Bacteria Challenge in Smoke-exposed Mice Exacerbates Inflammation and Skews the Inflammatory Profile

The pathogenesis of chronic obstructive pulmonary disease is associated with acute episodes of bacterial exacerbations. The most commonly isolated bacteria during episodes of exacerbation is nontypeable Haemophilus influenzae (NTHI). In this study, we investigated the in vivo consequences of cigaret...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 179; no. 8; pp. 666 - 675
Main Authors:	Gaschler, Gordon J, Skrtic, Marko, Zavitz, Caleb C. J, Lindahl, Maria, Onnervik, Per-Ola, Murphy, Timothy F, Sethi, Sanjay, Stampfli, Martin R
Format:	Journal Article
Language:	English
Published:	New York, NY Am Thoracic Soc 15.04.2009 American Thoracic Society
Subjects:	Administration, Intranasal Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Bacteria Bacterial infections Biological and medical sciences Chronic obstructive pulmonary disease Cigarettes Disease Progression Emergency and intensive care: infection, septic shock Female Haemophilus influenzae Haemophilus influenzae - immunology Inflammation Inflammation - etiology Inflammation - microbiology Intensive care medicine Lungs Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Pathogenesis Pulmonary Disease, Chronic Obstructive - immunology Pulmonary Disease, Chronic Obstructive - microbiology Smoking Steroids Tobacco Smoke Pollution - adverse effects Tumor necrosis factor-TNF Canada Lung disease Intensive care mouse model Respiratory disease Rodentia Inflammation Haemophilus influenzae exacerbation Pasteurellaceae Vertebrata Mammalia Mouse Animal nontypeable Haemophilus influenzae Bacteria Bronchus disease Chronic obstructive pulmonary disease Resuscitation
ISSN:	1073-449X, 1535-4970, 1535-4970
Online Access:	Get full text
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