Calcineurin inhibitors augment endothelial-to-mesenchymal transition by enhancing proliferation in association with cytokine-mediated activation

Calcineurin Inhibitors (CNIs) are routinely used for immunosuppression following solid organ transplantation. However, the prolonged use of these agents lead to organ fibrosis which limits their efficacy. CNIs induce TGFβ expression, which is reported to augment endothelial-to-mesenchymal transition...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 519; no. 4; pp. 667 - 673
Main Authors:	Woda, Craig B., Bruneau, Sarah, Mak, Anne Linde, Haskova, Zdenka, Liu, Kaifeng, Ghosh, Chandra C., Briscoe, David M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 19.11.2019
Subjects:	actin Animals cadherins Cadherins - metabolism Calcineurin inhibitors Calcineurin Inhibitors - pharmacology Cell Proliferation - drug effects Cells, Cultured CHO Cells Chronic allograft rejection Cricetinae Cricetulus cyclosporine Cyclosporine - pharmacology Endothelial cells Endothelial-to-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects fibrosis Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - physiology Humans hypoxia immunosuppression inflammation muscles organ transplantation Signal Transduction - drug effects Tacrolimus - pharmacology Transplantation Tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology Endothelial-to-mesenchymal transition Transplantation Chronic allograft rejection Tumor necrosis factor Endothelial cells Calcineurin inhibitors
ISSN:	0006-291X, 1090-2104, 1090-2104
Online Access:	Get full text
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