Dysregulated expression of matrix metalloproteinases and their inhibitors may participate in the pathogenesis of pre-eclampsia and fetal growth restriction

Trophoblast invasion into the maternal endometrium serves an important function in human pregnancy. Dysregulation of the finely controlled process of trophoblast invasion can result in a wide spectrum of pregnancy abnormalities. We aimed to elucidate the relationship between the expression of matrix...

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Veröffentlicht in:Early human development Jg. 90; H. 10; S. 657 - 664
Hauptverfasser: Zhu, JiaYu, Zhong, Mei, Pang, ZhanJun, Yu, YanHong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Ireland Elsevier Ireland Ltd 01.10.2014
Schlagworte:
Advanced Basic Science
Blotting, Western
China
Female
Fetal growth restriction
Fetal Growth Retardation - etiology
Fetal Growth Retardation - physiopathology
Gene Expression Regulation, Enzymologic - physiology
Humans
Immunohistochemistry
Matrix metalloproteinase
Matrix Metalloproteinases - metabolism
Neonatal and Perinatal Medicine
Placenta
Placenta - cytology
Placenta - metabolism
Pre-eclampsia
Pre-Eclampsia - etiology
Pre-Eclampsia - physiopathology
Pregnancy
Statistics, Nonparametric
Tissue inhibitor of metalloproteinase
Tissue Inhibitor of Metalloproteinases - metabolism
Trophoblast invasion
Trophoblast-related diseases
Trophoblasts - metabolism
Trophoblasts - physiology
China
Trophoblast invasion
Placenta
Fetal growth restriction
Tissue inhibitor of metalloproteinase
Trophoblast-related diseases
Matrix metalloproteinase
Pre-eclampsia
ISSN:0378-3782, 1872-6232, 1872-6232
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Zusammenfassung:Trophoblast invasion into the maternal endometrium serves an important function in human pregnancy. Dysregulation of the finely controlled process of trophoblast invasion can result in a wide spectrum of pregnancy abnormalities. We aimed to elucidate the relationship between the expression of matrix metalloproteinases and pregnancy complication. The study group consisted of placental bed biopsy tissues obtained from normal vaginal deliveries (N=15), normal cesarean deliveries (N=15), pre-eclampsia (N=24) and fetal growth restriction (FGR) (N=10). We evaluated the expressions of MMP-2, -8, -9, -11, -19, -15 (MT2-MMP), -16 (MT3-MMP), and -24 (MT5-MMP), as well as TIMP-1 and -3, by applying Western blot and immunohistochemistry methods. Human placental tissues were used for this study. The expressions of MMP-2, -8, -9, -11, -19, -15 (MT2-MMP), -16 (MT3-MMP), and -24 (MT5-MMP), as well as TIMP-1 and -3 in human placenta tissues. Compared with those in normal pregnancies, the expression of MMP-2, -8, -9 and -11 was downregulated in villous tissues of pre-eclampsia and FGR cases (p<0.05). TIMP-1 and -3 were increased in pre-eclampsia and FGR (p<0.05). No significant difference was found between normal vaginal deliveries and cesarean deliveries. We speculate that the change in invasion-associated proteinase expression will affect placental development and may thus contribute to the development of complicated pregnancies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0378-3782
1872-6232
1872-6232
DOI:10.1016/j.earlhumdev.2014.08.007