Local Field Potentials: Myths and Misunderstandings

The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered...

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Vydáno v:	Frontiers in neural circuits Ročník 10; s. 101
Hlavní autor:	Herreras, Oscar
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Research Foundation 15.12.2016 Frontiers Media S.A
Témata:	Animals Biophysics Biophysics - standards Brain - physiology cell assembly EEG Electric currents Electroencephalography Electrophysiological Phenomena Electrophysiological recording Geometry Humans Independent Component Analysis Local Field Potentials Nerve Net - physiology Neural networks Neurons Neuroscience Neurosciences Neurosciences - standards Polarity Recording equipment Researchers Spatial Discrimination spontaneous activity Synchronization cell assembly EEG volume-conduction spatial discrimination spontaneous activity network oscillations local field potentials neuronal circuits
ISSN:	1662-5110, 1662-5110
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Popis
Shrnutí:	The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confounding factors and technical limitations. By and large, the main factor defining the amplitude of LFPs is the geometry of the current sources, over and above the degree of synchronization or the properties of the media. As such, similar levels of activity may result in potentials that differ in several orders of magnitude in different populations. The geometry of these sources has been experimentally inaccessible until intracerebral high density recordings enabled the co-activating sources to be revealed. Without this information, it has proven difficult to interpret a century's worth of recordings that used temporal cues alone, such as event or spike related potentials and frequency bands. Meanwhile, a collection of biophysically ill-founded concepts have been considered legitimate, which can now be corrected in the light of recent advances. The relationship of LFPs to their sources is often counterintuitive. For instance, most LFP activity is not local but remote, it may be larger further from rather than close to the source, the polarity does not define its excitatory or inhibitory nature, and the amplitude may increase when source's activity is reduced. As technological developments foster the use of LFPs, the time is now ripe to raise awareness of the need to take into account spatial aspects of these signals and of the errors derived from neglecting to do so.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Reviewed by: Alain Destexhe, Unité de Neurosciences, Information and Complexité, Centre National de la Recherche Scientifique, France; Vikaas Singh Sohal, University of California, San Francisco, USA Edited by: Michael M. Halassa, New York University, USA
ISSN:	1662-5110 1662-5110
DOI:	10.3389/fncir.2016.00101