Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation derivative of indirubin, has general water solubility and is well-tolerated. Previous studies have shown that meisoindigo reduces infl...

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Veröffentlicht in:	Frontiers in cellular neuroscience Jg. 13; S. 553
Hauptverfasser:	Ye, Yingze, Jin, Tong, Zhang, Xu, Zeng, Zhi, Ye, Baixin, Wang, Jinchen, Zhong, Yi, Xiong, Xiaoxing, Gu, Lijuan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Research Foundation 16.12.2019 Frontiers Media S.A
Schlagworte:	Apoptosis Brain injury Cell activation Cell cycle Cerebral blood flow Chemotaxis Cytokines Cytotoxicity Edema HMGB1 protein Homeostasis IL-1β Immunofluorescence Inflammasomes Inflammation Ischemia ischemic stroke Kinases Leukocyte migration Lipopolysaccharides Macrophages Microglia microglia/macrophage polarization Neuroscience new therapies NF-κB protein NLRP3 inflammasome Phenotypes Polarization Proteins Reperfusion Signal transduction Stroke TLR4 protein toll-like receptor 4 Toll-like receptors Traumatic brain injury China microglia/macrophage polarization new therapies NLRP3 inflammasome toll-like receptor 4 ischemic stroke
ISSN:	1662-5102, 1662-5102
Online-Zugang:	Volltext
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