Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublinea...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 377; no. 6608; p. 890
Main Authors:	Bowen, John E, Addetia, Amin, Dang, Ha V, Stewart, Cameron, Brown, Jack T, Sharkey, William K, Sprouse, Kaitlin R, Walls, Alexandra C, Mazzitelli, Ignacio G, Logue, Jennifer K, Franko, Nicholas M, Czudnochowski, Nadine, Powell, Abigail E, Dellota, Jr, Exequiel, Ahmed, Kumail, Ansari, Asefa Shariq, Cameroni, Elisabetta, Gori, Andrea, Bandera, Alessandra, Posavad, Christine M, Dan, Jennifer M, Zhang, Zeli, Weiskopf, Daniela, Sette, Alessandro, Crotty, Shane, Iqbal, Najeeha Talat, Corti, Davide, Geffner, Jorge, Snell, Gyorgy, Grifantini, Renata, Chu, Helen Y, Veesler, David
Format:	Journal Article
Language:	English
Published:	United States 19.08.2022
Subjects:	Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology COVID-19 - blood COVID-19 - prevention & control COVID-19 Vaccines - immunology Humans Immunization, Secondary SARS-CoV-2 - immunology Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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Summary:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicron-induced severe disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1095-9203 1095-9203
DOI:	10.1126/science.abq0203