Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies

To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by beta-amyloid (Aβ). Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA...

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Vydáno v:Basic and clinical neuroscience Ročník 7; číslo 2; s. 97 - 106
Hlavní autoři: Hajipour, S., Sarkaki, A., Farbood, Y., Eidi, A., Mortazavi, P., Valizadeh, Z.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Iran Negah Scientific Publisher 01.04.2016
Iranian Neuroscience Society
Iran University of Medical Sciences
Témata:
Alzheimer disease
Alzheimer's disease
Beta-amyloid
Brain injury
Cognitive ability
Dementia
Dementia disorders
Dentate gyrus
Free radicals
Gallic acid
Hippocampus
Long-term potentiation
Neurodegenerative diseases
Neuronal apoptosis
Oligomerization
Rat
Research Papers
Rodents
Neuronal apoptosis
Rat
Alzheimer disease
Long-term potentiation
Beta-amyloid
ISSN:2228-7442, 2008-126X, 2228-7442
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Shrnutí:To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by beta-amyloid (Aβ). Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Aβ (1μg/μL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP). Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P<0.001), while significantly improved in AD rats treated with GA (P<0.05, P<0.01). Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Aβ but with no effect on healthy rats.
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ISSN:2228-7442
2008-126X
2228-7442
DOI:10.15412/J.BCN.03070203