Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs exhibited differences in their protein homeostasis network. Whereas activated NSCs had active proteasomes, quiesce...

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Vydané v:	Science (American Association for the Advancement of Science) Ročník 359; číslo 6381; s. 1277
Hlavní autori:	Leeman, Dena S, Hebestreit, Katja, Ruetz, Tyson, Webb, Ashley E, McKay, Andrew, Pollina, Elizabeth A, Dulken, Ben W, Zhao, Xiaoai, Yeo, Robin W, Ho, Theodore T, Mahmoudi, Salah, Devarajan, Keerthana, Passegué, Emmanuelle, Rando, Thomas A, Frydman, Judith, Brunet, Anne
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 16.03.2018
Predmet:	Aging - physiology Animals Cell Division Cellular Senescence Lysosomes - physiology Mice Mice, Inbred C57BL Neural Stem Cells - physiology
ISSN:	1095-9203, 1095-9203
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