Sequential interaction of chloride and proton ions with the fast gate steer the voltage‐dependent gating in ClC‐2 chloride channels

Key points Plasma membrane ClC‐2 chloride channels are widely distributed in our body and are important for vision and fertility. ClC‐2 channels are gated by changes in transmembrane voltage despite of lacking a voltage sensor device. It has been hypothesized that the interaction of an external prot...

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Bibliographic Details
Published in:	The Journal of physiology Vol. 590; no. 17; pp. 4239 - 4253
Main Authors:	Sánchez‐Rodríguez, Jorge E., De Santiago‐Castillo, José A., Contreras‐Vite, Juan Antonio, Nieto‐Delgado, Pablo G., Castro‐Chong, Alejandra, Arreola, Jorge
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.09.2012 Wiley Subscription Services, Inc Blackwell Science Inc
Subjects:	Animals Chloride Channels - chemistry Chloride Channels - genetics Chloride Channels - metabolism Chlorides - metabolism Electrophysiological Phenomena HEK293 Cells Humans Hydrogen-Ion Concentration Ion Channel Gating Ions Kinetics Mice Models, Biological Molecular and Cellular Potassium Protein Conformation Protons Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism
ISSN:	0022-3751, 1469-7793, 1469-7793
Online Access:	Get full text
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