Inflammasome Complexes: Emerging Mechanisms and Effector Functions

Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new...

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Bibliographic Details
Published in:Cell Vol. 165; no. 4; p. 792
Main Authors: Rathinam, Vijay A K, Fitzgerald, Katherine A
Format: Journal Article
Language:English
Published: United States 05.05.2016
Subjects:
Animals
Cell Death
Humans
Inflammasomes - immunology
Inflammasomes - physiology
Inflammation - immunology
Inflammation - metabolism
Signal Transduction
ISSN:1097-4172, 1097-4172
Online Access:Get more information
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Summary:Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic cell death in response to pathogens and endogenous danger signals. Recent discoveries, however, are beginning to unveil new components of the inflammasome machinery as well as the full spectrum of inflammasome functions, extending their influence beyond canonical functions to regulation of eicosanoid storm, autophagy, and metabolism. In addition, the receptor components of the inflammasome can also regulate diverse biological processes, such as cellular proliferation, gene transcription, and tumorigenesis, all of which are independent of their inflammasome complex-forming capabilities. Here, we review these recent advances that are shaping our understanding of the complex biology of the inflammasome and its constituents.
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2016.03.046