Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage

Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxi...

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Vydané v:Foods Ročník 9; číslo 6; s. 804
Hlavní autori: Taamalli, Amani, Feriani, Anouar, Lozano-Sanchez, Jesús, Ghazouani, Lakhdar, El Mufti, Afoua, Allagui, Mohamed Salah, Segura-Carretero, Antonio, Mhamdi, Ridha, Arráez-Roman, David
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Basel MDPI AG 18.06.2020
MDPI
Predmet:
albino
Animal models
antioxidants
Biochemical markers
Biochemistry
blood
By products
Carbon dioxide
Carbon tetrachloride
Damage
DNA damage
Fibrosis
Food science
Free radicals
hepatoprotective effect
Hepatotoxicity
histopathology
Laboratory animals
Leaves
Lipids
Liver
liver cirrhosis
olive leaves
Olive oil
olives
Oxidative stress
Parameters
Plant extracts
Polyphenols
rats
supercritical fluid extraction
Supercritical gas extraction
virgin olive oil
Tunisia
ISSN:2304-8158, 2304-8158
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Abstract Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl4) in rat models. For this purpose, healthy albino rats of 180–250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl4 treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO2 extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl4 treatment.
AbstractList Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO₂) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl₄) in rat models. For this purpose, healthy albino rats of 180–250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl₄ treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO₂ extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl₄ treatment.
Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl4) in rat models. For this purpose, healthy albino rats of 180–250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl4 treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO2 extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl4 treatment.
Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl4) in rat models. For this purpose, healthy albino rats of 180-250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl4 treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO2 extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl4 treatment.Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl4) in rat models. For this purpose, healthy albino rats of 180-250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl4 treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO2 extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl4 treatment.
Author Lozano-Sanchez, Jesús
Arráez-Roman, David
Segura-Carretero, Antonio
El Mufti, Afoua
Taamalli, Amani
Ghazouani, Lakhdar
Feriani, Anouar
Allagui, Mohamed Salah
Mhamdi, Ridha
AuthorAffiliation 1 Department of Chemistry, College of Sciences, University of Hafr Al Batin, P.O. Box 1803, Hafr Al Batin 39524, Saudi Arabia; ataamalli@uhb.edu.sa
2 Laboratoire de Biotechnologie de l’Olivier, Centre de Biotechnologie de Borj-Cedria, B.P.901, Hammam-Lif 2050, Tunisia; ridha.mhamdi@cbbc.rnrt.tn
5 Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain
6 Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax 3018, Tunisia; amsallagui@yahoo.fr
3 Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia; ferianianwer@yahoo.fr (A.F.); ghazouani2005@yahoo.fr (L.G.); mufti.afoua-90@hotmail.com (A.E.M.)
4 Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, Edificio BioRegión, 18016 Granada, Spain; ansegura@ugr.es (A.S.-C.); darraez@ugr.es (D.A.-R.)
AuthorAffiliation_xml – name: 3 Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa 2112, Tunisia; ferianianwer@yahoo.fr (A.F.); ghazouani2005@yahoo.fr (L.G.); mufti.afoua-90@hotmail.com (A.E.M.)
– name: 5 Department of Analytical Chemistry, Faculty of Sciences, University of Granada, 18071 Granada, Spain
– name: 6 Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax 3018, Tunisia; amsallagui@yahoo.fr
– name: 4 Research and Development Functional Food Centre (CIDAF), Health Science Technological Park, Avenida del Conocimiento 37, Edificio BioRegión, 18016 Granada, Spain; ansegura@ugr.es (A.S.-C.); darraez@ugr.es (D.A.-R.)
– name: 1 Department of Chemistry, College of Sciences, University of Hafr Al Batin, P.O. Box 1803, Hafr Al Batin 39524, Saudi Arabia; ataamalli@uhb.edu.sa
– name: 2 Laboratoire de Biotechnologie de l’Olivier, Centre de Biotechnologie de Borj-Cedria, B.P.901, Hammam-Lif 2050, Tunisia; ridha.mhamdi@cbbc.rnrt.tn
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Snippet Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major...
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StartPage 804
SubjectTerms albino
Animal models
antioxidants
Biochemical markers
Biochemistry
blood
By products
Carbon dioxide
Carbon tetrachloride
Damage
DNA damage
Fibrosis
Food science
Free radicals
hepatoprotective effect
Hepatotoxicity
histopathology
Laboratory animals
Leaves
Lipids
Liver
liver cirrhosis
olive leaves
Olive oil
olives
Oxidative stress
Parameters
Plant extracts
Polyphenols
rats
supercritical fluid extraction
Supercritical gas extraction
virgin olive oil
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Title Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage
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