Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung

Ventilator-associated pneumonia (VAP) is characterized by neutrophils infiltrating the alveolar space. VAP is associated with high mortality, and accurate diagnosis remains difficult. We hypothesized that proteolytic enzymes from neutrophils would be significantly increased and locally produced inhi...

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Veröffentlicht in:	Chest Jg. 142; H. 6; S. 1425
Hauptverfasser:	Wilkinson, Thomas S, Conway Morris, Andrew, Kefala, Kallirroi, O'Kane, Cecilia M, Moore, Norma R, Booth, Nuala A, McAuley, Daniel F, Dhaliwal, Kevin, Walsh, Timothy S, Haslett, Christopher, Sallenave, Jean-Michel, Simpson, A John
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2012
Schlagworte:	Adult Aged Aged, 80 and over Bronchoalveolar Lavage Fluid Case-Control Studies Cell Movement Diagnosis, Differential Female Humans Lung - enzymology Lung - pathology Male Matrix Metalloproteinase 8 - metabolism Matrix Metalloproteinase 9 - metabolism Middle Aged Neutrophils - enzymology Neutrophils - pathology Pancreatic Elastase - metabolism Peptide Hydrolases - metabolism Pneumonia, Ventilator-Associated - diagnosis Pneumonia, Ventilator-Associated - enzymology Pneumonia, Ventilator-Associated - pathology Tissue Inhibitor of Metalloproteinases - metabolism
ISSN:	1931-3543, 1931-3543
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