Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

Understanding gene function and regulation in homeostasis and disease requires knowledge of the cellular and tissue contexts in which genes are expressed. Here, we applied four single-nucleus RNA sequencing methods to eight diverse, archived, frozen tissue types from 16 donors and 25 samples, genera...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) Vol. 376; no. 6594; p. eabl4290
Main Authors:	Eraslan, Gökcen, Drokhlyansky, Eugene, Anand, Shankara, Fiskin, Evgenij, Subramanian, Ayshwarya, Slyper, Michal, Wang, Jiali, Van Wittenberghe, Nicholas, Rouhana, John M, Waldman, Julia, Ashenberg, Orr, Lek, Monkol, Dionne, Danielle, Win, Thet Su, Cuoco, Michael S, Kuksenko, Olena, Tsankov, Alexander M, Branton, Philip A, Marshall, Jamie L, Greka, Anna, Getz, Gad, Segrè, Ayellet V, Aguet, François, Rozenblatt-Rosen, Orit, Ardlie, Kristin G, Regev, Aviv
Format:	Journal Article
Language:	English
Published:	United States 13.05.2022
Subjects:	Biomarkers Cell Nucleus - genetics Disease - genetics Genome-Wide Association Study Humans Organ Specificity Phenotype RNA-Seq - methods
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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