Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis

Sputum culture reversion after conversion is an indicator of tuberculosis (TB) treatment failure. We analyze data from the endTB multi-country prospective observational cohort (NCT03259269) to estimate the frequency (primary endpoint) among individuals receiving a longer (18-to-20 month) regimen for...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 3927 - 7
Main Authors:	Kho, Sooyeon, Seung, Kwonjune J., Huerga, Helena, Bastard, Mathieu, Khan, Palwasha Y., Mitnick, Carole D., Rich, Michael L., Islam, Shirajul, Zhizhilashvili, Dali, Yeghiazaryan, Lusine, Nikolenko, Elena Nikolaevna, Zarli, Khin, Adnan, Sana, Salahuddin, Naseem, Ahmed, Saman, Vargas, Zully Haydee Ruíz, Bekele, Amsalu, Shaimerdenova, Aiman, Tamirat, Meseret, Gelin, Alain, Vilbrun, Stalz Charles, Hewison, Catherine, Khan, Uzma, Franke, Molly
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.05.2024 Nature Publishing Group Nature Portfolio
Subjects:	692/308/174 692/699/255/1856 Adult Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Body mass index Body size Comorbidity Diarylquinolines - pharmacology Diarylquinolines - therapeutic use Drug Repositioning Drug resistance Drugs Female Hepatitis Hepatitis C Humanities and Social Sciences Humans Male Middle Aged Monitoring multidisciplinary Mycobacterium tuberculosis - drug effects Nitroimidazoles - pharmacology Nitroimidazoles - therapeutic use Oxazoles - therapeutic use Prospective Studies Regression analysis Rifampin Science Science (multidisciplinary) Sputum Sputum - microbiology Telemedicine Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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