Potential Hepatoprotective Activity of Super Critical Carbon Dioxide Olive Leaf Extracts against CCl4-Induced Liver Damage

Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxi...

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Veröffentlicht in:Foods Jg. 9; H. 6; S. 804
Hauptverfasser: Taamalli, Amani, Feriani, Anouar, Lozano-Sanchez, Jesús, Ghazouani, Lakhdar, El Mufti, Afoua, Allagui, Mohamed Salah, Segura-Carretero, Antonio, Mhamdi, Ridha, Arráez-Roman, David
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 18.06.2020
MDPI
Schlagworte:
albino
Animal models
antioxidants
Biochemical markers
Biochemistry
blood
By products
Carbon dioxide
Carbon tetrachloride
Damage
DNA damage
Fibrosis
Food science
Free radicals
hepatoprotective effect
Hepatotoxicity
histopathology
Laboratory animals
Leaves
Lipids
Liver
liver cirrhosis
olive leaves
Olive oil
olives
Oxidative stress
Parameters
Plant extracts
Polyphenols
rats
supercritical fluid extraction
Supercritical gas extraction
virgin olive oil
Tunisia
ISSN:2304-8158, 2304-8158
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Zusammenfassung:Virgin olive oil has demonstrated its effective activity against oxidative stress. However, data on the bioactive effect of olive leaves or their major constituents on the liver are scarce. The present research work was conducted to evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracts from fresh and dried olive leaves on hepatotoxicity caused by carbon tetrachloride (CCl4) in rat models. For this purpose, healthy albino rats of 180–250 g weight were used. The assessment of biochemical markers was carried out on blood and liver tissue. Then, a histopathological study was carried out on liver tissue. The obtained results showed that fresh and dried olive leaf extracts ameliorate the perturbed biochemical parameters caused by CCl4 treatment. Furthermore, the results registered for the histopathological study are in accordance with the biochemical parameters and the protective capacity of SC-CO2 extracts against DNA damage, indicating that olive leaf extracts helped to improve liver fibrosis caused by CCl4 treatment.
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ISSN:2304-8158
2304-8158
DOI:10.3390/foods9060804