Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder

Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor β (TGF-β) between patients with major depressive disorder and healthy controls. Blood samples were collected from 41 pati...

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Veröffentlicht in:Basic and clinical neuroscience Jg. 7; H. 2; S. 137 - 142
Hauptverfasser: Davami, M., Baharlou, R., Ahmadi Vasmehjani, A., Ghanizadeh, A., Keshtkar, M., Dezhkam, I., Atashzar, M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Iran Negah Scientific Publisher 01.04.2016
Iranian Neuroscience Society
Iran University of Medical Sciences
Schlagworte:
Autoimmune diseases
Enzyme-linked immunosorbent assay
Immune system
Inflammatory response
Interleukin 17
Interleukin 21
Major depressive disorder
Mental depression
Research Papers
Serum levels
Transforming growth factor-b
Transforming growth factor-beta
Inflammatory response
Transforming growth factor-beta
Interleukin-17
interleukin-21
Major depressive disorder
ISSN:2228-7442, 2008-126X, 2228-7442
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Zusammenfassung:Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor β (TGF-β) between patients with major depressive disorder and healthy controls. Blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. The subjects were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum concentrations of IL-21, IL-17, and TGF-β were assessed using ELISA. The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-β level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs. 174.8±27.20 pg/mL, (P<0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15 pg/mL (P>0.05). Considering pro-inflammatory cytokines, current results support the association of inflammatory response and depressive disorder. So, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts.
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ISSN:2228-7442
2008-126X
2228-7442
DOI:10.15412/J.BCN.03070207