Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

Some pathogens and pests deliver small RNAs (sRNAs) into host cells to suppress host immunity. Conversely, hosts also transfer sRNAs into pathogens and pests to inhibit their virulence. Although sRNA trafficking has been observed in a wide variety of interactions, how sRNAs are transferred, especial...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 360; no. 6393; p. 1126
Main Authors: Cai, Qiang, Qiao, Lulu, Wang, Ming, He, Baoye, Lin, Feng-Mao, Palmquist, Jared, Huang, Sienna-Da, Jin, Hailing
Format: Journal Article
Language:English
Published: United States 08.06.2018
Subjects:
Arabidopsis - immunology
Arabidopsis - microbiology
Botrytis - genetics
Botrytis - pathogenicity
Extracellular Vesicles - metabolism
Host-Pathogen Interactions
Plant Diseases - immunology
Plant Diseases - microbiology
Plant Immunity
RNA Interference
RNA, Plant - metabolism
RNA, Small Interfering - metabolism
Virulence - genetics
Virulence Factors - genetics
ISSN:1095-9203, 1095-9203
Online Access:Get more information
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Summary:Some pathogens and pests deliver small RNAs (sRNAs) into host cells to suppress host immunity. Conversely, hosts also transfer sRNAs into pathogens and pests to inhibit their virulence. Although sRNA trafficking has been observed in a wide variety of interactions, how sRNAs are transferred, especially from hosts to pathogens and pests, is still unknown. Here, we show that host cells secrete exosome-like extracellular vesicles to deliver sRNAs into fungal pathogen These sRNA-containing vesicles accumulate at the infection sites and are taken up by the fungal cells. Transferred host sRNAs induce silencing of fungal genes critical for pathogenicity. Thus, has adapted exosome-mediated cross-kingdom RNA interference as part of its immune responses during the evolutionary arms race with the pathogen.
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.aar4142