Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity

The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to antigens and commensals, and a tissue susceptible to one of the most prevalent human inflammatory diseases, periodontitis. To aid in understanding tissue-specific pathophysiology, we compile a single-cell tran...

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Veröffentlicht in:Cell Jg. 184; H. 15; S. 4090
Hauptverfasser: Williams, Drake Winslow, Greenwell-Wild, Teresa, Brenchley, Laurie, Dutzan, Nicolas, Overmiller, Andrew, Sawaya, Andrew Phillip, Webb, Simone, Martin, Daniel, Hajishengallis, George, Divaris, Kimon, Morasso, Maria, Haniffa, Muzlifah, Moutsopoulos, Niki Maria
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 22.07.2021
Schlagworte:
Adult
Epithelial Cells - cytology
Gene Expression Regulation
Genetic Predisposition to Disease
Gingiva - pathology
Humans
Immunity, Mucosal
Inflammation - immunology
Inflammation - pathology
Microbiota
Mouth Mucosa - cytology
Mouth Mucosa - immunology
Myeloid Cells - cytology
Neutrophils - cytology
Periodontitis - genetics
Periodontitis - immunology
Periodontitis - pathology
Single-Cell Analysis
Stromal Cells - cytology
T-Lymphocytes - cytology
stromal -immune interaction
oral mucosal immunity
human oral mucosal single-cell atlas
oral atlas
periodontitis single-cell atlas
mucosal immunity
ISSN:1097-4172, 1097-4172
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Beschreibung
Zusammenfassung:The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to antigens and commensals, and a tissue susceptible to one of the most prevalent human inflammatory diseases, periodontitis. To aid in understanding tissue-specific pathophysiology, we compile a single-cell transcriptome atlas of human oral mucosa in healthy individuals and patients with periodontitis. We uncover the complex cellular landscape of oral mucosal tissues and identify epithelial and stromal cell populations with inflammatory signatures that promote antimicrobial defenses and neutrophil recruitment. Our findings link exaggerated stromal cell responsiveness with enhanced neutrophil and leukocyte infiltration in periodontitis. Our work provides a resource characterizing the role of tissue stroma in regulating mucosal tissue homeostasis and disease pathogenesis.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2021.05.013