HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by the activation of inflammatory caspases, which leads to the proteolytic maturation of interleukin 1β (IL-1β) and pyroptosis. Here, we show that nucleotide-binding domain, leucine-rich repea...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 369; číslo 6510
Hlavní autoři:	Magupalli, Venkat Giri, Negro, Roberto, Tian, Yuzi, Hauenstein, Arthur V, Di Caprio, Giuseppe, Skillern, Wesley, Deng, Qiufang, Orning, Pontus, Alam, Hasan B, Maliga, Zoltan, Sharif, Humayun, Hu, Jun Jacob, Evavold, Charles L, Kagan, Jonathan C, Schmidt, Florian I, Fitzgerald, Katherine A, Kirchhausen, Tom, Li, Yongqing, Wu, Hao
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 18.09.2020
Témata:	Animals DNA-Binding Proteins - metabolism HEK293 Cells Histone Deacetylase 6 - genetics Histone Deacetylase 6 - metabolism Humans Immunologic Surveillance Inflammasomes - immunology Inflammasomes - metabolism Lipopolysaccharides - immunology Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Microtubule-Organizing Center - metabolism Microtubules - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Protein Transport Pyrin - metabolism
ISSN:	1095-9203, 1095-9203
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