Heme oxygenase-2/adiponectin protein–protein interaction in metabolic syndrome

► HO-2 knockout mice present a metabolic syndrome-like phenotype. ► Inhibition of both HO-1 and HO-2 decreased adiponectin formation. ► Existence of protein–protein interaction between adiponectin and HO-2. ► HO-2 acts as a molecular chaperone. ► Increasing information on protein–protein complexes w...

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Veröffentlicht in:	Biochemical and biophysical research communications Jg. 432; H. 4; S. 606 - 611
Hauptverfasser:	Vanella, Luca, Li Volti, Giovanni, Guccione, Salvatore, Rappazzo, Giancarlo, Salvo, Eliana, Pappalardo, Morena, Forte, Stefano, Schwartzman, Michal L., Abraham, Nader G.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 22.03.2013
Schlagworte:	adipocytes adipogenesis Adiponectin Adiponectin - genetics Adiponectin - metabolism adipose tissue Animals anti-inflammatory activity culture media heme Heme oxygenase heme oxygenase (biliverdin-producing) Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism insulin resistance lipid content Membrane Proteins - genetics Membrane Proteins - metabolism Metabolic syndrome Metabolic Syndrome - metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains molecular chaperones obesity Protein interactions protein-protein interactions RNA, Small Interfering - genetics secretion small interfering RNA stem cells subcutaneous fat Two-Hybrid System Techniques MSCs HO ROS Heme oxygenase CoPP Metabolic syndrome Protein interactions Adiponectin
ISSN:	0006-291X, 1090-2104, 1090-2104
Online-Zugang:	Volltext
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