Inhibition of Apoptosis in Periodontitis
This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor...
Gespeichert in:
| Veröffentlicht in: | Journal of dental research Jg. 89; H. 1; S. 29 - 33 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Washington, DC
SAGE Publications
01.01.2010
International Association for Dental Research SAGE PUBLICATIONS, INC |
| Schlagworte: | |
| ISSN: | 0022-0345, 1544-0591, 1544-0591 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members. Gingival tissue samples were taken from healthy individuals and those with chronic periodontitis. The expression of TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, and survivin was determined immunohistologically and at the level of mRNA expression. Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues (p < 0.005). Statistically (p < 0.05) higher levels of cleaved caspase-3 and the cleaved caspase-3 inhibitors, xIAP and survivin, were seen. Similar changes were seen at the level of mRNA. The results indicate that apoptosis in periodontitis may be inhibited by elevated expression of TRAIL decoy receptors and cleaved caspase-3 inhibitors. |
|---|---|
| AbstractList | This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members. Gingival tissue samples were taken from healthy individuals and those with chronic periodontitis. The expression of TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, and survivin was determined immunohistologically and at the level of mRNA expression. Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues (p < 0.005). Statistically (p < 0.05) higher levels of cleaved caspase-3 and the cleaved caspase-3 inhibitors, xIAP and survivin, were seen. Similar changes were seen at the level of mRNA. The results indicate that apoptosis in periodontitis may be inhibited by elevated expression of TRAIL decoy receptors and cleaved caspase-3 inhibitors. This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members. Gingival tissue samples were taken from healthy individuals and those with chronic periodontitis. The expression of TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, and survivin was determined immunohistologically and at the level of mRNA expression. Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues (p < 0.005). Statistically (p < 0.05) higher levels of cleaved caspase-3 and the cleaved caspase-3 inhibitors, xIAP and survivin, were seen. Similar changes were seen at the level of mRNA. The results indicate that apoptosis in periodontitis may be inhibited by elevated expression of TRAIL decoy receptors and cleaved caspase-3 inhibitors.This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members. Gingival tissue samples were taken from healthy individuals and those with chronic periodontitis. The expression of TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, and survivin was determined immunohistologically and at the level of mRNA expression. Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues (p < 0.005). Statistically (p < 0.05) higher levels of cleaved caspase-3 and the cleaved caspase-3 inhibitors, xIAP and survivin, were seen. Similar changes were seen at the level of mRNA. The results indicate that apoptosis in periodontitis may be inhibited by elevated expression of TRAIL decoy receptors and cleaved caspase-3 inhibitors. This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members. Gingival tissue samples were taken from healthy individuals and those with chronic periodontitis. The expression of TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, and survivin was determined immunohistologically and at the level of mRNA expression. Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues ( p < 0.005). Statistically (p < 0.05) higher levels of cleaved caspase-3 and the cleaved caspase-3 inhibitors, xIAP and survivin, were seen. Similar changes were seen at the level of mRNA. The results indicate that apoptosis in periodontitis may be inhibited by elevated expression of TRAIL decoy receptors and cleaved caspase-3 inhibitors. [PUBLICATION ABSTRACT] |
| Author | DHARMAPATNI A. A. S. S. K. HOLDING C. A. HAYNES D. R. LUCAS H. BARTOLD P. M. |
| Author_xml | – sequence: 1 givenname: H. surname: Lucas fullname: Lucas, H. – sequence: 2 givenname: P.M. surname: Bartold fullname: Bartold, P.M. – sequence: 3 givenname: A.A.S.S.K. surname: Dharmapatni fullname: Dharmapatni, A.A.S.S.K. – sequence: 4 givenname: C.A. surname: Holding fullname: Holding, C.A. – sequence: 5 givenname: D.R. surname: Haynes fullname: Haynes, D.R. |
| BackLink | https://cir.nii.ac.jp/crid/1573950400963818752$$DView record in CiNii http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22327454$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19948942$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kbtvFDEQxi0URC6BngqdEAiahbFn_CqjiEekSFBAvfJ5bXC0Zx_2XsF_n13dQaQr0swU3--b5wU7yyUHxl5y-MC51h8BhAAkCRYlaDBP2IpLog6k5Wdstcjdop-zi9buALgVBp-xc24tGUtixd7f5N9pk6ZU8rrE9dWu7KbSUlunvP4eaipDydMst-fsaXRjCy-O-ZL9_Pzpx_XX7vbbl5vrq9vOkzFT57T2SoUwuGgVRQwClZISwSuHMpBHh8YbGzdkOHkVBXdWDmFQkUdyiJfs3aHurpY_-9CmfpuaD-Pocij71mskbqURNJOvT8i7sq95Hq4XYIk0cj5Dr47QfrMNQ7-raevq3_7fBWbg7RFwzbsxVpd9av85IVBokks3OHC-ltZqiA-loF-e0Z8-Y7aoE4tPk1tOPVWXxseM3cHY3K_wsNUj_JsDn1OaeyyRS41WAgFYhYYbLQXeA1TQn_U |
| CODEN | JDREAF |
| CitedBy_id | crossref_primary_10_1038_cddiscovery_2015_46 crossref_primary_10_1080_15321819_2010_538110 crossref_primary_10_1111_jre_12331 crossref_primary_10_1016_j_genrep_2021_101029 crossref_primary_10_1155_2013_503754 crossref_primary_10_1902_jop_2014_130718 crossref_primary_10_1111_prd_12369 crossref_primary_10_1016_j_taap_2022_116089 crossref_primary_10_1111_jre_13106 crossref_primary_10_1111_jre_12852 crossref_primary_10_1210_en_2012_1928 crossref_primary_10_3390_bioengineering10101193 crossref_primary_10_1007_s10616_024_00688_1 crossref_primary_10_1007_s10753_023_01851_0 crossref_primary_10_1016_j_bone_2014_10_016 crossref_primary_10_1016_j_jobcr_2023_05_010 crossref_primary_10_1007_s11418_012_0714_3 crossref_primary_10_1111_prd_12005 crossref_primary_10_3389_fcimb_2022_953277 crossref_primary_10_1007_s00784_021_03950_4 crossref_primary_10_1038_s41420_020_00356_1 crossref_primary_10_1038_s41598_019_39721_1 crossref_primary_10_1080_21505594_2024_2427234 crossref_primary_10_1177_0022034511403744 crossref_primary_10_7759_cureus_70858 crossref_primary_10_1002_JPER_17_0716 crossref_primary_10_3389_fimmu_2017_01017 crossref_primary_10_1111_odi_13032 crossref_primary_10_3109_00016357_2012_757638 crossref_primary_10_1002_JPER_21_0423 crossref_primary_10_1007_s40496_014_0015_x crossref_primary_10_1016_j_disamonth_2022_101348 crossref_primary_10_1111_ggi_12062 crossref_primary_10_1111_jre_12268 crossref_primary_10_1111_jre_12303 crossref_primary_10_3389_fimmu_2023_1164667 crossref_primary_10_1016_j_archoralbio_2024_105964 crossref_primary_10_3390_jcm12041701 crossref_primary_10_4103_ijdr_ijdr_62_23 crossref_primary_10_1111_j_1600_051X_2010_01672_x crossref_primary_10_1186_s13104_025_07274_4 crossref_primary_10_3390_ijms22020591 crossref_primary_10_1371_journal_pone_0168268 crossref_primary_10_1080_20002297_2021_2015130 crossref_primary_10_1016_j_jep_2024_117738 crossref_primary_10_1111_prd_12095 |
| Cites_doi | 10.1128/iai.63.6.2147-2153.1995 10.1002/jlb.54.4.283 10.1038/cr.2007.52 10.1034/j.1600-051x.2001.028009840.x 10.1111/j.1600-0765.1997.tb00568.x 10.1128/IAI.67.3.1450-1454.1999 10.1016/1074-7613(95)90057-8 10.1177/154405910708600913 10.1023/A:1011379307472 10.1136/ard.61.12.1047 10.3892/ijo.16.6.1137 10.1034/j.1600-0765.2003.00615.x 10.1016/S0014-5793(00)02324-3 10.1002/jcp.20067 10.1128/IAI.71.12.7232-7235.2003 10.1074/jbc.C400236200 10.1034/j.1600-051x.2000.027001041.x 10.1002/art.1780381012 10.1902/jop.1999.70.4.457 10.1126/science.277.5327.815 10.1076/ocii.10.1.47.10331 10.1126/science.277.5327.818 10.1016/S0083-6729(04)67023-3 10.1177/154405910308200202 10.1016/S0960-9822(06)00422-2 10.1101/gad.13.3.239 |
| ContentType | Journal Article |
| Copyright | 2010 International & American Associations for Dental Research 2015 INIST-CNRS SAGE Publications © Jan 2010 |
| Copyright_xml | – notice: 2010 International & American Associations for Dental Research – notice: 2015 INIST-CNRS – notice: SAGE Publications © Jan 2010 |
| DBID | RYH AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7RQ 7RV 7X7 7XB 88E 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. KB0 LK8 M0S M1P M7P NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U S0X U9A 7X8 |
| DOI | 10.1177/0022034509350708 |
| DatabaseName | CiNii Complete CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Career & Technical Education Database Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic SIRS Editorial MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Career and Technical Education (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Career and Technical Education ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic ProQuest Central Student CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Dentistry |
| EISSN | 1544-0591 |
| EndPage | 33 |
| ExternalDocumentID | 1998591541 19948942 22327454 10_1177_0022034509350708 10.1177_0022034509350708 10027307818 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .2E .2J .2N 01A 0R~ 18M 1~K 29K 2WC 31R 31U 31X 31Z 34H 4.4 53G 54M 5GY 5RE 5VS 7RQ 7RV 7X7 88E 8AO 8FE 8FH 8FI 8FJ 8FW 8R4 8R5 AABOD AACMV AACTG AAEWN AAGLT AAGMC AAJPV AAKGS AAPEO AAQXI AARDL AARDX AARIX AATAA AATBZ AAUAS AAWTL ABAWP ABCCA ABIDT ABJZC ABLUO ABPNF ABQKF ABQXT ABRHV ABUJY ABUWG ABVFX ACARO ACDXX ACFEJ ACGFO ACGFS ACGZU ACJER ACJTF ACLFY ACLZU ACOXC ACPRK ACROE ACSIQ ACUAV ACUIR ACXKE ACXMB ADBBV ADDLC ADEBD ADRRZ ADVBO AECGH AEDTQ AEILP AEKYL AENEX AEPTA AERKM AESZF AEUHG AEWDL AEWHI AFKRA AFKRG AFMOU AFOSN AFQAA AFUIA AGHKR AGKLV AGNHF AGPXR AGWFA AHDMH AHMBA AJGYC AJUZI AJXAJ ALIPV ALKWR ALMA_UNASSIGNED_HOLDINGS AMCVQ ANDLU ARTOV AUTPY AUVAJ AYAKG B3H B8R B8Z B94 BBNVY BBRGL BDDNI BENPR BHPHI BKEYQ BKIIM BKSCU BPACV BPHCQ BSEHC BVXVI BWJAD BYIEH CAG CCPQU COF D-I DB0 DF0 DO- DU5 DV7 DWQXO E3Z EBD EBS EJD EX3 F5P FHBDP FYUFA GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION GX1 H13 HCIFZ HMCUK HZ~ J8X K.F LK8 M1P M7P N9A NAPCQ O9- P.B P2P PHGZM PHGZT PQQKQ PROAC PSQYO Q1R Q2X Q7L Q7U Q83 ROL RYH S01 S0X SAUOL SCNPE SFC SGO SGR SGV SGZ SHG SPQ SPV TDR UKHRP W8F WOQ WOW ZONMY ZPPRI ZRKOI ZSSAH -TM .55 AABMB AADUE AAGGD AAITX AANSI AAOVH AAQXH AAXOT AAZBJ ABCJG ABDWY ABEIX ABFWQ ABHKI ABKRH ABPGX ABYTW ACDSZ ACFMA ACGBL ACLHI ACOFE ACSVP ADEIA ADMPF ADNON ADSTG ADTBJ ADUKL ADZZY AEQLS AEXFG AEXNY AFEET AFFNX AFGYO AHJOV AI. AIGRN AJEFB AJMMQ B8M CBRKF CDWPY CFDXU CORYS CQQTX CUTAK DC- DOPDO HF~ OHT P.9 SASJQ VH1 X7M ZE2 ZGI AAEJI AAPII AAYXX ABUAX AFFHD AJHME AJVBE CITATION PJZUB PPXIY PQGLB IQODW 3V. ACSBE ACTQU AEUIJ AIOMO ALTZF CGR CUY CVF ECM EIF M4V NPM PKN 7XB 8FK AZQEC GNUQQ K9. PKEHL PQEST PQUKI PRINS Q9U U9A 7X8 PUEGO |
| ID | FETCH-LOGICAL-c488t-a77c66eedaf964f3e23665530c6a35e4c3a38c89fb4814c6f21a95ded6f1f4a33 |
| IEDL.DBID | 7RQ |
| ISICitedReferencesCount | 46 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000272612000004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0022-0345 1544-0591 |
| IngestDate | Sat Sep 27 18:26:00 EDT 2025 Tue Oct 07 05:14:28 EDT 2025 Wed Feb 19 01:48:41 EST 2025 Mon Jul 21 09:18:43 EDT 2025 Sat Nov 29 05:18:03 EST 2025 Tue Nov 18 21:16:22 EST 2025 Tue Jun 17 22:29:50 EDT 2025 Fri Jun 27 00:19:15 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | survivin apoptosis TRAIL xIAP caspase-3 Human Immunohistochemistry Pathophysiology Stomatology Survivin X linked inhibitor of apoptosis protein Anatomic pathology Periodontal disease Periodontitis Apoptosis inhibitory protein TNF related apoptosis inducing ligand Inhibition Gingiva Apoptosis |
| Language | English |
| License | https://journals.sagepub.com/page/policies/text-and-data-mining-license CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c488t-a77c66eedaf964f3e23665530c6a35e4c3a38c89fb4814c6f21a95ded6f1f4a33 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 19948942 |
| PQID | 209447311 |
| PQPubID | 47467 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_734195824 proquest_journals_209447311 pubmed_primary_19948942 pascalfrancis_primary_22327454 crossref_primary_10_1177_0022034509350708 crossref_citationtrail_10_1177_0022034509350708 sage_journals_10_1177_0022034509350708 nii_cinii_1573950400963818752 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-01-01 |
| PublicationDateYYYYMMDD | 2010-01-01 |
| PublicationDate_xml | – month: 01 year: 2010 text: 2010-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Washington, DC |
| PublicationPlace_xml | – name: Washington, DC – name: United States – name: Alexandria |
| PublicationTitle | Journal of dental research |
| PublicationTitleAlternate | J Dent Res |
| PublicationTitle_FL | J Dent Res |
| PublicationYear | 2010 |
| Publisher | SAGE Publications International Association for Dental Research SAGE PUBLICATIONS, INC |
| Publisher_xml | – name: SAGE Publications – name: International Association for Dental Research – name: SAGE PUBLICATIONS, INC |
| References | ALIKHANI-ETAL-2004 TAK-ETAL-1995 ISHIHARA-ETAL-1997 CROTTI-ETAL-2003 KIM-AND-GUPTA-2000 BICKEL-ETAL-2001 DEVERAUX-AND-REED-1999 WASSENAAR-ETAL-1995 MORI-ETAL-2007 CROTTI-ETAL-2002 XU-AND-SHI-2007 MURRAY-AND-WILTON-2003 HOLCIK-ETAL-2001 YAMAMOTO-ETAL-1996 SHERIDAN-ETAL-1997 AKGUL-ETAL-2001 MARSTERS-ETAL-1997 YANG-ETAL-2002 PAN-ETAL-1997 VAN-DYKE-AND-SERHAN-2003 LEE-ETAL-1993 RASMUSSEN-ETAL-2000 SCHENKEIN-1999 DOHI-ETAL-2004 AGGARWAL-ETAL-2004 WILEY-ETAL-1995 SAWA-ETAL-1999 LI-AND-AMAR-2007 MANGAN-ETAL-1993 |
| References_xml | – ident: MORI-ETAL-2007 – ident: YAMAMOTO-ETAL-1996 – ident: WASSENAAR-ETAL-1995 doi: 10.1128/iai.63.6.2147-2153.1995 – ident: LEE-ETAL-1993 doi: 10.1002/jlb.54.4.283 – ident: XU-AND-SHI-2007 doi: 10.1038/cr.2007.52 – ident: BICKEL-ETAL-2001 doi: 10.1034/j.1600-051x.2001.028009840.x – ident: ISHIHARA-ETAL-1997 doi: 10.1111/j.1600-0765.1997.tb00568.x – ident: SAWA-ETAL-1999 doi: 10.1128/IAI.67.3.1450-1454.1999 – ident: WILEY-ETAL-1995 doi: 10.1016/1074-7613(95)90057-8 – ident: LI-AND-AMAR-2007 doi: 10.1177/154405910708600913 – ident: HOLCIK-ETAL-2001 doi: 10.1023/A:1011379307472 – ident: CROTTI-ETAL-2002 doi: 10.1136/ard.61.12.1047 – ident: KIM-AND-GUPTA-2000 doi: 10.3892/ijo.16.6.1137 – ident: CROTTI-ETAL-2003 doi: 10.1034/j.1600-0765.2003.00615.x – ident: AKGUL-ETAL-2001 doi: 10.1016/S0014-5793(00)02324-3 – ident: ALIKHANI-ETAL-2004 doi: 10.1002/jcp.20067 – ident: MURRAY-AND-WILTON-2003 doi: 10.1128/IAI.71.12.7232-7235.2003 – ident: DOHI-ETAL-2004 doi: 10.1074/jbc.C400236200 – ident: RASMUSSEN-ETAL-2000 doi: 10.1034/j.1600-051x.2000.027001041.x – ident: TAK-ETAL-1995 doi: 10.1002/art.1780381012 – ident: SCHENKEIN-1999 doi: 10.1902/jop.1999.70.4.457 – ident: MANGAN-ETAL-1993 – ident: PAN-ETAL-1997 doi: 10.1126/science.277.5327.815 – ident: YANG-ETAL-2002 doi: 10.1076/ocii.10.1.47.10331 – ident: SHERIDAN-ETAL-1997 doi: 10.1126/science.277.5327.818 – ident: AGGARWAL-ETAL-2004 doi: 10.1016/S0083-6729(04)67023-3 – ident: VAN-DYKE-AND-SERHAN-2003 doi: 10.1177/154405910308200202 – ident: MARSTERS-ETAL-1997 doi: 10.1016/S0960-9822(06)00422-2 – ident: DEVERAUX-AND-REED-1999 doi: 10.1101/gad.13.3.239 |
| SSID | ssj0019283 |
| Score | 2.1662824 |
| Snippet | This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor... |
| SourceID | proquest pubmed pascalfrancis crossref sage nii |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 29 |
| SubjectTerms | Adult apoptosis Apoptosis - physiology Biological and medical sciences Case-Control Studies Caspase 3 - genetics Caspase 3 - metabolism caspase-3 Chronic Periodontitis - immunology Chronic Periodontitis - metabolism Chronic Periodontitis - pathology Facial bones, jaws, teeth, parodontium: diseases, semeiology Gingiva - cytology Gingiva - immunology Humans Immunohistochemistry In Situ Nick-End Labeling Inhibitor of Apoptosis Proteins Leukocytes - metabolism Medical sciences Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Reference Values RNA, Messenger - analysis survivin TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism TRAIL Tumor Necrosis Factor Decoy Receptors - genetics Tumor Necrosis Factor Decoy Receptors - metabolism X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism xIAP |
| Title | Inhibition of Apoptosis in Periodontitis |
| URI | https://cir.nii.ac.jp/crid/1573950400963818752 https://journals.sagepub.com/doi/full/10.1177/0022034509350708 https://www.ncbi.nlm.nih.gov/pubmed/19948942 https://www.proquest.com/docview/209447311 https://www.proquest.com/docview/734195824 |
| Volume | 89 |
| WOSCitedRecordID | wos000272612000004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1544-0591 dateEnd: 20101031 omitProxy: false ssIdentifier: ssj0019283 issn: 0022-0345 databaseCode: M7P dateStart: 19960201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Career & Technical Education Database customDbUrl: eissn: 1544-0591 dateEnd: 20101031 omitProxy: false ssIdentifier: ssj0019283 issn: 0022-0345 databaseCode: 7RQ dateStart: 19960201 isFulltext: true titleUrlDefault: https://search.proquest.com/career providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1544-0591 dateEnd: 20101031 omitProxy: false ssIdentifier: ssj0019283 issn: 0022-0345 databaseCode: 7X7 dateStart: 19960201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1544-0591 dateEnd: 20101031 omitProxy: false ssIdentifier: ssj0019283 issn: 0022-0345 databaseCode: 7RV dateStart: 19960201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1544-0591 dateEnd: 20101031 omitProxy: false ssIdentifier: ssj0019283 issn: 0022-0345 databaseCode: BENPR dateStart: 19960201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RFgkulDdL6SoHhOAQ0cQTP05VW1qBhFZLBWhvkePYaiSULM2W389Mks1qEfTCxYc8JrZnPOPxfJkBeB1kWXjFwlsWGGMpQmxM4eLggy8zg8EWXXb9z2o204uFmQ_YnHaAVa51Yqeoy8bxGTk56QZRiSQ5Xv6MuWgUB1eHCho7sEd2WrKYq8svYxDBpH0WTgasHwnMNlFK_gk85UscBiSh11tWaaeuKsZI2pamKfT1Lf62Ad0Cf3X26GL_P0fyEB4MG9HopJecR3DH14_h3gcGD3H9tyfw9lN9VRUdoitqQnSybJarpq3aqKqjOckt-bNdPtb2KXy7OP969jEe6irEjpbrKrZKOSnJONpgJAbhUyEllw9y0orMoxNWaKdNKFAn6GRIE2uy0pcyJAGtEM9gt25q_wKiI1t4bVOLPhhUBWsDFSQ5eQ5FKHU6gffrec3dkHSca1_8yJN1nvE_ODGBd-Mbyz7hxi3PHhKriDC3ScYxR9ZJrFMS8sPo69MtJo4EaU9E3niGEzhYsygf1m6bj_yZQDTepUXHkRRb--amzRVnwct0SgSe97Kw6asxqA3St9-wcGzI_msQL2_twwHc7_EKfOjzCnZX1zf-EO66X8Te62kn7137nduF6lo9hb3T89n8cspI1vlvmT0DsQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgtReeFOW0pIDIDhENLbjxwGhilJ11WXVQ5H2FhzHFpFQsjRbED-K_8hMsslqEfTWA5cc8nCczOfPM57xDMDzIIvcKwJvkYtYFDzExuQuDj74IjUi2LzNrj9R06mezczZBvzq98JQWGXPiS1RF7WjNXI00o0QiifJu_m3mIpGkXO1r6DRoeLU__yBFlvzdnyE4n3B2PGH8_cn8bKoQOwQq4vYKuWkxJnBBiNF4J5xKal2jpOWp144brl22oRc6EQ4GVhiTVr4QoYkCEvrn8j4N5HGFdl6ajbYd6grdVk_KUD-gIt05RWlTeeMTpHbEQeZXpsFb1RlSTGZtkGxhK6ext8U3rVgs3b-O77zn_25u3B7qWhHh93IuAcbvroPW0cUHEX17R7Aq3H1pczbiLWoDtHhvJ4v6qZsorKKznBcor3e5pttHsKna-noI9is6so_hujA5l5bZoUPRqic2E4FiUasEzwUmo3gTS_HzC2TqlNtj69Z0udR_0PyI3g9PDHvEopcce8eQgMbpmOSkk-VOJc4M0E7E9--vwaaoUHU-ZgSqRjBbg-JbMlNTTbgYQTRcBVJhTxFtvL1ZZMpyvKXaoYN7HTYW_XVGKGNwHe_JDCumv3XRzy5sg_PYOvk_OMkm4ynp7uw3cVm0ALXU9hcXFz6PbjlvqOoL_bbsRbB5-uG6G9d11w4 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9RADLbKFgEX3o-ltOQACA5Rm8lkHgeECtsVq1arFQKptzCZzIhIKFmaLYifxr_Dzmu1CHrrgUsOeTiT-LPHHntsgGde5JmTBN484yHPYx9qndnQO-_yRHNvsqa6_omcz9XpqV5swa9-LwylVfY6sVHUeWVpjRyddM25jKNo33dZEYvJ9M3yW0gNpCjQ2nfTaBFy7H7-QO-tfj2bIKufMzY9-vjufdg1GAgt4nYVGimtEDhLGK8F97FjsRDUR8cKEyeO29jEyirtM64iboVnkdFJ7nLhI88NrYWi9t-WaGPwEWy_PZovPgwhDM3aGqCULn8Q82QdI6Ut6IxOURASRU5tzIlXyqKgDE1TI5N8213jb-bvRupZMxtOb_3H__E23OxM8OCwlZk7sOXKu3B9QmlT1PnuHryclV-KrMllCyofHC6r5aqqizooymCBEouefFOJtr4Pny5loA9gVFalewTBgcmcMsxw5zWXGelB6QW6t5bHPldsDPs9T1PblVunrh9f06ivsP4HCsbwanhi2ZYaueDeXYQJEqZjlFC0lbQxadMIPVB8-94GgAaCaA0yyRM-hp0eHmmntep0wMYYguEqqhuKIZnSVed1Kqn-X6IYEnjY4nA9Vq250hzf_YKAuSb7r494fOEYnsI1RGZ6Mpsf78CNNmmDVr6ewGh1du524ar9jpw-2-sEL4DPl43R32abZlg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Inhibition+of+Apoptosis+in+Periodontitis&rft.jtitle=Journal+of+dental+research&rft.au=Lucas%2C+H&rft.au=Bartold%2C+PM&rft.au=Dharmapatni%2C+AASSK&rft.au=Holding%2C+CA&rft.date=2010-01-01&rft.pub=SAGE+PUBLICATIONS%2C+INC&rft.issn=0022-0345&rft.eissn=1544-0591&rft.volume=89&rft.issue=1&rft.spage=29&rft_id=info:doi/10.1177%2F0022034509350708&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=1998591541 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-0345&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-0345&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-0345&client=summon |