HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by the activation of inflammatory caspases, which leads to the proteolytic maturation of interleukin 1β (IL-1β) and pyroptosis. Here, we show that nucleotide-binding domain, leucine-rich repea...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 369; H. 6510
Hauptverfasser:	Magupalli, Venkat Giri, Negro, Roberto, Tian, Yuzi, Hauenstein, Arthur V, Di Caprio, Giuseppe, Skillern, Wesley, Deng, Qiufang, Orning, Pontus, Alam, Hasan B, Maliga, Zoltan, Sharif, Humayun, Hu, Jun Jacob, Evavold, Charles L, Kagan, Jonathan C, Schmidt, Florian I, Fitzgerald, Katherine A, Kirchhausen, Tom, Li, Yongqing, Wu, Hao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.09.2020
Schlagworte:	Animals DNA-Binding Proteins - metabolism HEK293 Cells Histone Deacetylase 6 - genetics Histone Deacetylase 6 - metabolism Humans Immunologic Surveillance Inflammasomes - immunology Inflammasomes - metabolism Lipopolysaccharides - immunology Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Microtubule-Organizing Center - metabolism Microtubules - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Protein Transport Pyrin - metabolism
ISSN:	1095-9203, 1095-9203
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