In Vivo Cellular Reprogramming: The Next Generation

Cellular reprogramming technology has created new opportunities in understanding human disease, drug discovery, and regenerative medicine. While a combinatorial code was initially found to reprogram somatic cells to pluripotency, a "second generation" of cellular reprogramming involves lin...

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Vydané v:Cell Ročník 166; číslo 6; s. 1386
Hlavní autori: Srivastava, Deepak, DeWitt, Natalie
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 08.09.2016
Predmet:
Cellular Reprogramming
Humans
Induced Pluripotent Stem Cells - cytology
Insulin-Secreting Cells - cytology
Myocytes, Cardiac - cytology
Neurons - cytology
Regenerative Medicine - trends
Research - trends
Translational Medical Research - standards
Translational Medical Research - trends
ISSN:1097-4172, 1097-4172
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Popis
Shrnutí:Cellular reprogramming technology has created new opportunities in understanding human disease, drug discovery, and regenerative medicine. While a combinatorial code was initially found to reprogram somatic cells to pluripotency, a "second generation" of cellular reprogramming involves lineage-restricted transcription factors and microRNAs that directly reprogram one somatic cell to another. This technology was enabled by gene networks active during development, which induce global shifts in the epigenetic landscape driving cell fate decisions. A major utility of direct reprogramming is the potential of harnessing resident support cells within damaged organs to regenerate lost tissue by converting them into the desired cell type in situ. Here, we review the progress in direct cellular reprogramming, with a focus on the paradigm of in vivo reprogramming for regenerative medicine, while pointing to hurdles that must be overcome to translate this technology into future therapeutics.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2016.08.055