A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects
A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB) deoxycholate (0.7 mg/kg per day, with the placebo/AmB component given only for the first 5-6 days) as therapy for candidemia due to species other tha...
Saved in:
| Published in: | Clinical infectious diseases Vol. 36; no. 10; p. 1221 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
15.05.2003
|
| Subjects: | |
| ISSN: | 1537-6591, 1537-6591 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB) deoxycholate (0.7 mg/kg per day, with the placebo/AmB component given only for the first 5-6 days) as therapy for candidemia due to species other than Candida krusei in adults without neutropenia. A total of 219 patients met criteria for a modified intent-to-treat analysis. The groups were similar except that those who were treated with fluconazole plus placebo had a higher mean (+/- standard error) Acute Physiology and Chronic Health Evaluation II score (16.8+/-0.6 vs. 15.0+/-0.7; P=.039). Success rates on study day 30 by Kaplan-Meier time-to-failure analysis were 57% for fluconazole plus placebo and 69% for fluconazole plus AmB (P=.08). Overall success rates were 56% (60 of 107 patients) and 69% (77 of 112 patients; P=.043), respectively; the bloodstream infection failed to clear in 17% and 6% of subjects, respectively (P=.02). In nonneutropenic subjects, the combination of fluconazole plus AmB was not antagonistic compared with fluconazole alone, and the combination trended toward improved success and more-rapid clearance from the bloodstream. |
|---|---|
| AbstractList | A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB) deoxycholate (0.7 mg/kg per day, with the placebo/AmB component given only for the first 5-6 days) as therapy for candidemia due to species other than Candida krusei in adults without neutropenia. A total of 219 patients met criteria for a modified intent-to-treat analysis. The groups were similar except that those who were treated with fluconazole plus placebo had a higher mean (+/- standard error) Acute Physiology and Chronic Health Evaluation II score (16.8+/-0.6 vs. 15.0+/-0.7; P=.039). Success rates on study day 30 by Kaplan-Meier time-to-failure analysis were 57% for fluconazole plus placebo and 69% for fluconazole plus AmB (P=.08). Overall success rates were 56% (60 of 107 patients) and 69% (77 of 112 patients; P=.043), respectively; the bloodstream infection failed to clear in 17% and 6% of subjects, respectively (P=.02). In nonneutropenic subjects, the combination of fluconazole plus AmB was not antagonistic compared with fluconazole alone, and the combination trended toward improved success and more-rapid clearance from the bloodstream.A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB) deoxycholate (0.7 mg/kg per day, with the placebo/AmB component given only for the first 5-6 days) as therapy for candidemia due to species other than Candida krusei in adults without neutropenia. A total of 219 patients met criteria for a modified intent-to-treat analysis. The groups were similar except that those who were treated with fluconazole plus placebo had a higher mean (+/- standard error) Acute Physiology and Chronic Health Evaluation II score (16.8+/-0.6 vs. 15.0+/-0.7; P=.039). Success rates on study day 30 by Kaplan-Meier time-to-failure analysis were 57% for fluconazole plus placebo and 69% for fluconazole plus AmB (P=.08). Overall success rates were 56% (60 of 107 patients) and 69% (77 of 112 patients; P=.043), respectively; the bloodstream infection failed to clear in 17% and 6% of subjects, respectively (P=.02). In nonneutropenic subjects, the combination of fluconazole plus AmB was not antagonistic compared with fluconazole alone, and the combination trended toward improved success and more-rapid clearance from the bloodstream. A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB) deoxycholate (0.7 mg/kg per day, with the placebo/AmB component given only for the first 5-6 days) as therapy for candidemia due to species other than Candida krusei in adults without neutropenia. A total of 219 patients met criteria for a modified intent-to-treat analysis. The groups were similar except that those who were treated with fluconazole plus placebo had a higher mean (+/- standard error) Acute Physiology and Chronic Health Evaluation II score (16.8+/-0.6 vs. 15.0+/-0.7; P=.039). Success rates on study day 30 by Kaplan-Meier time-to-failure analysis were 57% for fluconazole plus placebo and 69% for fluconazole plus AmB (P=.08). Overall success rates were 56% (60 of 107 patients) and 69% (77 of 112 patients; P=.043), respectively; the bloodstream infection failed to clear in 17% and 6% of subjects, respectively (P=.02). In nonneutropenic subjects, the combination of fluconazole plus AmB was not antagonistic compared with fluconazole alone, and the combination trended toward improved success and more-rapid clearance from the bloodstream. |
| Author | Stein, David K Cleary, John D Brass, Corstiaan Bradsher, Robert W Hilton, Eileen Goodman, Jesse Lee, Jeannette Edwards, John E Schuster, Mindy Rex, John H Rubin, Robert H Washburn, Ronald G Zervos, Marcus Panzer, Helene Horowitz, Harold W Mautner, Linda Chu, Teng-Chiao McKinsey, David Lutz, Jon Babinchak, Timothy Sobel, Jack Kett, Daniel H Hyslop, Newton E Chapman, Stanley W Hadley, Susan Danziger, Larry Rosenstein, Rebecca B Pappas, Peter G Goldman, Mitchell Karchmer, Adolf W Simmons, Bryan Scheld, W Michael Booth, Jenia Vazquez, Jose A Cohen, David M |
| Author_xml | – sequence: 1 givenname: John H surname: Rex fullname: Rex, John H email: john@rexweb.org organization: Division of Infectious Diseases, University of Texas Medical School, Houston, TX 77030, USA. john@rexweb.org – sequence: 2 givenname: Peter G surname: Pappas fullname: Pappas, Peter G – sequence: 3 givenname: Adolf W surname: Karchmer fullname: Karchmer, Adolf W – sequence: 4 givenname: Jack surname: Sobel fullname: Sobel, Jack – sequence: 5 givenname: John E surname: Edwards fullname: Edwards, John E – sequence: 6 givenname: Susan surname: Hadley fullname: Hadley, Susan – sequence: 7 givenname: Corstiaan surname: Brass fullname: Brass, Corstiaan – sequence: 8 givenname: Jose A surname: Vazquez fullname: Vazquez, Jose A – sequence: 9 givenname: Stanley W surname: Chapman fullname: Chapman, Stanley W – sequence: 10 givenname: Harold W surname: Horowitz fullname: Horowitz, Harold W – sequence: 11 givenname: Marcus surname: Zervos fullname: Zervos, Marcus – sequence: 12 givenname: David surname: McKinsey fullname: McKinsey, David – sequence: 13 givenname: Jeannette surname: Lee fullname: Lee, Jeannette – sequence: 14 givenname: Timothy surname: Babinchak fullname: Babinchak, Timothy – sequence: 15 givenname: Robert W surname: Bradsher fullname: Bradsher, Robert W – sequence: 16 givenname: John D surname: Cleary fullname: Cleary, John D – sequence: 17 givenname: David M surname: Cohen fullname: Cohen, David M – sequence: 18 givenname: Larry surname: Danziger fullname: Danziger, Larry – sequence: 19 givenname: Mitchell surname: Goldman fullname: Goldman, Mitchell – sequence: 20 givenname: Jesse surname: Goodman fullname: Goodman, Jesse – sequence: 21 givenname: Eileen surname: Hilton fullname: Hilton, Eileen – sequence: 22 givenname: Newton E surname: Hyslop fullname: Hyslop, Newton E – sequence: 23 givenname: Daniel H surname: Kett fullname: Kett, Daniel H – sequence: 24 givenname: Jon surname: Lutz fullname: Lutz, Jon – sequence: 25 givenname: Robert H surname: Rubin fullname: Rubin, Robert H – sequence: 26 givenname: W Michael surname: Scheld fullname: Scheld, W Michael – sequence: 27 givenname: Mindy surname: Schuster fullname: Schuster, Mindy – sequence: 28 givenname: Bryan surname: Simmons fullname: Simmons, Bryan – sequence: 29 givenname: David K surname: Stein fullname: Stein, David K – sequence: 30 givenname: Ronald G surname: Washburn fullname: Washburn, Ronald G – sequence: 31 givenname: Linda surname: Mautner fullname: Mautner, Linda – sequence: 32 givenname: Teng-Chiao surname: Chu fullname: Chu, Teng-Chiao – sequence: 33 givenname: Helene surname: Panzer fullname: Panzer, Helene – sequence: 34 givenname: Rebecca B surname: Rosenstein fullname: Rosenstein, Rebecca B – sequence: 35 givenname: Jenia surname: Booth fullname: Booth, Jenia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12746765$$D View this record in MEDLINE/PubMed |
| BookMark | eNplUE1PHDEMjdAiPhb6EyqfuA1NMpP5OC4ISiWkXsp5lUkcNiiTDEmmEvvv-GdEQKVKXOxn-fn52adk5YNHQr4xeslo3_6ou6YX9ICcMFF3VSsGtvoPH5PTlJ4oZayn4ogcM941bdeKE_K6gSi9DpPdo4aCYHTW64KnxWWr0GeMkKOVDoKBnX3cVTokBOMWFbzcB4cwuyWVIBWOAf5iTKX80pfTvAtFzCrr4QpkgrzDKOcXMCGCKqutxsnKdxM2JyjjCZ8X9AoTlJlyscclxzCjtwrSMj6hyumMHBrpEp5_5jV5uL35c31X3f_--et6c1-pph9yJTgOAjWXXDKtmk7otjeyZbXhlDc1G4xqdDMYNOMgasl1zzutBY5131KtkK_JxYfuHENxlfJ2skmhc9JjWNK2q2sq2NAV4vdP4jJOqLdztJOML9t_T-dvI5CKFQ |
| CitedBy_id | crossref_primary_10_1128_AAC_48_9_3312_3316_2004 crossref_primary_10_1097_01_CCM_0000231883_93001_E0 crossref_primary_10_4103_0255_0857_99484 crossref_primary_10_1586_14787210_2_2_269 crossref_primary_10_1128_AAC_48_6_2021_2024_2004 crossref_primary_10_1007_s15010_017_1042_z crossref_primary_10_1016_j_clp_2014_10_010 crossref_primary_10_1111_j_1439_0507_2004_01003_x crossref_primary_10_1111_ijcp_13655 crossref_primary_10_1186_cc8117 crossref_primary_10_2165_00003495_200565110_00002 crossref_primary_10_1016_j_earlhumdev_2011_01_014 crossref_primary_10_1016_S1441_2772_23_00886_4 crossref_primary_10_1086_520980 crossref_primary_10_1097_00062752_200311000_00009 crossref_primary_10_1056_NEJMe078078 crossref_primary_10_1093_jac_dkh434 crossref_primary_10_1111_j_1399_3062_2010_00492_x crossref_primary_10_1111_j_1439_0507_2006_01231_x crossref_primary_10_1128_AAC_48_9_3317_3322_2004 crossref_primary_10_1016_j_revmed_2009_02_027 crossref_primary_10_1056_NEJMra1315399 crossref_primary_10_1007_s00277_008_0622_5 crossref_primary_10_1097_QCO_0000000000001063 crossref_primary_10_1111_j_1439_0507_2010_01885_x crossref_primary_10_1016_S0140_6736_07_60605_9 crossref_primary_10_1016_S1473_3099_03_00801_6 crossref_primary_10_1185_030079907X182130 crossref_primary_10_1086_503043 crossref_primary_10_1128_JCM_00605_14 crossref_primary_10_1517_14656566_7_3_307 crossref_primary_10_1097_MD_0000000000004474 crossref_primary_10_1517_14656566_8_10_1479 crossref_primary_10_1517_14728214_11_2_231 crossref_primary_10_1016_j_emcmi_2005_04_001 crossref_primary_10_1053_j_seminhematol_2009_03_003 crossref_primary_10_1097_MCC_0000000000000758 crossref_primary_10_1016_j_jinf_2007_06_012 crossref_primary_10_1128_AAC_49_12_5058_5068_2005 crossref_primary_10_1586_eri_13_29 crossref_primary_10_1016_j_bjid_2013_02_001 crossref_primary_10_1111_myc_13082 crossref_primary_10_1097_01_qco_0000235164_70678_97 crossref_primary_10_1517_17425255_2011_615309 crossref_primary_10_1128_AAC_01510_09 crossref_primary_10_1007_s11046_009_9193_9 crossref_primary_10_1007_s40588_015_0017_z crossref_primary_10_1592_phco_23_14_1441_31938 crossref_primary_10_1177_0885066609355262 crossref_primary_10_1093_cid_cis021 crossref_primary_10_1097_01_CCM_0000201897_78123_44 crossref_primary_10_1111_myc_13406 crossref_primary_10_1177_0897190007311010 crossref_primary_10_1007_s12281_008_0007_1 crossref_primary_10_7554_eLife_00662 crossref_primary_10_1093_jac_dkz038 crossref_primary_10_1016_j_cmi_2020_03_030 crossref_primary_10_2165_11315590_000000000_00000 crossref_primary_10_1517_14656566_9_6_927 crossref_primary_10_1586_14787210_2_2_253 crossref_primary_10_1186_1471_2334_11_261 crossref_primary_10_1086_587101 crossref_primary_10_1177_20499361211039050 crossref_primary_10_1016_S0924_8579_08_70014_1 crossref_primary_10_1517_14656566_6_15_2617 crossref_primary_10_1007_s12281_010_0039_1 crossref_primary_10_1111_j_1445_5994_2008_01725_x crossref_primary_10_1111_1469_0691_12041 crossref_primary_10_1111_1469_0691_12040 crossref_primary_10_1080_13693780500049152 crossref_primary_10_1586_14787210_5_5_883 crossref_primary_10_1111_1469_0691_12039 crossref_primary_10_1111_j_1439_0507_2011_02040_x crossref_primary_10_1128_AAC_48_3_970_978_2004 crossref_primary_10_1093_jac_dkae175 crossref_primary_10_1016_j_burns_2010_01_005 crossref_primary_10_1128_JCM_02048_13 crossref_primary_10_1016_j_arth_2017_03_030 crossref_primary_10_1016_j_ijantimicag_2013_04_008 crossref_primary_10_1111_jocs_12258 crossref_primary_10_3109_10428194_2012_745073 crossref_primary_10_1542_peds_2006_2931 crossref_primary_10_3390_jof4030097 crossref_primary_10_1016_j_idc_2015_10_013 crossref_primary_10_1016_S0924_8579_08_70013_X crossref_primary_10_1007_s00277_004_0986_0 crossref_primary_10_1038_sj_jp_7211300 crossref_primary_10_1086_528715 crossref_primary_10_1111_j_1365_2141_2007_06906_x crossref_primary_10_1146_annurev_med_59_062906_071602 crossref_primary_10_3816_SCT_2004_n_019 crossref_primary_10_1016_j_clml_2020_08_010 crossref_primary_10_1592_phco_28_5_614 crossref_primary_10_2147_tcrm_2007_3_1_71 crossref_primary_10_1016_j_ajic_2007_08_001 crossref_primary_10_1128_cmr_00074_23 crossref_primary_10_1586_eri_10_141 crossref_primary_10_1007_s12223_013_0234_x crossref_primary_10_1111_j_1445_5994_2008_01726_x crossref_primary_10_1097_01_cpm_0000133342_99319_1a crossref_primary_10_1016_j_biopha_2018_12_009 crossref_primary_10_1086_376906 crossref_primary_10_1016_j_pcl_2005_02_009 crossref_primary_10_1093_ajhp_62_suppl_1_S17 crossref_primary_10_1093_cid_ciy830 crossref_primary_10_1007_s00134_008_1339_6 crossref_primary_10_2146_ajhp050464_p2 crossref_primary_10_1007_s11908_007_0069_1 crossref_primary_10_1128_AAC_00791_10 crossref_primary_10_1128_AAC_05035_14 crossref_primary_10_1111_j_1600_6143_2009_02909_x crossref_primary_10_1002_pds_1073 crossref_primary_10_1007_s10096_005_0025_7 crossref_primary_10_1586_14787210_5_1_129 crossref_primary_10_1177_152692480401400206 crossref_primary_10_1007_s00277_005_0048_2 crossref_primary_10_1007_s12281_010_0014_x crossref_primary_10_1097_QCO_0b013e3283177967 crossref_primary_10_1517_14656560802560005 crossref_primary_10_1016_j_clinthera_2005_08_007 crossref_primary_10_1517_14656566_9_2_175 crossref_primary_10_2217_17460913_2_2_115 crossref_primary_10_1099_jmm_0_46548_0 crossref_primary_10_1016_j_revmed_2005_03_003 crossref_primary_10_1007_s11046_006_0025_x crossref_primary_10_1128_AAC_47_10_3149_3154_2003 crossref_primary_10_1089_sur_2005_6_55 crossref_primary_10_1111_myc_70041 crossref_primary_10_1086_423391 crossref_primary_10_1086_374856 crossref_primary_10_1093_jac_dkn154 crossref_primary_10_1177_0018578718802583 crossref_primary_10_1016_j_jobcr_2020_06_009 crossref_primary_10_1038_sj_bmt_1705687 crossref_primary_10_1586_14787210_4_4_675 crossref_primary_10_1007_s00277_013_1867_1 crossref_primary_10_1111_myc_13290 crossref_primary_10_1007_s11046_021_00599_1 crossref_primary_10_3390_jof8020115 crossref_primary_10_2165_11206200_000000000_00000 crossref_primary_10_3390_jof7020108 crossref_primary_10_1128_CMR_18_1_163_194_2005 crossref_primary_10_2165_10898550_000000000_00000 crossref_primary_10_1093_jpids_piab024 crossref_primary_10_1080_13693780701436794 crossref_primary_10_1086_502451 crossref_primary_10_1086_589858 crossref_primary_10_1111_j_1365_2141_2004_05007_x crossref_primary_10_1053_j_semperi_2007_01_006 crossref_primary_10_1007_s00347_009_1925_1 crossref_primary_10_1111_j_1439_0507_2008_01629_x crossref_primary_10_1086_503428 crossref_primary_10_1016_j_diagmicrobio_2013_11_012 crossref_primary_10_1056_NEJMoa066906 crossref_primary_10_1007_s10096_005_0024_8 crossref_primary_10_1016_j_ccc_2010_11_001 crossref_primary_10_1097_INF_0b013e31819f1f50 crossref_primary_10_1111_j_1439_0507_2007_01379_x crossref_primary_10_1586_14787210_5_6_1019 crossref_primary_10_1111_j_1469_0691_2008_01983_x crossref_primary_10_1016_S0924_8579_08_70007_4 crossref_primary_10_1007_s10096_004_1215_4 crossref_primary_10_1086_421951 crossref_primary_10_1007_s11908_008_0076_x crossref_primary_10_1111_ajt_12114 crossref_primary_10_1007_s00101_015_0072_0 crossref_primary_10_1086_591428 crossref_primary_10_1097_00001432_200412000_00002 crossref_primary_10_1016_S1473_3099_03_00831_4 crossref_primary_10_1016_j_idc_2010_01_002 crossref_primary_10_1080_14787210_2021_1941868 crossref_primary_10_1517_14656566_8_8_1155 crossref_primary_10_1111_imj_12600 crossref_primary_10_1517_13543784_13_9_1183 crossref_primary_10_1093_jac_dkm169 crossref_primary_10_1111_ctr_13623 crossref_primary_10_1179_joc_2008_20_1_137 crossref_primary_10_1007_s12281_020_00387_2 crossref_primary_10_1097_QCO_0b013e328010851d crossref_primary_10_1007_s12281_008_0017_z crossref_primary_10_1086_421960 crossref_primary_10_1086_421961 crossref_primary_10_1086_421962 crossref_primary_10_1111_j_1439_0507_2010_01881_x crossref_primary_10_1177_11786337211026927 crossref_primary_10_3389_fimmu_2023_1292625 crossref_primary_10_1093_mmy_myy029 crossref_primary_10_1586_14787210_4_1_137 crossref_primary_10_1592_phco_26_6part2_61S crossref_primary_10_1002_cmdc_201500271 crossref_primary_10_1016_j_bbmt_2003_09_014 crossref_primary_10_1093_jac_dki473 crossref_primary_10_1099_jmm_0_078709_0 crossref_primary_10_1177_0897190004273474 crossref_primary_10_1016_j_ijantimicag_2011_11_017 crossref_primary_10_1093_cid_cit061 crossref_primary_10_1093_mmy_myy019 crossref_primary_10_1177_0897190004273471 crossref_primary_10_1016_j_clinmicnews_2006_11_001 crossref_primary_10_1586_14787210_2_3_357 crossref_primary_10_1128_AAC_01324_10 crossref_primary_10_1111_j_1469_0691_2007_01710_x crossref_primary_10_1093_cid_civ933 crossref_primary_10_1002_ardp_201400084 crossref_primary_10_1080_21548331_2018_1508290 crossref_primary_10_1007_s40121_020_00382_7 crossref_primary_10_1016_S1413_8670_12_70336_7 crossref_primary_10_1086_429330 crossref_primary_10_3390_microorganisms6040123 crossref_primary_10_1016_S1130_6343_05_73677_1 crossref_primary_10_1016_j_riam_2014_11_006 crossref_primary_10_1128_AAC_48_3_693_715_2004 crossref_primary_10_1128_AAC_01657_09 crossref_primary_10_1128_AAC_02019_20 crossref_primary_10_1007_s11908_006_0015_7 crossref_primary_10_1007_s00134_014_3281_0 crossref_primary_10_1111_j_1439_0507_2008_01571_x crossref_primary_10_3390_jof7090731 crossref_primary_10_1080_14740338_2017_1270264 crossref_primary_10_1016_j_mam_2025_101347 crossref_primary_10_1177_2049936114562586 crossref_primary_10_1016_j_idc_2006_07_004 crossref_primary_10_3810_hp_2010_04_298 crossref_primary_10_1016_j_drup_2003_08_003 crossref_primary_10_1097_00001432_200312000_00005 crossref_primary_10_1097_00043426_200405000_00009 crossref_primary_10_1128_AAC_02031_20 crossref_primary_10_1016_j_amjmed_2007_04_001 crossref_primary_10_1016_j_hoc_2010_11_013 crossref_primary_10_1016_j_idc_2024_11_007 crossref_primary_10_1016_j_jinf_2009_08_020 crossref_primary_10_1128_JCM_00179_11 crossref_primary_10_1111_j_1474_7766_2004_00254_x crossref_primary_10_1016_j_diagmicrobio_2012_02_004 crossref_primary_10_1111_j_1469_0691_2008_01981_x crossref_primary_10_1128_AAC_00205_13 crossref_primary_10_1097_01_CCM_0000143020_27340_FF crossref_primary_10_1016_j_idc_2020_05_003 crossref_primary_10_1111_j_1444_0903_2004_00569_x crossref_primary_10_1016_S0140_6736_05_67490_9 crossref_primary_10_1007_s10156_007_0522_Y crossref_primary_10_1038_s41572_024_00503_3 crossref_primary_10_1111_j_1469_0691_2012_03784_x crossref_primary_10_7182_prtr_14_2_d8526452qt422v52 crossref_primary_10_1056_NEJMc071981 crossref_primary_10_1128_CMR_19_2_435_447_2006 crossref_primary_10_1111_j_1469_0691_2011_03615_x crossref_primary_10_7717_peerj_4999 crossref_primary_10_1007_s11908_011_0204_x crossref_primary_10_1016_S0140_6736_05_67381_3 crossref_primary_10_1086_432939 crossref_primary_10_1586_14787210_4_5_875 crossref_primary_10_1073_pnas_0609370104 crossref_primary_10_1128_JCM_01602_10 crossref_primary_10_7326_M13_2508 crossref_primary_10_1111_myc_12104 crossref_primary_10_1128_AAC_50_4_1567_1569_2006 crossref_primary_10_1007_s12281_009_0032_8 crossref_primary_10_1086_428677 crossref_primary_10_3390_jof8101077 crossref_primary_10_1007_s00277_003_0767_1 crossref_primary_10_1086_596757 crossref_primary_10_1517_14656566_7_9_1181 crossref_primary_10_1177_10600280231175201 crossref_primary_10_1086_380796 crossref_primary_10_1111_imj_15587 crossref_primary_10_1007_s11894_015_0436_2 crossref_primary_10_4065_83_9_1011 crossref_primary_10_2217_17460913_3_6_603 crossref_primary_10_1097_01_qco_0000399605_75891_fc crossref_primary_10_1097_01_qco_0000235166_16421_e5 crossref_primary_10_1086_528692 crossref_primary_10_1016_S1130_1406_08_70028_7 crossref_primary_10_1007_s12281_020_00369_4 crossref_primary_10_1128_AAC_00574_07 crossref_primary_10_1111_1469_0691_12622 crossref_primary_10_1128_JCM_00356_06 crossref_primary_10_1016_j_blre_2006_03_001 crossref_primary_10_1016_j_jiph_2013_08_002 crossref_primary_10_1517_14656566_9_16_2801 crossref_primary_10_1007_s00101_009_1655_4 crossref_primary_10_1016_j_jinf_2007_01_014 crossref_primary_10_1002_cncr_20573 crossref_primary_10_1016_j_clindermatol_2011_09_018 crossref_primary_10_1586_14787210_2015_1058157 crossref_primary_10_1093_jac_dkx445 crossref_primary_10_1007_s10156_007_0595_7 crossref_primary_10_1111_j_1469_0691_2006_01606_x crossref_primary_10_1586_eri_11_5 crossref_primary_10_1093_jac_dkn304 crossref_primary_10_1128_AAC_49_9_3616_3623_2005 crossref_primary_10_1080_13693780310001616528 crossref_primary_10_1111_j_1469_0691_2005_01318_x crossref_primary_10_1016_j_arcmed_2005_05_015 crossref_primary_10_1080_13693780701218689 crossref_primary_10_1097_01_inf_0000145408_51526_0a crossref_primary_10_1007_s12281_010_0018_6 crossref_primary_10_1016_j_idc_2021_03_007 crossref_primary_10_1097_MCC_0b013e32833e84d2 crossref_primary_10_1128_AAC_49_8_3171_3177_2005 crossref_primary_10_1016_j_ccm_2009_02_013 crossref_primary_10_1053_j_ackd_2006_04_008 |
| ContentType | Journal Article |
| CorporateAuthor | National Institute of Allergy and Infectious Diseases Mycoses Study Group |
| CorporateAuthor_xml | – name: National Institute of Allergy and Infectious Diseases Mycoses Study Group |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1086/374850 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1537-6591 |
| ExternalDocumentID | 12746765 |
| Genre | Comparative Study Clinical Trial Research Support, Non-U.S. Gov't Multicenter Study Research Support, U.S. Gov't, P.H.S Randomized Controlled Trial Journal Article |
| GrantInformation_xml | – fundername: PHS HHS grantid: N01-AL-65296 |
| GroupedDBID | --- ..I .2P .GJ .I3 .ZR 08P 0R~ 1TH 29B 2AX 2WC 36B 3O- 4.4 48X 53G 5GY 5RE 5VS 5WD 6J9 AABZA AACGO AACZT AAJKP AAJQQ AAMVS AANCE AAOGV AAPQZ AAPXW AAQQT AARHZ AAUAY AAUQX AAVAP AAYOK ABBHK ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABLJU ABNGD ABNHQ ABOCM ABPLY ABPTD ABQLI ABQNK ABTLG ABVGC ABWST ABXSQ ABXVV ACGFO ACGFS ACHIC ACPRK ACUFI ACUTO ACYHN ADBBV ADGZP ADHKW ADHZD ADIPN ADJQC ADQBN ADRIX ADRTK ADULT ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEUPB AEWNT AEXZC AFFNX AFFZL AFIYH AFOFC AFRAH AFXAL AFXEN AGINJ AGQXC AGSYK AGUTN AHMBA AHMMS AHXPO AI. AIAGR AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN AQKUS AQVQM ASPBG ATGXG AVWKF AXUDD AZFZN BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM C1A C45 CDBKE CGR CS3 CUY CVF CZ4 DAKXR DCCCD DIK DILTD DOOOF DU5 D~K E3Z EBS ECM EE~ EIF EJD EMOBN ENERS ESX F5P F9B FECEO FEDTE FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC H5~ HAR HQ3 HTVGU HVGLF HW0 HZ~ IOX IPSME J21 J5H JAAYA JBMMH JENOY JHFFW JKQEH JLS JLXEF JPM JSG JSODD JST KAQDR KBUDW KOP KSI KSN L7B M49 MHKGH MJL ML0 N4W N9A NGC NOMLY NOYVH NPM NU- NVLIB O0~ O9- OAUYM OAWHX OCZFY ODMLO ODZKP OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P P6G PAFKI PB- PEELM PQQKQ Q1. Q5Y QBD RD5 ROX ROZ RUSNO RW1 RXO SA0 SJN TCURE TEORI TJX TMA TR2 VH1 W8F X7H YAYTL YKOAZ YXANX ZGI ~91 ~S- 7X8 ABPQP ACUKT ADNBA ADQXQ AEMQT AGQPQ AJBYB AJNCP ALXQX JXSIZ |
| ID | FETCH-LOGICAL-c489t-52e95ed2a2a1dc475d68fa613f2024319fc4d49fefb953a2d827dd5eb3860dce2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 343 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000182872200003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1537-6591 |
| IngestDate | Sun Nov 09 10:38:56 EST 2025 Wed Feb 19 01:31:13 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c489t-52e95ed2a2a1dc475d68fa613f2024319fc4d49fefb953a2d827dd5eb3860dce2 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://academic.oup.com/cid/article-pdf/36/10/1221/6055601/36-10-1221.pdf |
| PMID | 12746765 |
| PQID | 73305197 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_73305197 pubmed_primary_12746765 |
| PublicationCentury | 2000 |
| PublicationDate | 2003-May-15 20030515 |
| PublicationDateYYYYMMDD | 2003-05-15 |
| PublicationDate_xml | – month: 05 year: 2003 text: 2003-May-15 day: 15 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Clinical infectious diseases |
| PublicationTitleAlternate | Clin Infect Dis |
| PublicationYear | 2003 |
| References | 12746766 - Clin Infect Dis. 2003 May 15;36(10):1229-31 |
| References_xml | – reference: 12746766 - Clin Infect Dis. 2003 May 15;36(10):1229-31 |
| SSID | ssj0011805 |
| Score | 2.3175638 |
| Snippet | A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B (AmB)... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1221 |
| SubjectTerms | Adult Amphotericin B - adverse effects Amphotericin B - therapeutic use Antifungal Agents - adverse effects Antifungal Agents - therapeutic use Candida - drug effects Candidiasis - drug therapy Candidiasis - physiopathology Catheterization Double-Blind Method Drug Therapy, Combination Female Fluconazole - adverse effects Fluconazole - therapeutic use Fungemia - drug therapy Fungemia - physiopathology Humans Male Middle Aged Neutropenia - etiology Treatment Outcome |
| Title | A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/12746765 https://www.proquest.com/docview/73305197 |
| Volume | 36 |
| WOSCitedRecordID | wos000182872200003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA6-EC--3685eC22adI2IIiK4kEXDwp7W9I8YGFt1-2uoP_Of-ZMdhcFEQ9eSktIE5hJMpP55hvGTrJEO1XGeSRjUUZCc4rvKhmJUiZGaJ0aHUhc7_JWq2i31cMMO5vmwhCscronho3a1obuyE9zdLwpyfK8_xJRzSiKrU4KaMyy-RQNGdLpvP0VQ0iKAGDEJZ1HmVTJt8pCxLki49-NynC43Kz8b1qrbHliVMLFWAvW2Iyr1tni_SRsvsE-LgCPJFs_d9-dBXyDskc0iRYCnpAAmm4AoYAH1B6IwjiydePAE6C90u91z0G_N2ogQLjKGgjMgZ8_2jUqR030zzgwXIJuYJzg9QZoHIOhHBqC4-swie6wAfMNzQ3YpyLgzWhIIYKqa6AZlXRR1Gyyp5vrx6vbaFK7ITKiUEP0b52SznLNdWKNyKXNCq_RdvCcOBAT5Y2wQnnnSyVTzW3Bc2sluvZFFlvj-BabwxHdDoMiFYYTq36Jzh_-UGn0qxMtU1_ExKWzy46noung2qCAh65cPWo6U-Hssu2xdDv9MYVHJ-FUZiWTe3_23WdLAb9HhK3ygM173BXcIVswr8NuMzgKKofP1sP9J23X5mo |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+randomized+and+blinded+multicenter+trial+of+high-dose+fluconazole+plus+placebo+versus+fluconazole+plus+amphotericin+B+as+therapy+for+candidemia+and+its+consequences+in+nonneutropenic+subjects&rft.jtitle=Clinical+infectious+diseases&rft.au=Rex%2C+John+H&rft.au=Pappas%2C+Peter+G&rft.au=Karchmer%2C+Adolf+W&rft.au=Sobel%2C+Jack&rft.date=2003-05-15&rft.eissn=1537-6591&rft.volume=36&rft.issue=10&rft.spage=1221&rft_id=info:doi/10.1086%2F374850&rft_id=info%3Apmid%2F12746765&rft_id=info%3Apmid%2F12746765&rft.externalDocID=12746765 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1537-6591&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1537-6591&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1537-6591&client=summon |