Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories

The wealth of accurately curated sequence data for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), its long genome, and its low substitution rate provides a relatively blank canvas with which to investigate effects of mutational and editing processes imposed by the host cell. The findi...

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Bibliographic Details
Published in:	mSphere Vol. 5; no. 3
Main Author:	Simmonds, P.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 24.06.2020
Subjects:	Amino acid sequence Antiretroviral drugs Antiviral drugs APOBEC APOBEC Deaminases Asymmetry Base Composition - genetics Base Sequence - genetics Betacoronavirus - genetics Coronaviridae coronavirus Coronavirus Infections - pathology Coronaviruses COVID-19 Cytidine Deaminase - genetics Cytosine - analysis Datasets Disease transmission Divergence Ecological and Evolutionary Science Epidemics Epidemiology Evolution Genome, Viral - genetics Genomes Humans hypermutation Long-term effects Mathematical models Middle East Respiratory Syndrome Coronavirus - genetics Molecular modelling Mutation Pandemics Pneumonia, Viral - pathology Polymorphism, Single Nucleotide - genetics Reversion RNA polymerase SARS SARS coronavirus 2 SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus - genetics Uracil - analysis Zoonoses COVID-19 SARS-CoV-2 APOBEC SARS coronavirus SARS coronavirus 2 hypermutation
ISSN:	2379-5042, 2379-5042
Online Access:	Get full text
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