How are Long-Covid, Post-Sepsis-Syndrome and Post-Intensive-Care-Syndrome related? A conceptional approach based on the current research literature

Long-Covid (LC), Post-Sepsis-Syndrome (PSS) and Post-Intensive-Care-Syndrome (PICS) show remarkable overlaps in their clinical presentation. Nevertheless, it is unclear if they are distinct syndromes, which may co-occur in the same patient, or if they are three different labels to describe similar s...

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Published in:Critical care (London, England) Vol. 28; no. 1; p. 283
Main Authors: Fleischmann-Struzek, Carolin, Joost, Franka E. A., Pletz, Mathias W., Weiß, Björn, Paul, Nicolas, Ely, E. Wesley, Reinhart, Konrad, Rose, Norman
Format: Journal Article
Language:English
Published: London BioMed Central 29.08.2024
BioMed Central Ltd
Springer Nature B.V
Subjects:
Bacterial infections
Care and treatment
Chronic illnesses
Cohort analysis
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
Critical Care - methods
Critical Care Medicine
Critical Illness
Delirium
Disease
Emergency Medicine
Health aspects
Humans
Infection
Infections
Intensive
Intensive care
Long COVID
Medicine
Medicine & Public Health
Patients
Post traumatic stress disorder
Post-Acute COVID-19 Syndrome
Review
Sepsis
Sepsis - complications
Severe acute respiratory syndrome coronavirus 2
West Nile virus
United States > US
IACC
Post-Sepsis-Syndrome
PICS
Post-Intensive-Care-Syndrome
Post-covid-syndrome
Long-Covid
ISSN:1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
Online Access:Get full text
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Summary:Long-Covid (LC), Post-Sepsis-Syndrome (PSS) and Post-Intensive-Care-Syndrome (PICS) show remarkable overlaps in their clinical presentation. Nevertheless, it is unclear if they are distinct syndromes, which may co-occur in the same patient, or if they are three different labels to describe similar symptoms, assigned on the basis on patient history and professional perspective of the treating physician. Therefore, we reviewed the current literature on the relation between LC, PSS and PICS. To date, the three syndromes cannot reliably be distinguished due similarities in clinical presentation as they share the cognitive, psychological and physical impairments with only different probabilities of occurrence and a heterogeneity in individual expression. The diagnosis is furthermore hindered by a lack of specific diagnostic tools. It can be concluded that survivors after COVID-19 sepsis likely have more frequent and more severe consequences than patients with milder COVID-19 courses, and that are some COVID-19-specific sequelae, e.g. an increased risk for venous thromboembolism in the 30 days after the acute disease, which occur less often after sepsis of other causes. Patients may profit from leveraging synergies from PICS, PSS and LC treatment as well as from experiences gained from infection-associated chronic conditions in general. Disentangling molecular pathomechanisms may enable future targeted therapies that go beyond symptomatic treatment.
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ISSN:1364-8535
1466-609X
1364-8535
1466-609X
1366-609X
DOI:10.1186/s13054-024-05076-x