T-Cell Response to Viral Hemorrhagic Fevers

Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and o...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Vaccines (Basel) Ročník 7; číslo 1; s. 11
Hlavní autoři:	Perdomo-Celis, Federico, Salvato, Maria S., Medina-Moreno, Sandra, Zapata, Juan C.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 22.01.2019 MDPI
Témata:	Dengue fever dengue virus Dizziness Ebola virus Fatalities Fever hantavirus Hemorrhage Immune response Immune response (cell-mediated) Infectious diseases interferon-gamma Lassa virus Lymphocytes T Muscles Muscular fatigue Pathogenesis Review RNA viruses Signs and symptoms T-cells tumor necrosis factor-alpha vaccine viral hemorrhagic fever Viruses yellow fever virus Brazil United States > US West Africa Africa Ebola virus T-cells tumor necrosis factor-alpha vaccine yellow fever virus hantavirus dengue virus viral hemorrhagic fever Lassa virus interferon-gamma
ISSN:	2076-393X, 2076-393X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	2076-393X 2076-393X
DOI:	10.3390/vaccines7010011