Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data

Antibiotic drug consumption is a major driver of antibiotic resistance. Variations in antibiotic resistance across countries are attributable, in part, to different volumes and patterns for antibiotic consumption. We aimed to assess variations in consumption to assist monitoring of the rise of resis...

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Bibliographic Details
Published in:The Lancet infectious diseases Vol. 14; no. 8; pp. 742 - 750
Main Authors: Van Boeckel, Thomas P, Gandra, Sumanth, Ashok, Ashvin, Caudron, Quentin, Grenfell, Bryan T, Levin, Simon A, Laxminarayan, Ramanan
Format: Journal Article
Language:English
Published: London Elsevier Ltd 01.08.2014
Lancet Publishing Group
Elsevier Limited
Subjects:
Algorithms
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotic resistance
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Commerce - statistics & numerical data
Consumption
Data analysis
Decomposition
Developing countries
Drug resistance
Drug Utilization - standards
Drug Utilization - statistics & numerical data
Estimates
Global Health
Health Policy
Hospitals
Humans
Infectious Disease
Infectious diseases
LDCs
Medical sciences
Mortality
National security
Pharmaceutical industry
Pharmacology. Drug treatments
Population
Public health
Statistical methods
Time series
Antibacterial agent
Antibiotic
ISSN:1473-3099, 1474-4457, 1474-4457
Online Access:Get full text
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Summary:Antibiotic drug consumption is a major driver of antibiotic resistance. Variations in antibiotic resistance across countries are attributable, in part, to different volumes and patterns for antibiotic consumption. We aimed to assess variations in consumption to assist monitoring of the rise of resistance and development of rational-use policies and to provide a baseline for future assessment. With use of sales data for retail and hospital pharmacies from the IMS Health MIDAS database, we reviewed trends for consumption of standard units of antibiotics between 2000 and 2010 for 71 countries. We used compound annual growth rates to assess temporal differences in consumption for each country and Fourier series and regression methods to assess seasonal differences in consumption in 63 of the countries. Between 2000 and 2010, consumption of antibiotic drugs increased by 35% (from 52 057 163 835 standard units to 70 440 786 553). Brazil, Russia, India, China, and South Africa accounted for 76% of this increase. In most countries, antibiotic consumption varied significantly with season. There was increased consumption of carbapenems (45%) and polymixins (13%), two last-resort classes of antibiotic drugs. The rise of antibiotic consumption and the increase in use of last-resort antibiotic drugs raises serious concerns for public health. Appropriate use of antibiotics in developing countries should be encouraged. However, to prevent a striking rise in resistance in low-income and middle-income countries with large populations and to preserve antibiotic efficacy worldwide, programmes that promote rational use through coordinated efforts by the international community should be a priority. US Department of Homeland Security, Bill & Melinda Gates Foundation, US National Institutes of Health, Princeton Grand Challenges Program.
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ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(14)70780-7