Adults with celiac disease exhibit overexpression of endogenous retroviruses, TRIM28, and SETDB1 despite gluten-free diet

•Celiac disease is immune-mediated and triggered by gluten in predisposed people.•HERVs are viral DNA remnants linked to immune and inflammatory disorders.•The study analyzed HERVs, TRIM28, SETDB1 in 51 celiac adults on gluten-free diet.•CeD patients showed higher HERV and gene expression vs. health...

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Veröffentlicht in:	Virus research Jg. 359; S. 199613
Hauptverfasser:	Tovo, Pier-Angelo, Armandi, Angelo, Bruno, Mauro, Caviglia, Gian Paolo, Montanari, Paola, Pitoni, Demis, Calvi, Cristina, Frara, Simone, Dileo, Eleonora, Gambarino, Stefano, Galliano, Ilaria, Ribaldone, Davide Giuseppe, Bergallo, Massimiliano
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.09.2025 Elsevier
Schlagworte:	Adult Celiac disease Celiac Disease - diet therapy Celiac Disease - genetics Celiac Disease - virology Diet, Gluten-Free Endogenous Retroviruses - genetics epigenetics Female GFD Histone-Lysine N-Methyltransferase - genetics Human endogenous retroviruses Humans Male Middle Aged Prospective Studies SETDB1 TRIM28 Tripartite Motif-Containing Protein 28 - blood Tripartite Motif-Containing Protein 28 - genetics Young Adult Celiac disease Human endogenous retroviruses TRIM28 SETDB1 GFD epigenetics
ISSN:	0168-1702, 1872-7492, 1872-7492
Online-Zugang:	Volltext
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