Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

Understanding gene function and regulation in homeostasis and disease requires knowledge of the cellular and tissue contexts in which genes are expressed. Here, we applied four single-nucleus RNA sequencing methods to eight diverse, archived, frozen tissue types from 16 donors and 25 samples, genera...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 376; H. 6594; S. eabl4290
Hauptverfasser:	Eraslan, Gökcen, Drokhlyansky, Eugene, Anand, Shankara, Fiskin, Evgenij, Subramanian, Ayshwarya, Slyper, Michal, Wang, Jiali, Van Wittenberghe, Nicholas, Rouhana, John M, Waldman, Julia, Ashenberg, Orr, Lek, Monkol, Dionne, Danielle, Win, Thet Su, Cuoco, Michael S, Kuksenko, Olena, Tsankov, Alexander M, Branton, Philip A, Marshall, Jamie L, Greka, Anna, Getz, Gad, Segrè, Ayellet V, Aguet, François, Rozenblatt-Rosen, Orit, Ardlie, Kristin G, Regev, Aviv
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 13.05.2022
Schlagworte:	Biomarkers Cell Nucleus - genetics Disease - genetics Genome-Wide Association Study Humans Organ Specificity Phenotype RNA-Seq - methods
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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