Crucial role of neutrophils in the development of mechanical inflammatory hypernociception

Neutrophil migration is responsible for tissue damage observed in inflammatory diseases. Neutrophils are also implicated in inflammatory nociception, but mechanisms of their participation have not been elucidated. In the present study, we addressed these mechanisms in the carrageenan‐induced mechani...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 83; no. 4; pp. 824 - 832
Main Authors:	Cunha, Thiago M., Verri, Waldiceu A., Schivo, Ieda R., Napimoga, Marcelo H., Parada, Carlos A., Poole, Stephen, Teixeira, Mauro M., Ferreira, Sergio H., Cunha, Fernando Q.
Format:	Journal Article
Language:	English
Published:	United States Society for Leukocyte Biology 01.04.2008
Subjects:	Animals Carrageenan - pharmacology Cell Culture Techniques Chemokine CXCL1 - blood cytokines Cytokines - blood Dinoprostone - metabolism Hindlimb - blood supply hyperalgesia Hyperalgesia - blood Hyperalgesia - physiopathology Inflammation - blood Inflammation - physiopathology Interleukin-1 - blood Male Neutrophils - cytology Neutrophils - drug effects Neutrophils - physiology nociception pain Pain - blood Pain - physiopathology Pain Threshold PGE2 Polysaccharides - pharmacology Rats Rats, Wistar Reaction Time Skin Physiological Phenomena Tumor Necrosis Factor-alpha - blood
ISSN:	0741-5400, 1938-3673
Online Access:	Get full text
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