Nucleic acid polymers: Broad spectrum antiviral activity, antiviral mechanisms and optimization for the treatment of hepatitis B and hepatitis D infection

Antiviral polymers are a well-studied class of broad spectrum viral attachment/entry inhibitors whose activity increases with polymer length and with increased amphipathic (hydrophobic) character. The newest members of this class of compounds are nucleic acid polymers whose activity is derived from...

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Bibliographic Details
Published in:	Antiviral research Vol. 133; pp. 32 - 40
Main Author:	Vaillant, Andrew
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2016
Subjects:	Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral therapy Clinical Trials as Topic HBsAg Hepatitis B - drug therapy Hepatitis B - virology Hepatitis B virus Hepatitis B virus - drug effects Hepatitis D - drug therapy Hepatitis D - virology Hepatitis delta virus Hepatitis Delta Virus - drug effects Humans Nucleic acid polymer Nucleic Acids - chemistry Nucleic Acids - pharmacology Nucleic Acids - therapeutic use Phosphorothioate Oligonucleotides - chemistry Phosphorothioate Oligonucleotides - pharmacology Polymers - chemistry Polymers - pharmacology Polymers - therapeutic use Virus Internalization - drug effects Virus Replication - drug effects HBsAg Antiviral therapy Hepatitis B virus Nucleic acid polymer Hepatitis delta virus
ISSN:	0166-3542, 1872-9096, 1872-9096
Online Access:	Get full text
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