The COX-1/COX-2 balance in asthma

Prostanoids are important signalling molecules which are produced locally both physiologically and in inflammatory diseases and have potent effects on a number of inflammatory processes. Prostanoids have often been the forgotten mediators of airway inflammation in the lung mainly because aspirin, an...

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Vydané v:	Clinical and experimental allergy Ročník 28; číslo 9; s. 1050 - 1058
Hlavní autori:	PANG, L, PITT, A, PETKOVA, D, KNOX, A. J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford BSL Blackwell Science Ltd 01.09.1998 Blackwell Wiley Subscription Services, Inc
Predmet:	Asthma - enzymology Biological and medical sciences Chronic obstructive pulmonary disease, asthma Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Humans Isoenzymes - metabolism Lung - drug effects Lung - enzymology Medical sciences Membrane Proteins Pneumology Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - pharmacology Human Prostaglandin-endoperoxide synthase Prostaglandin Respiratory disease Enzyme Isozyme Inflammation Review Asthma Respiratory tract Lung function Prostanoid Obstructive pulmonary disease Oxidoreductases
ISSN:	0954-7894, 1365-2222
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Popis
Shrnutí:	Prostanoids are important signalling molecules which are produced locally both physiologically and in inflammatory diseases and have potent effects on a number of inflammatory processes. Prostanoids have often been the forgotten mediators of airway inflammation in the lung mainly because aspirin, an inhibitor of prostaglandin synthesis which has been used in medicine for almost a century, has little effect on airway function when given orally to the majority of asthmatics. Recent research in several areas has renewed interest in the role of prostanoids in airways inflammation. These have included studies showing that exogenously applied PGE sub(2) potently protects against several bronchoconstrictor challenges, studies showing that COX-2 the inducible form of cyclo-oxygenase is upregulated by the proinflammatory cytokines and mediators present in asthmatic airways and studies showing that inhaled cyclo-oxygenase inhibitors have protective effects on induced bronchoconstriction in asthma. The role of cyclo-oxygenase products in regulating airway function and the COX balance in asthma will be reviewed here.
Bibliografia:	ark:/67375/WNG-WMLG49CR-V ArticleID:CEA311 istex:64A48D53A0927CD9742DC7131846DC05A8EC2BAE ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-2
ISSN:	0954-7894 1365-2222
DOI:	10.1046/j.1365-2222.1998.00311.x