Amide proton transfer (APT) contrast for imaging of brain tumors

In this work we demonstrate that specific MR image contrast can be produced in the water signal that reflects endogenous cellular protein and peptide content in intracranial rat 9L gliosarcomas. Although the concentration of these mobile proteins and peptides is only in the millimolar range, a detec...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Magnetic resonance in medicine Ročník 50; číslo 6; s. 1120 - 1126
Hlavní autori:	Zhou, Jinyuan, Lal, Bachchu, Wilson, David A., Laterra, John, van Zijl, Peter C.M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2003 Williams & Wilkins
Predmet:	9L gliosarcoma amide proton exchange Amides - analysis Animals Biological and medical sciences Brain Neoplasms - chemistry Brain Neoplasms - diagnosis Cell Line, Tumor Diffusion Magnetic Resonance Imaging Gliosarcoma - chemistry Gliosarcoma - diagnosis Magnetic Resonance Imaging - methods magnetization transfer Medical sciences mobile protein Neoplasm Transplantation peptide Protons Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Inbred F344 Sensitivity and Specificity Technology. Biomaterials. Equipments. Material. Instrumentation magnetization transfer peptide 9L gliosarcoma mobile protein amide proton exchange Biomedical engineering
ISSN:	0740-3194, 1522-2594
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	In this work we demonstrate that specific MR image contrast can be produced in the water signal that reflects endogenous cellular protein and peptide content in intracranial rat 9L gliosarcomas. Although the concentration of these mobile proteins and peptides is only in the millimolar range, a detection sensitivity of several percent on the water signal (molar concentration) was achieved. This was accomplished with detection sensitivity enhancement by selective radiofrequency (RF) labeling of the amide protons, and by utilizing the effective transfer of this label to water via hydrogen exchange. Brain tumors were also assessed by conventional T1‐weighted, T2‐weighted, and diffusion‐weighted imaging. Whereas these commonly‐used approaches yielded heterogeneous images, the new amide proton transfer (APT) technique showed a single well‐defined region of hyperintensity that was assigned to brain tumor tissue. Magn Reson Med 50:1120–1126, 2003. © 2003 Wiley‐Liss, Inc.
Bibliografia:	Whitaker Foundation ark:/67375/WNG-Z6Q7SCT2-6 istex:D6FD5FE59B19FF87CEA58B7FDB7F45F66FC97DD1 NIH/NIBIB - No. EB02666 ArticleID:MRM10651 NIH/NINDS - No. NS31490 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0740-3194 1522-2594
DOI:	10.1002/mrm.10651