Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

In a follow-up study of patients with type 2 diabetes, mortality benefits in those originally assigned to antihypertensive therapy were evident at the end of follow-up, but in-trial glucose differences did not result in long-term benefits in mortality or macrovascular events. Post-trial follow-up st...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 371; no. 15; pp. 1392 - 1406
Main Authors: Zoungas, Sophia, Chalmers, John, Neal, Bruce, Billot, Laurent, Li, Qiang, Hirakawa, Yoichiro, Arima, Hisatomi, Monaghan, Helen, Joshi, Rohina, Colagiuri, Stephen, Cooper, Mark E, Glasziou, Paul, Grobbee, Diederick, Hamet, Pavel, Harrap, Stephen, Heller, Simon, Lisheng, Liu, Mancia, Giuseppe, Marre, Michel, Matthews, David R, Mogensen, Carl E, Perkovic, Vlado, Poulter, Neil, Rodgers, Anthony, Williams, Bryan, MacMahon, Stephen, Patel, Anushka, Woodward, Mark
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 09.10.2014
Subjects:
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Blood Glucose
Blood pressure
Cardiovascular disease
Confidence intervals
Death
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - mortality
Diabetes. Impaired glucose tolerance
Drug Combinations
Drug dosages
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Follow-Up Studies
General aspects
Gliclazide - administration & dosage
Glucose
Glycated Hemoglobin - analysis
Hemoglobin
Humans
Hypertension - complications
Hypertension - drug therapy
Hypoglycemic Agents - administration & dosage
Indapamide
Indapamide - therapeutic use
Kidney diseases
Male
Medical research
Medical sciences
Middle Aged
Mortality
Perindopril - therapeutic use
Ratios
Risk Factors
Vascular diseases
Australia
Endocrinopathy
Prevention
Type 2 diabetes
Medicine
Check
Metabolic diseases
Arterial pressure
Blood pressure
Glucose
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:In a follow-up study of patients with type 2 diabetes, mortality benefits in those originally assigned to antihypertensive therapy were evident at the end of follow-up, but in-trial glucose differences did not result in long-term benefits in mortality or macrovascular events. Post-trial follow-up studies involving patients with diabetes have previously shown long-term beneficial effects of earlier periods of intensive glucose control, but not blood-pressure lowering, on a range of outcomes, including mortality and macrovascular events. 1 – 3 The Epidemiology of Diabetes Interventions and Complications (EDIC) study, an extension of the Diabetes Control and Complications Trial (DCCT) involving young patients with type 1 diabetes and no history of cardiovascular disease, hypertension, or hypercholesterolemia, showed a lower risk of macrovascular events, as well as a sustained benefit with respect to microvascular complications, beyond the period of intensive glucose control. 1 The post-intervention follow-up of the . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1407963