Smokers - statistics & numerical data Prospective Studies Referral and Consultation - statistics & numerical data Research Article Severity of Illness Index Time Factors Young Adult |
| Title | Delayed Diagnosis of Hidradenitis Suppurativa and Its Effect on Patients and Healthcare System |
| URI | https://karger.com/doi/10.1159/000508787 https://www.ncbi.nlm.nih.gov/pubmed/32610312 https://www.proquest.com/docview/2419713812 |
| Volume | 236 |
| WOSCitedRecordID | wos000565796100003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dS8MwED_clLEXP6dW54jga2D9WNo8inNMsGOIyp4saZPBUNqxboL_vZekFhQGvvShIU3JXXK_y11-B3DDBynLmCupkG5AA5kGlM-VpDJiA6XxtDC3-F8fw8kkms34tDrv0Hdh3nX-s6FGrbkF0OCa0nP9CJWrAbtocM0SjCmt91zE_dzENd2Iaga3ikPoV9c2tBCr6LIGHpobO9B2XGnsy-jg_392CPsVhiS3VuhHsKPyY2jFVZT8BN6G6kN8KUmGNo9uUZJiTsYLuRK4y2gSI6KLeW4M6bcgIpfkYV0SS2RMipxMLdlqaZrGdYYYsfTmHXgZ3T_fjWlVR4FmAe-vaaRw2YXC56krInQ8M0Rl3rzPUt8TnkQfSflMBiljkXQzNJo8RQyXDZhSOkgnuH8KzbzI1TmQFL0_V99t1dFaprkIXS_1hRShj36Tzx3o2HlKlpYsI7GT40D3z_vhU2ybkqWcO3D9I4YE1VvHLESuik2ZIMDg6EcjDHHgzMqn_sSPNC-2DHoJbU97x-bApAvN9WqjrmAv-8R5XvWgEc6inlEjfE6m8TefBb4q |
| linkProvider | Karger AG |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dS8MwED90iu7Fz6nVqRF8DaxfafMoztHhNoZM2ZMlbTIYSjf2Ifjfe0m6gcLA14YmJXfN_S539zuAex5mLGeupEK6AQ1kFlA-UpLKmIVK42lhqvjfOlGvFw-HvF_ed-hamA-d_2yoUdfcAmhwTeu5RozKtQ07EQ89rctdStdnLuJ-buKabkw1g1vJIfTr1SrsIVbRbQ08NDd2oc240tiX1uH_v-wIDkoMSR6s0I9hSxUnsNcto-Sn8N5Un-JbSdK0eXTjOZmMSDKWM4GnjCYxIrqZ59KQfgsiCknaizmxRMZkUpC-JVudm6FknSFGLL15DV5bT4PHhJZ9FGge8MaCxgp_u0j4PHNFjI5njqjMGzVY5nvCk-gjKZ_JIGMslm6ORpNniOHykCmlg3SC-2dQKSaFugCSoffn6tpWHa1lmovQ9TJfSBH56Df53IGa3ad0askyUrs5DtT_PG--dO1QOpUjB-5WYkhRvXXMQhRqspynCDA4-tEIQxw4t_JZT7GS5uWGRW9hPxl0O2mn3Xu-gqqnPWVzeVKHymK2VNewm3_hns9ujDL9ANOcvy8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Delayed+Diagnosis+of+Hidradenitis+Suppurativa+and+Its+Effect+on+Patients+and+Healthcare+System&rft.jtitle=Dermatology+%28Basel%29&rft.au=Kokolakis%2C+Georgios&rft.au=Wolk%2C+Kerstin&rft.au=Schneider-Burrus%2C+Sylke&rft.au=Kalus%2C+Stefanie&rft.date=2020&rft.issn=1018-8665&rft.eissn=1421-9832&rft.volume=236&rft.issue=5&rft.spage=421&rft.epage=430&rft_id=info:doi/10.1159%2F000508787&rft_id=info%3Apmid%2F32610312&rft.externalDocID=508787 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1018-8665&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1018-8665&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1018-8665&client=summon |