Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition

[Display omitted] •This is the first long-term (1-year) study to evaluate both the kidney and systemic sequelae of acute kidney injury in mice.•Serial kidney function was measured via transcutaneous glomerular filtration rate.•AKI resulted in diastolic dysfunction, followed by hypertension. Ejection...

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Bibliographic Details
Published in:	JACC. Basic to translational science Vol. 6; no. 2; pp. 119 - 133
Main Authors:	Soranno, Danielle E., Kirkbride-Romeo, Lara, Wennersten, Sara A., Ding, Kathy, Cavasin, Maria A., Baker, Peter, Altmann, Christopher, Bagchi, Rushita A., Haefner, Korey R., Steinkühler, Christian, Montford, John R., Keith, Brysen, Gist, Katja M., McKinsey, Timothy A., Faubel, Sarah
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2021 Elsevier
Subjects:	acute kidney injury cardiorenal syndrome Cardiovascular diastolic dysfunction histone deacetylase inhibition Preclinical Research systemic sequelae of kidney disease SCr histone deacetylase inhibition tGFR PSR cardiorenal syndrome diastolic dysfunction systemic sequelae of kidney disease acute kidney injury BUN ATP HDACi MAP AKI transcutaneous glomerular filtration rate mean arterial pressure blood urea nitrogen serum creatinine picrosirius red histone deacetylase inhibitor adenosine triphosphate SCr, serum creatinine PSR, picrosirius red HDACi, histone deacetylase inhibitor AKI, acute kidney injury MAP, mean arterial pressure tGFR, transcutaneous glomerular filtration rate ATP, adenosine triphosphate BUN, blood urea nitrogen
ISSN:	2452-302X, 2452-302X
Online Access:	Get full text
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