Inhibition of Apoptosis in Periodontitis

This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor...

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Vydáno v:	Journal of dental research Ročník 89; číslo 1; s. 29 - 33
Hlavní autoři:	Lucas, H., Bartold, P.M., Dharmapatni, A.A.S.S.K., Holding, C.A., Haynes, D.R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Washington, DC SAGE Publications 01.01.2010 International Association for Dental Research SAGE PUBLICATIONS, INC
Témata:	Adult apoptosis Apoptosis - physiology Biological and medical sciences Case-Control Studies Caspase 3 - genetics Caspase 3 - metabolism caspase-3 Chronic Periodontitis - immunology Chronic Periodontitis - metabolism Chronic Periodontitis - pathology Facial bones, jaws, teeth, parodontium: diseases, semeiology Gingiva - cytology Gingiva - immunology Humans Immunohistochemistry In Situ Nick-End Labeling Inhibitor of Apoptosis Proteins Leukocytes - metabolism Medical sciences Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Reference Values RNA, Messenger - analysis survivin TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism TRAIL Tumor Necrosis Factor Decoy Receptors - genetics Tumor Necrosis Factor Decoy Receptors - metabolism X-Linked Inhibitor of Apoptosis Protein - genetics X-Linked Inhibitor of Apoptosis Protein - metabolism xIAP survivin apoptosis TRAIL xIAP caspase-3 Human Immunohistochemistry Pathophysiology Stomatology Survivin X linked inhibitor of apoptosis protein Anatomic pathology Periodontal disease Periodontitis Apoptosis inhibitory protein TNF related apoptosis inducing ligand Inhibition Gingiva Apoptosis
ISSN:	0022-0345, 1544-0591, 1544-0591
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Popis
Shrnutí:	This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members. Gingival tissue samples were taken from healthy individuals and those with chronic periodontitis. The expression of TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, and survivin was determined immunohistologically and at the level of mRNA expression. Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues (p < 0.005). Statistically (p < 0.05) higher levels of cleaved caspase-3 and the cleaved caspase-3 inhibitors, xIAP and survivin, were seen. Similar changes were seen at the level of mRNA. The results indicate that apoptosis in periodontitis may be inhibited by elevated expression of TRAIL decoy receptors and cleaved caspase-3 inhibitors.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0022-0345 1544-0591 1544-0591
DOI:	10.1177/0022034509350708