Cholinergic modulation of preattentive auditory processing in aging

Auditory event-related potential (ERP) components P50 and N100 are thought to index preattentive auditory processing underlying stimulus detection, whereas a subsequent component termed mismatch negativity (MMN) has been proposed to reflect comparison of incoming stimuli to a short-lived sensory mem...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Vol. 27; no. 2; pp. 387 - 392
Main Authors: Pekkonen, Eero, Jääskeläinen, Iiro P., Kaakkola, Seppo, Ahveninen, Jyrki
Format: Journal Article
Language:English
Published: United States Elsevier Inc 15.08.2005
Elsevier Limited
Subjects:
Acetylcholine
Age
Aged
Aged, 80 and over
Aging
Aging - psychology
Alzheimer's disease
Anesthesia
Attention - drug effects
Attention - physiology
Auditory Perception - drug effects
Auditory Perception - physiology
Brain
Cognitive ability
Double-Blind Method
Electroencephalography
Electroencephalography (EEG)
Event-related potentials
Evoked Potentials, Auditory - drug effects
Evoked Potentials, Auditory - physiology
Female
Functional Laterality - physiology
Glycopyrrolate - pharmacology
Humans
Magnetoencephalography
Magnetoencephalography (MEG)
Male
Memory
Middle Aged
Mismatch negativity
Neuropsychological Tests
Parasympathetic Nervous System - drug effects
Parasympathetic Nervous System - physiology
Parasympatholytics - pharmacology
Scopolamine
Scopolamine Hydrobromide - pharmacology
Studies
Magnetoencephalography (MEG)
Scopolamine
Mismatch negativity
Electroencephalography (EEG)
Aging
Event-related potentials
Acetylcholine
Alzheimer's disease
ISSN:1053-8119, 1095-9572
Online Access:Get full text
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Summary:Auditory event-related potential (ERP) components P50 and N100 are thought to index preattentive auditory processing underlying stimulus detection, whereas a subsequent component termed mismatch negativity (MMN) has been proposed to reflect comparison of incoming stimuli to a short-lived sensory memory trace of preceding sounds. Existing evidence suggests impairment of preattentive auditory processing in aging, which appears to be accompanied by decline of cholinergic activity. Previous studies indicate that scopolamine, which is a centrally acting muscarinic receptor antagonist, modulates preattentive auditory processing in young subjects. It has remained elusive, however, to which extent scopolamine affects preattentive auditory processing in aged subjects. We measured auditory responses simultaneously with electroencephalogram (EEG) and magnetoencephalogram (MEG) from nine non-demented elderly subjects after intravenous injection of scopolamine or glycopyrrolate, the latter being a peripherally acting cholinergic antagonist, using a double blind protocol. Scopolamine significantly delayed electric P50, both electric and magnetic N100 responses, whereas subsequent MMN and P200 responses were not altered by scopolamine. Our results indicate that the cholinergic system modulates auditory processing underlying stimulus detection in aging. In addition, auditory evoked responses appear to have different age-related sensitivity to cholinergic modulation. The combined MEG/EEG measurements using particularly auditory N100 response might offer an objective tool to monitor cholinergic activity in aging and Alzheimer's disease (AD).
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ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2005.04.018