Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34βE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung

Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in their morphology, and are discriminated by expression of neuroendocrine markers in LCNEC. Because thyroid transcription factor 1 (TTF-1) is exp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Human pathology Jg. 32; H. 9; S. 918 - 925
Hauptverfasser: Sturm, Nathalie, Lantuéjoul, Sylvie, Laverrière, Marie-Hélène, Papotti, Mauro, Brichon, Pierre-Yves, Brambilla, Christian, Brambilla, Elisabeth
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York, NY Elsevier Inc 01.09.2001
Elsevier
Schlagworte:
34βE12
basaloid carcinoma
Biological and medical sciences
Carcinoma, Large Cell - metabolism
Carcinoma, Large Cell - pathology
Carcinoma, Neuroendocrine - metabolism
Carcinoma, Neuroendocrine - pathology
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Carcinoma, Transitional Cell - metabolism
Carcinoma, Transitional Cell - pathology
Humans
Immunoenzyme Techniques
Keratins - biosynthesis
large-cell neuroendocrine carcinoma
lung neoplasms
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Medical sciences
Nuclear Proteins - biosynthesis
Pneumology
Retrospective Studies
Sensitivity and Specificity
Thyroid Nuclear Factor 1
thyroid transcription factor 1
Transcription Factors - biosynthesis
Tumors of the respiratory system and mediastinum
thyroid transcription factor 1
basaloid carcinoma
BC
SCC
large-cell neuroendocrine carcinoma
lung neoplasms
NCAM
34βE12
NE
LCNEC
TTF-1
WHO
Human
Immunohistochemistry
Lung disease
Cytokeratin
Respiratory disease
Basaloid carcinoma
Malignant tumor
Bronchopulmonary
Differential diagnostic
Pathology
Transcription factor TTF1
Bronchus disease
Large cell carcinoma
Transcription factor
Neuroendocrine tumor
Comparative study
ISSN:0046-8177, 1532-8392
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in their morphology, and are discriminated by expression of neuroendocrine markers in LCNEC. Because thyroid transcription factor 1 (TTF-1) is expressed in lung adenocarcinomas but not in squamous cell carcinomas (SCC), and 34βE12 recognizes a set of high-molecular-weight cytokeratins characteristic of basal stem cells, we hypothesized that these 2 markers could help in distinguishing BC from LCNEC. Immunostaining for TTF-1 was detected in 40.9% of pure LCNEC but in no BC or basaloid variant of SCC. In contrast, immunoreactivity for 34βE12 was shown in all BC and basaloid variant of SCC but in only 1 LCNEC. Bouin fixation was less efficient than formalin in the immunodetection of both markers for its well-known deleterious effect on antigen preservation. Specificity of TTF-1 for LCNEC (100%) and that of 34βE12 for BC (98.3%) exceeded that of NE markers for distinction of these 2 entities. These data show that TTF-1 and 34βE12, in association with specific neuroendocrine markers, represent a useful panel of antibodies in differentiating carcinomas presenting with a solid pattern, palisading, or pseudorosettes, the expression of TTF-1 excluding the diagnosis of BC, and staining with 34βE12 excluding pure LCNEC. HUM PATHOL 32:918-925. Copyright © 2001 by W.B. Saunders Company
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2001.27110