Mobile Efficient Diagnostics of Infectious Diseases via On‐Chip RT‐qPCR: MEDIC‐PCR

The COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription polymerase chain reaction (RT‐PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors rep...

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Veröffentlicht in:	Advanced science Jg. 10; H. 28; S. e2302072 - n/a
Hauptverfasser:	Shrestha, Kiran, Kim, Seongryeong, Han, Jiyeon, Florez, Gabriela Morales, Truong, Han, Hoang, Trung, Parajuli, Sajjan, AM, Tiara, Kim, Beomsoo, Jung, Younsu, Abafogi, Abdurhaman Teyib, Lee, Yugyeong, Song, Seung Hyun, Lee, Jinkee, Park, Sungsu, Kang, Minhee, Huh, Hee Jae, Cho, Gyoujin, Lee, Luke P.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Germany John Wiley & Sons, Inc 01.10.2023 John Wiley and Sons Inc Wiley
Schlagworte:	Accuracy Carbon Communicable Diseases - diagnosis COVID-19 COVID-19 - diagnosis COVID-19 Testing diagnostics Efficiency Graphene Humans Infectious diseases Light low‐cost Manufacturing Polyethylene terephthalate Polymerase Chain Reaction rapid Reverse Transcriptase Polymerase Chain Reaction rt‐qpcr Sensitivity and Specificity Severe acute respiratory syndrome coronavirus 2 Thermal energy Thin films rapid covid-19 diagnostics low-cost rt-qpcr
ISSN:	2198-3844, 2198-3844
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Abstract	The COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription polymerase chain reaction (RT‐PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid m obile e fficient d iagnostics of i nfectious diseases via on‐ c hip ‐RT‐quantitative PCR (RT‐qPCR): MEDIC‐PCR. First, the authors use a roll‐to‐roll printing process to accomplish low‐cost carbon‐black‐based disposable PCR chips that enable rapid LED‐induced photothermal PCR cycles. The MEDIC‐PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID‐19 and 103 non‐COVID‐19 patients testing is completed by the MEDIC‐PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC‐PCR can contribute to the preventive global health in the face of a future pandemic.
AbstractList	Abstract The COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription polymerase chain reaction (RT‐PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid mobile efficient diagnostics of infectious diseases via on‐chip ‐RT‐quantitative PCR (RT‐qPCR): MEDIC‐PCR. First, the authors use a roll‐to‐roll printing process to accomplish low‐cost carbon‐black‐based disposable PCR chips that enable rapid LED‐induced photothermal PCR cycles. The MEDIC‐PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID‐19 and 103 non‐COVID‐19 patients testing is completed by the MEDIC‐PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC‐PCR can contribute to the preventive global health in the face of a future pandemic. The COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription polymerase chain reaction (RT‐PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid m obile e fficient d iagnostics of i nfectious diseases via on‐ c hip ‐RT‐quantitative PCR (RT‐qPCR): MEDIC‐PCR. First, the authors use a roll‐to‐roll printing process to accomplish low‐cost carbon‐black‐based disposable PCR chips that enable rapid LED‐induced photothermal PCR cycles. The MEDIC‐PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID‐19 and 103 non‐COVID‐19 patients testing is completed by the MEDIC‐PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC‐PCR can contribute to the preventive global health in the face of a future pandemic. The COVID-19 outbreak has caused public and global health crises. However, the lack of on-site fast, reliable, sensitive, and low-cost reverse transcription polymerase chain reaction (RT-PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid mobile efficient diagnostics of infectious diseases via on-chip -RT-quantitative PCR (RT-qPCR): MEDIC-PCR. First, the authors use a roll-to-roll printing process to accomplish low-cost carbon-black-based disposable PCR chips that enable rapid LED-induced photothermal PCR cycles. The MEDIC-PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID-19 and 103 non-COVID-19 patients testing is completed by the MEDIC-PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC-PCR can contribute to the preventive global health in the face of a future pandemic. The COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription polymerase chain reaction (RT‐PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid mobile efficient diagnostics of infectious diseases via on‐chip ‐RT‐quantitative PCR (RT‐qPCR): MEDIC‐PCR. First, the authors use a roll‐to‐roll printing process to accomplish low‐cost carbon‐black‐based disposable PCR chips that enable rapid LED‐induced photothermal PCR cycles. The MEDIC‐PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID‐19 and 103 non‐COVID‐19 patients testing is completed by the MEDIC‐PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC‐PCR can contribute to the preventive global health in the face of a future pandemic. The highly efficient light‐to‐heat conversion is mediated by multi‐layered graphene and amorphous carbon heterostructure thin film layer via induced electron‐phonon and phonon‐phonon couplings upon irradiation of a NIR light. MEDIC‐PCR achieved ultra‐fast (<15 min) RT‐qPCR with excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. The COVID-19 outbreak has caused public and global health crises. However, the lack of on-site fast, reliable, sensitive, and low-cost reverse transcription polymerase chain reaction (RT-PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid mobile efficient diagnostics of infectious diseases via on-chip -RT-quantitative PCR (RT-qPCR): MEDIC-PCR. First, the authors use a roll-to-roll printing process to accomplish low-cost carbon-black-based disposable PCR chips that enable rapid LED-induced photothermal PCR cycles. The MEDIC-PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID-19 and 103 non-COVID-19 patients testing is completed by the MEDIC-PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC-PCR can contribute to the preventive global health in the face of a future pandemic. The COVID-19 outbreak has caused public and global health crises. However, the lack of on-site fast, reliable, sensitive, and low-cost reverse transcription polymerase chain reaction (RT-PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid mobile efficient diagnostics of infectious diseases via on-chip -RT-quantitative PCR (RT-qPCR): MEDIC-PCR. First, the authors use a roll-to-roll printing process to accomplish low-cost carbon-black-based disposable PCR chips that enable rapid LED-induced photothermal PCR cycles. The MEDIC-PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID-19 and 103 non-COVID-19 patients testing is completed by the MEDIC-PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC-PCR can contribute to the preventive global health in the face of a future pandemic.The COVID-19 outbreak has caused public and global health crises. However, the lack of on-site fast, reliable, sensitive, and low-cost reverse transcription polymerase chain reaction (RT-PCR) testing limits early detection, timely isolation, and epidemic prevention and control. Here, the authors report a rapid mobile efficient diagnostics of infectious diseases via on-chip -RT-quantitative PCR (RT-qPCR): MEDIC-PCR. First, the authors use a roll-to-roll printing process to accomplish low-cost carbon-black-based disposable PCR chips that enable rapid LED-induced photothermal PCR cycles. The MEDIC-PCR can perform RT (3 min), and PCR (9 min) steps. Further, the cohort of 89 COVID-19 and 103 non-COVID-19 patients testing is completed by the MEDIC-PCR to show excellent diagnostic accuracy of 97%, sensitivity of 94%, and specificity of 98%. This MEDIC-PCR can contribute to the preventive global health in the face of a future pandemic.
Author	Park, Sungsu AM, Tiara Abafogi, Abdurhaman Teyib Truong, Han Shrestha, Kiran Kim, Beomsoo Lee, Jinkee Jung, Younsu Kim, Seongryeong Lee, Yugyeong Huh, Hee Jae Cho, Gyoujin Song, Seung Hyun Lee, Luke P. Han, Jiyeon Florez, Gabriela Morales Kang, Minhee Hoang, Trung Parajuli, Sajjan
AuthorAffiliation	5 School of Electronic and Electrical Engineering Sungkyunkwan University Suwon 16419 South Korea 3 Department of Biological Science College of Science Sungkyunkwan University Suwon 16419 South Korea 14 Department of Electrical Engineering and Computer Science University of California at Berkeley Berkeley CA 94720 USA 7 Department of Biomedical Engineering Sungkyunkwan University Suwon 16419 South Korea 8 Department of Electronics Engineering Sookmyung Women's University Seoul 04310 South Korea 12 Harvard Medical School Department of Medicine Brigham Women's Hospital Boston MA 02115 USA 11 School of Medicine Department of Laboratory Medicine and Genetics Samsung Medical Center Sungkyunkwan University Seoul 06351 South Korea 13 Department of Bioengineering University of California at Berkeley Berkeley CA 94720 USA 4 Research Engineering Center for R2R Printed Flexible Computer Sungkyunkwan University Suwon 16419 South Korea 2 Department of Intelligent Precision Healthcare Convergence Sungkyunkwa
AuthorAffiliation_xml	– name: 13 Department of Bioengineering University of California at Berkeley Berkeley CA 94720 USA – name: 2 Department of Intelligent Precision Healthcare Convergence Sungkyunkwan University Suwon 16419 South Korea – name: 3 Department of Biological Science College of Science Sungkyunkwan University Suwon 16419 South Korea – name: 6 School of Mechanical Engineering Sungkyunkwan University Suwon 16419 South Korea – name: 12 Harvard Medical School Department of Medicine Brigham Women's Hospital Boston MA 02115 USA – name: 11 School of Medicine Department of Laboratory Medicine and Genetics Samsung Medical Center Sungkyunkwan University Seoul 06351 South Korea – name: 5 School of Electronic and Electrical Engineering Sungkyunkwan University Suwon 16419 South Korea – name: 4 Research Engineering Center for R2R Printed Flexible Computer Sungkyunkwan University Suwon 16419 South Korea – name: 14 Department of Electrical Engineering and Computer Science University of California at Berkeley Berkeley CA 94720 USA – name: 1 Department of Biophysics Institute of Quantum Biology Sungkyunkwan University Suwon 16419 South Korea – name: 10 Department of Medical Device Management and Research SAIHST (Samsung Advanced Institute for Health Sciences & Technology) Sungkyunkwan University Seoul 06355 South Korea – name: 7 Department of Biomedical Engineering Sungkyunkwan University Suwon 16419 South Korea – name: 8 Department of Electronics Engineering Sookmyung Women's University Seoul 04310 South Korea – name: 9 Biomedical Engineering Research Center Smart Healthcare Research Institute Samsung Medical Center Seoul 06352 South Korea
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and Research SAIHST (Samsung Advanced Institute for Health Sciences & Technology) Sungkyunkwan University Seoul 06355 South Korea – sequence: 17 givenname: Hee Jae surname: Huh fullname: Huh, Hee Jae organization: School of Medicine Department of Laboratory Medicine and Genetics Samsung Medical Center Sungkyunkwan University Seoul 06351 South Korea – sequence: 18 givenname: Gyoujin orcidid: 0000-0002-2451-5426 surname: Cho fullname: Cho, Gyoujin organization: Department of Biophysics Institute of Quantum Biology Sungkyunkwan University Suwon 16419 South Korea, Research Engineering Center for R2R Printed Flexible Computer Sungkyunkwan University Suwon 16419 South Korea – sequence: 19 givenname: Luke P. orcidid: 0000-0002-1436-4054 surname: Lee fullname: Lee, Luke P. organization: Department of Biophysics Institute of Quantum Biology Sungkyunkwan University Suwon 16419 South Korea, Harvard Medical School Department of Medicine Brigham Women's Hospital Boston MA 02115 USA, Department of Bioengineering University of California at Berkeley Berkeley CA 94720 USA, Department of Electrical Engineering and Computer Science University of California at Berkeley Berkeley CA 94720 USA
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Copyright	2023 The Authors. Advanced Science published by Wiley-VCH GmbH. 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH
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Snippet	The COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse transcription... The COVID-19 outbreak has caused public and global health crises. However, the lack of on-site fast, reliable, sensitive, and low-cost reverse transcription... Abstract The COVID‐19 outbreak has caused public and global health crises. However, the lack of on‐site fast, reliable, sensitive, and low‐cost reverse...
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SubjectTerms	Accuracy Carbon Communicable Diseases - diagnosis COVID-19 COVID-19 - diagnosis COVID-19 Testing diagnostics Efficiency Graphene Humans Infectious diseases Light low‐cost Manufacturing Polyethylene terephthalate Polymerase Chain Reaction rapid Reverse Transcriptase Polymerase Chain Reaction rt‐qpcr Sensitivity and Specificity Severe acute respiratory syndrome coronavirus 2 Thermal energy Thin films
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Title	Mobile Efficient Diagnostics of Infectious Diseases via On‐Chip RT‐qPCR: MEDIC‐PCR
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