Sclerostin's role in bone–muscle crosstalk and osteoporosis pathogenesis

This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological...

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Bibliographic Details
Published in:Osteoporosis and Sarcopenia Vol. 11; no. 3; pp. 69 - 82
Main Authors: Shahid, Hamzah, Morya, Vivek Kumar, Noh, Kyu-Cheol
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.09.2025
Elsevier
대한골다공증학회
Subjects:
Crosstalk
Endocrinology and Metabolism
Molecular interaction
Myokines
Osteoporosis
Regulators
Sclerostin
정형외과학
Myokines
Osteoporosis
Sclerostin
Molecular interaction
Regulators
Crosstalk
ISSN:2405-5255, 2405-5263, 2405-5263
Online Access:Get full text
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Summary:This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological and pathological conditions. Recent advances underscore sclerostin's role in osteoporosis pathogenesis and its involvement in bone remodeling, while also revealing its emerging significance in muscle–bone communication. Despite these insights, the underlying mechanisms of its regulation remain incompletely understood. By consolidating recent research, this review provides a comprehensive perspective on sclerostin's multifaceted roles and their implications for bone and muscle health.
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ISSN:2405-5255
2405-5263
2405-5263
DOI:10.1016/j.afos.2025.06.004