Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug development, as it can address previously inaccessible targets. However, degrader discovery and optimization remains an inefficient process due to...

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Vydáno v:	Cell Ročník 183; číslo 6; s. 1714
Hlavní autoři:	Donovan, Katherine A, Ferguson, Fleur M, Bushman, Jonathan W, Eleuteri, Nicholas A, Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D, Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P, Ghobrial, Irene M, Ma, Michelle W, Che, Jianwei, Buhrlage, Sara J, Sim, Taebo, Gray, Nathanael S, Fischer, Eric S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 10.12.2020
Témata:	Adult Cell Line Databases, Protein Female Humans Male Middle Aged Proteasome Endopeptidase Complex - metabolism Protein Kinases - genetics Protein Kinases - metabolism Proteolysis Proteome - metabolism Proteomics RNA, Messenger - genetics RNA, Messenger - metabolism Ubiquitin-Protein Ligases - metabolism Young Adult kinase E3 ligase PROTAC ubiquitin proteasome system targeted degradation IMiD degrader ubiquitin
ISSN:	1097-4172, 1097-4172
On-line přístup:	Zjistit podrobnosti o přístupu
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