COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent immune cells is not complete. We applied single-cell RNA sequencing to 284 samples from 196 COVID-19 patients and controls...

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Veröffentlicht in:	Cell Jg. 184; H. 7; S. 1895
Hauptverfasser:	Ren, Xianwen, Wen, Wen, Fan, Xiaoying, Hou, Wenhong, Su, Bin, Cai, Pengfei, Li, Jiesheng, Liu, Yang, Tang, Fei, Zhang, Fan, Yang, Yu, He, Jiangping, Ma, Wenji, He, Jingjing, Wang, Pingping, Cao, Qiqi, Chen, Fangjin, Chen, Yuqing, Cheng, Xuelian, Deng, Guohong, Deng, Xilong, Ding, Wenyu, Feng, Yingmei, Gan, Rui, Guo, Chuang, Guo, Weiqiang, He, Shuai, Jiang, Chen, Liang, Juanran, Li, Yi-Min, Lin, Jun, Ling, Yun, Liu, Haofei, Liu, Jianwei, Liu, Nianping, Liu, Shu-Qiang, Luo, Meng, Ma, Qiang, Song, Qibing, Sun, Wujianan, Wang, GaoXiang, Wang, Feng, Wang, Ying, Wen, Xiaofeng, Wu, Qian, Xu, Gang, Xie, Xiaowei, Xiong, Xinxin, Xing, Xudong, Xu, Hao, Yin, Chonghai, Yu, Dongdong, Yu, Kezhuo, Yuan, Jin, Zhang, Biao, Zhang, Peipei, Zhang, Tong, Zhao, Jincun, Zhao, Peidong, Zhou, Jianfeng, Zhou, Wei, Zhong, Sujuan, Zhong, Xiaosong, Zhang, Shuye, Zhu, Lin, Zhu, Ping, Zou, Bin, Zou, Jiahua, Zuo, Zengtao, Bai, Fan, Huang, Xi, Zhou, Penghui, Jiang, Qinghua, Huang, Zhiwei, Bei, Jin-Xin, Wei, Lai, Bian, Xiu-Wu, Liu, Xindong, Cheng, Tao, Li, Xiangpan, Zhao, Pingsen, Wang, Fu-Sheng, Wang, Hongyang, Su, Bing, Zhang, Zheng, Qu, Kun, Wang, Xiaoqun, Chen, Jiekai, Jin, Ronghua, Zhang, Zemin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2021
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Child China Cohort Studies COVID-19 - immunology Cytokines - metabolism Female Humans Male Megakaryocytes - immunology Middle Aged Monocytes - immunology RNA, Viral - blood RNA, Viral - isolation & purification SARS-CoV-2 - genetics Single-Cell Analysis Transcriptome - immunology Young Adult China COVID-19 SARS-CoV-2 single-cell transcriptomics cytokine storm host cell range B cell receptor sequencing cell-cell interaction single-cell RNA-seq ligand-receptor interaction T cell receptor sequencing
ISSN:	1097-4172, 1097-4172
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