Breast metastases from oligodendroglioma: An unusual extraneural spread in two young women and a review of the literature

Extraneural dissemination of oligodendroglioma is rare. Cases of breast metastases have never been described in the literature. We report the first two cases of young women with initial diagnosis of anaplastic oligodendroglioma who experienced mammary gland metastases and a review of the literature....

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Veröffentlicht in:Critical reviews in oncology/hematology Jg. 88; H. 3; S. 564 - 572
Hauptverfasser: Mazza, E., Belli, C., Terreni, M., Doglioni, C., Losio, C., Cantore, M., Mambrini, A., Reni, M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ireland Ltd 01.12.2013
Schlagworte:
Adult
Biopsy
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Brain tumors
Breast
Breast Neoplasms - diagnosis
Breast Neoplasms - secondary
Female
Hematology, Oncology and Palliative Medicine
Humans
Magnetic Resonance Angiography
Metastasis
Neoplasm Grading
Neovascularization, Pathologic - diagnosis
Oligodendroglioma
Oligodendroglioma - diagnosis
Oligodendroglioma - pathology
Breast
Metastasis
Brain tumors
Oligodendroglioma
ISSN:1040-8428, 1879-0461, 1879-0461
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Zusammenfassung:Extraneural dissemination of oligodendroglioma is rare. Cases of breast metastases have never been described in the literature. We report the first two cases of young women with initial diagnosis of anaplastic oligodendroglioma who experienced mammary gland metastases and a review of the literature. Immunohistochemical analysis performed on material from both primary and metastatic sites did not allow to draw any conclusion on possible etiopathogenetic hypothesis. A review of literature yielded 35 cases of extracranial metastatic oligodendroglioma from 1989 to 2012. Though rare, extracranial dissemination from oligodendroglioma may occur not only in long surviving heavily pre-treated patients. The review of literature and these two cases suggest that spread is primarily to bone and then from bone to other organs through hematogenous route mostly due to leptomeningeal or dura mater invasion. Chemotherapy regimens similar to those commonly used for non metastatic oligodendroglioma are recommended for patients with good performance status.
Bibliographie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Review-5
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1040-8428
1879-0461
1879-0461
DOI:10.1016/j.critrevonc.2013.07.010