Embryo-scale, single-cell spatial transcriptomics

Spatial patterns of gene expression manifest at scales ranging from local (e.g., cell-cell interactions) to global (e.g., body axis patterning). However, current spatial transcriptomics methods either average local contexts or are restricted to limited fields of view. Here, we introduce sci-Space, w...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Science (American Association for the Advancement of Science) Ročník 373; číslo 6550; s. 111
Hlavní autori: Srivatsan, Sanjay R, Regier, Mary C, Barkan, Eliza, Franks, Jennifer M, Packer, Jonathan S, Grosjean, Parker, Duran, Madeleine, Saxton, Sarah, Ladd, Jon J, Spielmann, Malte, Lois, Carlos, Lampe, Paul D, Shendure, Jay, Stevens, Kelly R, Trapnell, Cole
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 02.07.2021
Predmet:
Animals
Atlases as Topic
Body Patterning - genetics
Brain - embryology
Cell Movement
Embryo, Mammalian - embryology
Embryonic Development - genetics
Gene Expression Profiling - methods
Mice
Neurogenesis - genetics
Neurons - cytology
Single-Cell Analysis - methods
Transcriptome
ISSN:1095-9203, 1095-9203
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Abstract Spatial patterns of gene expression manifest at scales ranging from local (e.g., cell-cell interactions) to global (e.g., body axis patterning). However, current spatial transcriptomics methods either average local contexts or are restricted to limited fields of view. Here, we introduce sci-Space, which retains single-cell resolution while resolving spatial heterogeneity at larger scales. Applying sci-Space to developing mouse embryos, we captured approximate spatial coordinates and whole transcriptomes of about 120,000 nuclei. We identify thousands of genes exhibiting anatomically patterned expression, leverage spatial information to annotate cellular subtypes, show that cell types vary substantially in their extent of spatial patterning, and reveal correlations between pseudotime and the migratory patterns of differentiating neurons. Looking forward, we anticipate that sci-Space will facilitate the construction of spatially resolved single-cell atlases of mammalian development.
AbstractList Spatial patterns of gene expression manifest at scales ranging from local (e.g., cell-cell interactions) to global (e.g., body axis patterning). However, current spatial transcriptomics methods either average local contexts or are restricted to limited fields of view. Here, we introduce sci-Space, which retains single-cell resolution while resolving spatial heterogeneity at larger scales. Applying sci-Space to developing mouse embryos, we captured approximate spatial coordinates and whole transcriptomes of about 120,000 nuclei. We identify thousands of genes exhibiting anatomically patterned expression, leverage spatial information to annotate cellular subtypes, show that cell types vary substantially in their extent of spatial patterning, and reveal correlations between pseudotime and the migratory patterns of differentiating neurons. Looking forward, we anticipate that sci-Space will facilitate the construction of spatially resolved single-cell atlases of mammalian development.Spatial patterns of gene expression manifest at scales ranging from local (e.g., cell-cell interactions) to global (e.g., body axis patterning). However, current spatial transcriptomics methods either average local contexts or are restricted to limited fields of view. Here, we introduce sci-Space, which retains single-cell resolution while resolving spatial heterogeneity at larger scales. Applying sci-Space to developing mouse embryos, we captured approximate spatial coordinates and whole transcriptomes of about 120,000 nuclei. We identify thousands of genes exhibiting anatomically patterned expression, leverage spatial information to annotate cellular subtypes, show that cell types vary substantially in their extent of spatial patterning, and reveal correlations between pseudotime and the migratory patterns of differentiating neurons. Looking forward, we anticipate that sci-Space will facilitate the construction of spatially resolved single-cell atlases of mammalian development.
Spatial patterns of gene expression manifest at scales ranging from local (e.g., cell-cell interactions) to global (e.g., body axis patterning). However, current spatial transcriptomics methods either average local contexts or are restricted to limited fields of view. Here, we introduce sci-Space, which retains single-cell resolution while resolving spatial heterogeneity at larger scales. Applying sci-Space to developing mouse embryos, we captured approximate spatial coordinates and whole transcriptomes of about 120,000 nuclei. We identify thousands of genes exhibiting anatomically patterned expression, leverage spatial information to annotate cellular subtypes, show that cell types vary substantially in their extent of spatial patterning, and reveal correlations between pseudotime and the migratory patterns of differentiating neurons. Looking forward, we anticipate that sci-Space will facilitate the construction of spatially resolved single-cell atlases of mammalian development.
Author Franks, Jennifer M
Duran, Madeleine
Shendure, Jay
Stevens, Kelly R
Barkan, Eliza
Packer, Jonathan S
Lampe, Paul D
Saxton, Sarah
Regier, Mary C
Ladd, Jon J
Spielmann, Malte
Srivatsan, Sanjay R
Grosjean, Parker
Lois, Carlos
Trapnell, Cole
Author_xml – sequence: 1
  givenname: Sanjay R
  orcidid: 0000-0001-7282-0487
  surname: Srivatsan
  fullname: Srivatsan, Sanjay R
  organization: Department of Genome Sciences, University of Washington, Seattle, WA, USA
– sequence: 2
  givenname: Mary C
  orcidid: 0000-0001-9074-6604
  surname: Regier
  fullname: Regier, Mary C
  organization: Institute for Stem Cell and Regenerative Medicine, Seattle, WA, USA
– sequence: 3
  givenname: Eliza
  orcidid: 0000-0001-7871-4327
  surname: Barkan
  fullname: Barkan, Eliza
  organization: Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA
– sequence: 4
  givenname: Jennifer M
  orcidid: 0000-0003-2400-5431
  surname: Franks
  fullname: Franks, Jennifer M
  organization: Department of Genome Sciences, University of Washington, Seattle, WA, USA
– sequence: 5
  givenname: Jonathan S
  orcidid: 0000-0003-4025-0007
  surname: Packer
  fullname: Packer, Jonathan S
  organization: Foresite Labs, Boston, MA, USA
– sequence: 6
  givenname: Parker
  orcidid: 0000-0002-2024-119X
  surname: Grosjean
  fullname: Grosjean, Parker
  organization: Department of Bioengineering. University of Washington, Seattle, WA, USA
– sequence: 7
  givenname: Madeleine
  orcidid: 0000-0003-1648-2369
  surname: Duran
  fullname: Duran, Madeleine
  organization: Department of Genome Sciences, University of Washington, Seattle, WA, USA
– sequence: 8
  givenname: Sarah
  orcidid: 0000-0002-3901-4843
  surname: Saxton
  fullname: Saxton, Sarah
  organization: Department of Bioengineering. University of Washington, Seattle, WA, USA
– sequence: 9
  givenname: Jon J
  surname: Ladd
  fullname: Ladd, Jon J
  organization: Translational Research Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
– sequence: 10
  givenname: Malte
  orcidid: 0000-0002-0583-4683
  surname: Spielmann
  fullname: Spielmann, Malte
  organization: Human Molecular Genomics Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
– sequence: 11
  givenname: Carlos
  orcidid: 0000-0002-7305-2317
  surname: Lois
  fullname: Lois, Carlos
  organization: Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA
– sequence: 12
  givenname: Paul D
  orcidid: 0000-0002-1399-2761
  surname: Lampe
  fullname: Lampe, Paul D
  organization: Translational Research Program, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
– sequence: 13
  givenname: Jay
  orcidid: 0000-0002-1516-1865
  surname: Shendure
  fullname: Shendure, Jay
  email: shendure@uw.edu, ksteve@uw.edu, coletrap@uw.edu
  organization: Brotman Baty Institute for Precision Medicine, Seattle, WA, USA
– sequence: 14
  givenname: Kelly R
  orcidid: 0000-0002-4024-2990
  surname: Stevens
  fullname: Stevens, Kelly R
  email: shendure@uw.edu, ksteve@uw.edu, coletrap@uw.edu
  organization: Department of Laboratory Medicine and Pathology, Seattle, WA, USA
– sequence: 15
  givenname: Cole
  orcidid: 0000-0002-8105-4347
  surname: Trapnell
  fullname: Trapnell, Cole
  email: shendure@uw.edu, ksteve@uw.edu, coletrap@uw.edu
  organization: Brotman Baty Institute for Precision Medicine, Seattle, WA, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34210887$$D View this record in MEDLINE/PubMed
BookMark eNpNj8tLxDAYxIOsuA89e5MePZg1j6ZtjrKsD1jwsvfyJf0qkTStSXvY_96KK3iaGfgxzKzJIvQBCbnlbMu5KB6TdRgsbsEYrWRxQVacaUW1YHLxzy_JOqVPxuas5RVZylxwVlXlivB9Z-Kpp8mCx4csufDhkVr0PksDjA58NkYIyUY3jH3nbLomly34hDdn3ZDj8_64e6WH95e33dOB2rwqRypaNCKXzbwKmtIwKZDbgtvWSFNWqjW5siUDAw0oUAwEliAb3WpmTKNRbMj9b-0Q-68J01h3Lv3sgoD9lGqh8ipnVcH4jN6d0cl02NRDdB3EU_33UnwDlpFX0w
CitedBy_id crossref_primary_10_1109_ACCESS_2024_3479153
crossref_primary_10_1016_j_impact_2025_100565
crossref_primary_10_1038_s41593_022_01030_8
crossref_primary_10_1093_nargab_lqae100
crossref_primary_10_1111_cgf_14575
crossref_primary_10_3389_fcell_2024_1386739
crossref_primary_10_3390_ijms24032943
crossref_primary_10_1038_s41556_024_01435_6
crossref_primary_10_1007_s12551_024_01179_5
crossref_primary_10_1007_s42977_022_00136_1
crossref_primary_10_1016_j_semcdb_2025_01_002
crossref_primary_10_1186_s13059_023_03138_x
crossref_primary_10_1002_mco2_70328
crossref_primary_10_1016_j_molcel_2021_12_012
crossref_primary_10_1136_jmedgenet_2022_108588
crossref_primary_10_1089_cbr_2023_0116
crossref_primary_10_1126_science_abg7216
crossref_primary_10_1093_bioinformatics_btaf131
crossref_primary_10_1016_j_neuron_2023_01_016
crossref_primary_10_1186_s40779_024_00526_7
crossref_primary_10_1016_j_celrep_2023_112412
crossref_primary_10_1038_s41575_024_00915_2
crossref_primary_10_3389_fncir_2021_788560
crossref_primary_10_1038_s41580_024_00768_2
crossref_primary_10_1016_j_jdsr_2023_10_006
crossref_primary_10_1126_science_abm5874
crossref_primary_10_1016_j_cell_2022_04_003
crossref_primary_10_1242_dev_200180
crossref_primary_10_1038_s41467_023_43220_3
crossref_primary_10_1002_qub2_70006
crossref_primary_10_1038_s41587_024_02173_8
crossref_primary_10_3389_fneur_2024_1400469
crossref_primary_10_1016_j_csbj_2022_05_025
crossref_primary_10_1186_s40779_024_00537_4
crossref_primary_10_1002_advs_202305449
crossref_primary_10_1038_s41592_023_01992_y
crossref_primary_10_1038_s41467_023_42237_y
crossref_primary_10_1038_s41593_022_01196_1
crossref_primary_10_1186_s12859_024_05906_3
crossref_primary_10_1186_s12943_024_02040_9
crossref_primary_10_1016_j_csbj_2023_04_007
crossref_primary_10_1038_s41592_021_01272_7
crossref_primary_10_1093_nar_gkac889
crossref_primary_10_3390_jcdd9010001
crossref_primary_10_3390_cancers17071215
crossref_primary_10_3390_biom13010156
crossref_primary_10_3389_fimmu_2024_1499301
crossref_primary_10_1007_s12016_024_09001_6
crossref_primary_10_1093_bioadv_vbad181
crossref_primary_10_1016_j_devcel_2022_04_021
crossref_primary_10_1093_eurheartj_ehac095
crossref_primary_10_1016_j_tig_2022_03_016
crossref_primary_10_1111_evo_14420
crossref_primary_10_1016_j_cell_2023_11_016
crossref_primary_10_1002_adhm_202300903
crossref_primary_10_1038_s41588_025_02148_8
crossref_primary_10_1038_s41587_022_01272_8
crossref_primary_10_1016_j_cell_2024_05_055
crossref_primary_10_1681_ASN_0000000600
crossref_primary_10_1016_j_cell_2024_07_040
crossref_primary_10_2174_1574893618666230529145130
crossref_primary_10_1186_s13059_022_02824_6
crossref_primary_10_1242_dmm_049538
crossref_primary_10_1186_s12967_023_04150_2
crossref_primary_10_1186_s43556_023_00144_0
crossref_primary_10_3390_bios13070712
crossref_primary_10_1038_s44222_023_00084_y
crossref_primary_10_1186_s13059_023_02893_1
crossref_primary_10_3390_biom15081067
crossref_primary_10_1038_s41467_023_41666_z
crossref_primary_10_1093_jmicro_dfad059
crossref_primary_10_1002_j_2040_4603_2023_tb00266_x
crossref_primary_10_1101_gr_278001_123
crossref_primary_10_1002_jcb_30134
crossref_primary_10_1126_scitranslmed_adm6783
crossref_primary_10_1038_s41576_022_00515_3
crossref_primary_10_1002_advs_202206939
crossref_primary_10_1038_s41587_023_01716_9
crossref_primary_10_1038_s41467_022_34271_z
crossref_primary_10_1002_advs_202302558
crossref_primary_10_1101_gad_352277_124
crossref_primary_10_1016_j_heliyon_2025_e42668
crossref_primary_10_1038_s41584_023_01052_x
crossref_primary_10_1016_j_neuron_2023_02_028
crossref_primary_10_1016_j_cell_2022_06_049
crossref_primary_10_1186_s12864_023_09832_1
crossref_primary_10_1038_s42003_024_06694_5
crossref_primary_10_1038_s41592_022_01409_2
crossref_primary_10_1016_j_ijantimicag_2025_107494
crossref_primary_10_1016_j_semcancer_2023_06_006
crossref_primary_10_1038_s41698_025_01028_y
crossref_primary_10_1186_s13073_022_01075_1
crossref_primary_10_1038_s41467_023_40155_7
crossref_primary_10_1038_s41592_025_02771_7
crossref_primary_10_1038_s41581_024_00841_1
crossref_primary_10_1038_s41588_023_01435_6
crossref_primary_10_1002_pro_4458
crossref_primary_10_1093_humupd_dmad017
crossref_primary_10_1016_j_crmeth_2022_100369
crossref_primary_10_1016_j_jid_2024_09_006
crossref_primary_10_1016_j_trsl_2024_08_001
crossref_primary_10_1038_s41586_023_06548_w
crossref_primary_10_1371_journal_pcbi_1009991
crossref_primary_10_3390_biology13060451
crossref_primary_10_59717_j_xinn_life_2024_100097
crossref_primary_10_3389_fcell_2023_1142923
crossref_primary_10_1016_j_molcel_2024_08_002
crossref_primary_10_1515_medgen_2022_2156
crossref_primary_10_1016_j_kint_2022_06_011
crossref_primary_10_1038_s41467_023_43120_6
crossref_primary_10_1038_s41592_022_01604_1
crossref_primary_10_1016_j_jpha_2023_06_002
crossref_primary_10_1016_j_cels_2025_101266
crossref_primary_10_1038_s41586_023_06837_4
crossref_primary_10_3390_diagnostics13182963
crossref_primary_10_1016_j_jpha_2023_04_003
crossref_primary_10_3389_fphar_2021_775245
crossref_primary_10_1093_nar_gkac874
crossref_primary_10_1111_all_15781
crossref_primary_10_1038_s41592_023_01773_7
crossref_primary_10_1038_s41413_025_00429_w
crossref_primary_10_1016_j_jaci_2024_11_001
crossref_primary_10_1126_sciadv_adt7450
crossref_primary_10_12688_f1000research_122775_1
crossref_primary_10_1016_j_clim_2023_109634
crossref_primary_10_1016_j_stem_2022_04_012
crossref_primary_10_1016_j_jgg_2023_03_011
crossref_primary_10_1016_j_cell_2024_04_035
crossref_primary_10_1111_exd_14827
crossref_primary_10_1038_s41596_022_00752_0
crossref_primary_10_1002_smtd_202401171
crossref_primary_10_1038_s41392_022_00960_w
crossref_primary_10_1101_gr_280281_124
crossref_primary_10_3892_mmr_2024_13281
crossref_primary_10_1016_j_mam_2024_101276
crossref_primary_10_1093_nar_gkad933
crossref_primary_10_2217_fon_2022_0156
crossref_primary_10_3390_ijms23031748
crossref_primary_10_1016_j_ydbio_2022_03_002
crossref_primary_10_1146_annurev_biodatasci_040324_030052
crossref_primary_10_1002_ctm2_70331
crossref_primary_10_1126_science_adx3800
crossref_primary_10_3389_fgene_2025_1554773
crossref_primary_10_1002_mco2_765
crossref_primary_10_1186_s40779_023_00471_x
crossref_primary_10_1016_j_cej_2024_155937
crossref_primary_10_1111_cpr_13761
crossref_primary_10_3390_mi16040426
crossref_primary_10_1016_j_molcel_2023_06_018
crossref_primary_10_1007_s44272_024_00018_8
crossref_primary_10_1038_s41576_024_00750_w
crossref_primary_10_1093_nar_gkac219
crossref_primary_10_3389_fonc_2022_1019111
crossref_primary_10_1038_s41551_024_01236_0
crossref_primary_10_1186_s12943_024_02113_9
crossref_primary_10_1016_j_jgg_2025_09_003
crossref_primary_10_1016_j_tcb_2023_10_012
crossref_primary_10_1007_s12539_024_00603_4
crossref_primary_10_1038_s41467_023_37111_w
crossref_primary_10_1093_bfgp_elad036
crossref_primary_10_1002_smtd_202401107
crossref_primary_10_1016_j_cels_2023_08_005
crossref_primary_10_1016_j_cmpb_2024_108431
crossref_primary_10_1002_hep_32629
crossref_primary_10_1016_j_gpb_2022_06_006
ContentType Journal Article
Copyright Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Copyright_xml – notice: Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1126/science.abb9536
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Sciences (General)
Biology
EISSN 1095-9203
ExternalDocumentID 34210887
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIBIB NIH HHS
  grantid: T32 EB001650
– fundername: NHGRI NIH HHS
  grantid: UM1 HG011586
– fundername: NHLBI NIH HHS
  grantid: U54 HL145611
– fundername: NHGRI NIH HHS
  grantid: R01 HG010632
– fundername: NHLBI NIH HHS
  grantid: DP2 HL137188
GroupedDBID ---
--Z
-DZ
-ET
-~X
.-4
..I
.55
.DC
08G
0R~
0WA
123
18M
2FS
2KS
2WC
2XV
34G
36B
39C
3R3
53G
5RE
66.
6OB
6TJ
7X2
7~K
85S
8F7
AABCJ
AACGO
AAIKC
AAMNW
AANCE
AAWTO
ABCQX
ABDBF
ABDEX
ABDQB
ABEFU
ABIVO
ABJNI
ABOCM
ABPLY
ABPPZ
ABQIJ
ABTLG
ABWJO
ABZEH
ACBEA
ACBEC
ACGFO
ACGFS
ACGOD
ACIWK
ACMJI
ACNCT
ACPRK
ACQOY
ACUHS
ADDRP
ADUKH
ADXHL
AEGBM
AENEX
AETEA
AFBNE
AFFNX
AFHKK
AFQFN
AFRAH
AGNAY
AGSOS
AHMBA
AIDAL
AIDUJ
AJGZS
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALSLI
ASPBG
AVWKF
BKF
BLC
C45
CGR
CS3
CUY
CVF
DB2
DU5
EBS
ECM
EIF
EMOBN
F5P
FA8
FEDTE
HZ~
I.T
IAO
IEA
IGS
IH2
IHR
INH
INR
IOF
IOV
IPO
IPY
ISE
JCF
JLS
JSG
JST
K-O
KCC
L7B
LSO
LU7
M0P
MQT
MVM
N9A
NEJ
NHB
NPM
O9-
OCB
OFXIZ
OGEVE
OMK
OVD
P-O
P2P
PQQKQ
PZZ
RHI
RXW
SC5
SJN
TAE
TEORI
TN5
TWZ
UBW
UCV
UHB
UKR
UMD
UNMZH
UQL
USG
VVN
WH7
WI4
X7M
XJF
XZL
Y6R
YK4
YKV
YNT
YOJ
YR2
YR5
YRY
YSQ
YV5
YWH
YYP
YZZ
ZCA
ZE2
~02
~G0
~KM
~ZZ
7X8
ATCPS
ID FETCH-LOGICAL-c487t-2feb243d536ad7b032e1c61cfb3b785fb45c70abada5a50a2e7a3d9f90bbd9e2
IEDL.DBID 7X8
ISICitedReferencesCount 176
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000677843100040&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1095-9203
IngestDate Sun Nov 09 12:21:01 EST 2025
Mon Jul 21 06:03:46 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6550
Language English
License Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c487t-2feb243d536ad7b032e1c61cfb3b785fb45c70abada5a50a2e7a3d9f90bbd9e2
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-7305-2317
0000-0002-0583-4683
0000-0002-4024-2990
0000-0002-8105-4347
0000-0002-1516-1865
0000-0002-3901-4843
0000-0003-4025-0007
0000-0001-9074-6604
0000-0003-2400-5431
0000-0001-7871-4327
0000-0002-1399-2761
0000-0002-2024-119X
0000-0003-1648-2369
0000-0001-7282-0487
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/9118175
PMID 34210887
PQID 2548408601
PQPubID 23479
ParticipantIDs proquest_miscellaneous_2548408601
pubmed_primary_34210887
PublicationCentury 2000
PublicationDate 2021-07-02
20210702
PublicationDateYYYYMMDD 2021-07-02
PublicationDate_xml – month: 07
  year: 2021
  text: 2021-07-02
  day: 02
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Science (American Association for the Advancement of Science)
PublicationTitleAlternate Science
PublicationYear 2021
References 34750575 - Nat Cell Biol. 2021 Nov;23(11):1108. doi: 10.1038/s41556-021-00778-8
References_xml – reference: 34750575 - Nat Cell Biol. 2021 Nov;23(11):1108. doi: 10.1038/s41556-021-00778-8
SSID ssj0009593
Score 2.6812584
Snippet Spatial patterns of gene expression manifest at scales ranging from local (e.g., cell-cell interactions) to global (e.g., body axis patterning). However,...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 111
SubjectTerms Animals
Atlases as Topic
Body Patterning - genetics
Brain - embryology
Cell Movement
Embryo, Mammalian - embryology
Embryonic Development - genetics
Gene Expression Profiling - methods
Mice
Neurogenesis - genetics
Neurons - cytology
Single-Cell Analysis - methods
Transcriptome
Title Embryo-scale, single-cell spatial transcriptomics
URI https://www.ncbi.nlm.nih.gov/pubmed/34210887
https://www.proquest.com/docview/2548408601
Volume 373
WOSCitedRecordID wos000677843100040&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LSwMxEB7UKnhR67O-WMGDgtHdZNfsnkSkxYOWHor0tuQJgu7WbhX6753spiiCIHjJLSGZzEzmm8wD4DTiMrOao6QlghOnJYmwipHI6NCoCGFznUj79MD7_XQ0ygbe4Vb5sMq5TqwVtS6V85FfIZBBLJIifrgZvxHXNcr9rvoWGovQYmjKuJAuPkp_Ft2NQtePkIbMl_b5ljRzKaR0H5i_25f1O9Nb_-8ON2DNW5jBbcMSbVgwxSasND0nZ5vQ9tJcBWe-5PT5FkTdVzmZlaTCGzMXgfMfvBjinPpB5UKucb2pe9RqFePymKttGPa6w7t74pspEIWYZEqoRQwdM42HFZrLkFETqetIWckkTxMr40TxUEihRSKSUFDDBdOZzUIpdWboDiwVZWH2IJBCWYpXLGI0RXicpCaONUtwJcu00rQDJ3P65Mirbq-iMOV7lX9RqAO7DZHzcVNUI2cxgk_UePt_mH0Aq9SFljgvKz2ElkVJNUewrD6mz9XkuGYCHPuDx0_Se71z
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Embryo-scale%2C+single-cell+spatial+transcriptomics&rft.jtitle=Science+%28American+Association+for+the+Advancement+of+Science%29&rft.au=Srivatsan%2C+Sanjay+R&rft.au=Regier%2C+Mary+C&rft.au=Barkan%2C+Eliza&rft.au=Franks%2C+Jennifer+M&rft.date=2021-07-02&rft.eissn=1095-9203&rft.volume=373&rft.issue=6550&rft.spage=111&rft_id=info:doi/10.1126%2Fscience.abb9536&rft_id=info%3Apmid%2F34210887&rft_id=info%3Apmid%2F34210887&rft.externalDocID=34210887
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1095-9203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1095-9203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1095-9203&client=summon