TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry

SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal transmembrane protein, can serve as an alternative receptor for SARS-CoV-2 entry into angiotensin-converting enzyme 2 (...

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Bibliographic Details
Published in:	Cell Vol. 186; no. 16; p. 3427
Main Authors:	Baggen, Jim, Jacquemyn, Maarten, Persoons, Leentje, Vanstreels, Els, Pye, Valerie E, Wrobel, Antoni G, Calvaresi, Valeria, Martin, Stephen R, Roustan, Chloë, Cronin, Nora B, Reading, Eamonn, Thibaut, Hendrik Jan, Vercruysse, Thomas, Maes, Piet, De Smet, Frederik, Yee, Angie, Nivitchanyong, Toey, Roell, Marina, Franco-Hernandez, Natalia, Rhinn, Herve, Mamchak, Alusha Andre, Ah Young-Chapon, Maxime, Brown, Eric, Cherepanov, Peter, Daelemans, Dirk
Format:	Journal Article
Language:	English
Published:	United States 03.08.2023
Subjects:	Angiotensin-Converting Enzyme 2 - metabolism COVID-19 Humans Membrane Proteins - metabolism Nerve Tissue Proteins - metabolism Protein Binding Receptors, Virus - metabolism SARS-CoV-2 - metabolism Virus Internalization SARS-CoV-2 TMEM106B crystal structure ACE2-independent entry antibody neutralization TMEM106B coronavirus cryo-EM entry receptor
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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