Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B

STUDY QUESTION Does endothelin-1 (ET-1) regulate matrix metalloproteinase (MMP) 14 and 15 production and invasion of human first trimester trophoblasts? SUMMARY ANSWER ET-1 in pathophysiological concentrations down-regulates MMP14 and MMP15 expression via endothelin receptor (ETR) type B and decreas...

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Bibliographic Details
Published in:	Human reproduction (Oxford) Vol. 32; no. 1; pp. 46 - 54
Main Authors:	Majali-Martinez, Alejandro, Velicky, Philipp, Pollheimer, Jürgen, Knöfler, Martin, Yung, Hong wa, Burton, Graham J., Tabrizi-Wizsy, Nassim Ghaffari, Lang, Uwe, Hiden, Ursula, Desoye, Gernot, Dieber-Rotheneder, Martina
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.01.2017
Subjects:	Cell Proliferation - drug effects Dose-Response Relationship, Drug Down-Regulation - drug effects Endothelin-1 - pharmacology Female Humans Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 15 - genetics Matrix Metalloproteinase 15 - metabolism Placenta - drug effects Placenta - metabolism Pregnancy Pregnancy Trimester, First - metabolism Receptor, Endothelin B - genetics Receptor, Endothelin B - metabolism Trophoblasts - drug effects Trophoblasts - metabolism Tumor Necrosis Factor-alpha - pharmacology hypoxia invasion inflammation MMPs pre-eclampsia endothelin-1 trophoblast
ISSN:	0268-1161, 1460-2350
Online Access:	Get full text
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