Replication timing maintains the global epigenetic state in human cells

The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin modifications and three-dimensional genome architecture; however, causal links have not been established, largely because of an inability to manipulate the global RT program. We show that loss of RIF1 causes...

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Vydané v:	Science (American Association for the Advancement of Science) Ročník 372; číslo 6540; s. 371
Hlavní autori:	Klein, Kyle N, Zhao, Peiyao A, Lyu, Xiaowen, Sasaki, Takayo, Bartlett, Daniel A, Singh, Amar M, Tasan, Ipek, Zhang, Meng, Watts, Lotte P, Hiraga, Shin-Ichiro, Natsume, Toyoaki, Zhou, Xuemeng, Baslan, Timour, Leung, Danny, Kanemaki, Masato T, Donaldson, Anne D, Zhao, Huimin, Dalton, Stephen, Corces, Victor G, Gilbert, David M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 23.04.2021
Predmet:	Cell Line Chromatin - metabolism Chromatin Assembly and Disassembly DNA Replication DNA Replication Timing Epigenesis, Genetic Epigenome Gene Expression Gene Knockout Techniques Genome, Human Heterochromatin - metabolism Histone Code Histones - metabolism Humans Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism
ISSN:	1095-9203, 1095-9203
On-line prístup:	Zistit podrobnosti o prístupe
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